Peringatan Keamanan

Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.

Doxacurium

DB01135

small molecule approved

Deskripsi

Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration.

Struktur Molekul 2D

Berat 1035.2223
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 99 minutes in normal healthy adults.
Volume Distribusi * 0.11-0.43 L/kg [Healthy Young Adult Patients] * 0.17-0.55 L/kg [Kidney Transplant Patients] * 0.17-0.35 L/kg [Liver Transplant Patients]
Klirens (Clearance) * 2.66 mL/min/kg [Healthy Young Adult Patients] * 1.23 mL/min/kg [Kidney Transplant Patients] * 2.3 mL/min/kg [Liver Transplant Patients] * 1.75 +/- 0.16 mL/min/kg [Elderly patients (70-83 yrs)] * 2.54 +/- 0.24 mL/min/kg [younger patients (19-39 yrs)]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

In vivo data from humans suggest that doxacurium chloride is not metabolized and that the major elimination pathway is excretion of unchanged drug in urine and bile.

Rute Eliminasi

In vivo data from humans suggest that NUROMAX is not metabolized and that the major elimination pathway is excretion of unchanged drug in urine and bile.

Interaksi Obat

1646 Data
Buprenorphine Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Hydrocodone Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Magnesium sulfate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Doxacurium may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Mirtazapine Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Orphenadrine Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Pramipexole Doxacurium may increase the sedative activities of Pramipexole.
Ropinirole Doxacurium may increase the sedative activities of Ropinirole.
Rotigotine Doxacurium may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Doxacurium.
Sodium oxybate The risk or severity of CNS depression can be increased when Doxacurium is combined with Sodium oxybate.
Suvorexant Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxacurium.
Thalidomide Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Capreomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Capreomycin.
Cyclosporine The therapeutic efficacy of Doxacurium can be increased when used in combination with Cyclosporine.
Doxycycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Lymecycline.
Framycetin The therapeutic efficacy of Doxacurium can be increased when used in combination with Framycetin.
Clomocycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Clomocycline.
Quinine The therapeutic efficacy of Doxacurium can be increased when used in combination with Quinine.
Tigecycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Oxytetracycline.
Chloroquine The therapeutic efficacy of Doxacurium can be increased when used in combination with Chloroquine.
Demeclocycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Demeclocycline.
Mecamylamine The therapeutic efficacy of Doxacurium can be increased when used in combination with Mecamylamine.
Tobramycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Tobramycin.
Tetracycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Tetracycline.
Gentamicin The therapeutic efficacy of Doxacurium can be increased when used in combination with Gentamicin.
Etacrynic acid The therapeutic efficacy of Doxacurium can be increased when used in combination with Etacrynic acid.
Metacycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Metacycline.
Netilmicin The therapeutic efficacy of Doxacurium can be increased when used in combination with Netilmicin.
Neomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Neomycin.
Streptomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Streptomycin.
Colistimethate The therapeutic efficacy of Doxacurium can be increased when used in combination with Colistimethate.
Kanamycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Kanamycin.
Rolitetracycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Rolitetracycline.
Magnesium oxide The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium oxide.
Magnesium cation The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium cation.
Paromomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Paromomycin.
Lincomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Lincomycin.
Ribostamycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Ribostamycin.
Geneticin The therapeutic efficacy of Doxacurium can be increased when used in combination with Geneticin.
Apramycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Apramycin.
Gentamicin C1a The therapeutic efficacy of Doxacurium can be increased when used in combination with Gentamicin C1a.
Neamine The therapeutic efficacy of Doxacurium can be increased when used in combination with Neamine.
Arbekacin The therapeutic efficacy of Doxacurium can be increased when used in combination with Arbekacin.
Viomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Viomycin.
Puromycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Puromycin.
Magnesium hydroxide The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium hydroxide.
Magnesium trisilicate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium trisilicate.
Magnesium chloride The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium chloride.
Magnesium acetate tetrahydrate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium acetate tetrahydrate.
Magnesium carbonate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium carbonate.
Magnesium citrate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium citrate.
Magnesium glycinate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium glycinate.
Magnesium Aluminum Silicate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium Aluminum Silicate.
Dihydrostreptomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Dihydrostreptomycin.
Hygromycin B The therapeutic efficacy of Doxacurium can be increased when used in combination with Hygromycin B.
Sisomicin The therapeutic efficacy of Doxacurium can be increased when used in combination with Sisomicin.
Magnesium silicate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium silicate.
Penimepicycline The therapeutic efficacy of Doxacurium can be increased when used in combination with Penimepicycline.
Magnesium aspartate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium aspartate.
Isepamicin The therapeutic efficacy of Doxacurium can be increased when used in combination with Isepamicin.
Magnesium gluconate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium gluconate.
Magnesium orotate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium orotate.
Magnesium phosphate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium phosphate.
Magnesium acetate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium acetate.
Procainamide The therapeutic efficacy of Doxacurium can be increased when used in combination with Procainamide.
Dantrolene The therapeutic efficacy of Doxacurium can be increased when used in combination with Dantrolene.
Piperacillin The therapeutic efficacy of Doxacurium can be increased when used in combination with Piperacillin.
Vancomycin The therapeutic efficacy of Doxacurium can be increased when used in combination with Vancomycin.
Quinidine The therapeutic efficacy of Doxacurium can be increased when used in combination with Quinidine.
Plazomicin The therapeutic efficacy of Doxacurium can be increased when used in combination with Plazomicin.
Magnesium stearate The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium stearate.
Colistin The therapeutic efficacy of Doxacurium can be increased when used in combination with Colistin.
Aclidinium The risk or severity of adverse effects can be increased when Doxacurium is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Doxacurium.
Mirabegron The risk or severity of urinary retention can be increased when Doxacurium is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Doxacurium is combined with Potassium chloride.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Doxacurium.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Doxacurium.
Tiotropium The risk or severity of adverse effects can be increased when Doxacurium is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Doxacurium is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Doxacurium is combined with Umeclidinium.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Doxacurium.
Glycopyrronium The risk or severity of adverse effects can be increased when Doxacurium is combined with Glycopyrronium.
Pegvisomant Pegvisomant may increase the neuromuscular blocking activities of Doxacurium.
Mefloquine Mefloquine may increase the neuromuscular blocking activities of Doxacurium.
Tacrine Tacrine may increase the neuromuscular blocking activities of Doxacurium.

Target Protein

Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Muscarinic acetylcholine receptor M2 CHRM2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9605239
    Martinez EA, Wooldridge AA, Hartsfield SM, Mealey KL: Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs. Vet Surg. 1998 May-Jun;27(3):279-83.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Nuromax
    Injection • 1 mg/1mL • Intravenous • US • Approved
  • Nuromax
    Liquid • 1 mg / mL • Intravenous • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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