Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
Patients with this genotype have reduced metabolism of proguanil.
Patients with this genotype have reduced metabolism of proguanil.
| Dabrafenib | The serum concentration of Proguanil can be decreased when it is combined with Dabrafenib. |
| Artemether | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Artemether. |
| Lumefantrine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Lumefantrine. |
| Luliconazole | The serum concentration of Proguanil can be increased when it is combined with Luliconazole. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Proguanil. |
| Ritonavir | The serum concentration of Proguanil can be decreased when it is combined with Ritonavir. |
| Efavirenz | The serum concentration of Cycloguanil, an active metabolite of Proguanil, can be decreased when used in combination with Efavirenz. |
| Tetrahydrofolic acid | The therapeutic efficacy of Proguanil can be decreased when used in combination with Tetrahydrofolic acid. |
| Folic acid | The therapeutic efficacy of Proguanil can be decreased when used in combination with Folic acid. |
| Leucovorin | The therapeutic efficacy of Proguanil can be decreased when used in combination with Leucovorin. |
| (6S)-5,6,7,8-tetrahydrofolic acid | The therapeutic efficacy of Proguanil can be decreased when used in combination with (6S)-5,6,7,8-tetrahydrofolic acid. |
| Triglu-5-formyl-tetrahydrofolate | The therapeutic efficacy of Proguanil can be decreased when used in combination with Triglu-5-formyl-tetrahydrofolate. |
| Levoleucovorin | The therapeutic efficacy of Proguanil can be decreased when used in combination with Levoleucovorin. |
| 5-methyltetrahydrofolic acid | The therapeutic efficacy of Proguanil can be decreased when used in combination with 5-methyltetrahydrofolic acid. |
| Warfarin | Proguanil may increase the anticoagulant activities of Warfarin. |
| Acenocoumarol | Proguanil may increase the anticoagulant activities of Acenocoumarol. |
| (R)-warfarin | Proguanil may increase the anticoagulant activities of (R)-warfarin. |
| R,S-Warfarin alcohol | Proguanil may increase the anticoagulant activities of R,S-Warfarin alcohol. |
| S,R-Warfarin alcohol | Proguanil may increase the anticoagulant activities of S,R-Warfarin alcohol. |
| (S)-Warfarin | Proguanil may increase the anticoagulant activities of (S)-Warfarin. |
| Thiethylperazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Thiethylperazine. |
| Promazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Promazine. |
| Prochlorperazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Prochlorperazine. |
| Chlorpromazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Chlorpromazine. |
| Triflupromazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Triflupromazine. |
| Fluphenazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Fluphenazine. |
| Thioridazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Thioridazine. |
| Moricizine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Moricizine. |
| Trifluoperazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Trifluoperazine. |
| Perphenazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Perphenazine. |
| Mesoridazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Mesoridazine. |
| Acetophenazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Acetophenazine. |
| Promethazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Promethazine. |
| Alimemazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Alimemazine. |
| Methotrimeprazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Methotrimeprazine. |
| Periciazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Periciazine. |
| Acepromazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Acepromazine. |
| Aceprometazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Aceprometazine. |
| Pipotiazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Pipotiazine. |
| Thioproperazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Thioproperazine. |
| BL-1020 | The risk or severity of QTc prolongation can be increased when Proguanil is combined with BL-1020. |
| Cyamemazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Cyamemazine. |
| Methylene blue | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Methylene blue. |
| Propiopromazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Propiopromazine. |
| Perazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Perazine. |
| Butaperazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Butaperazine. |
| Chlorproethazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Chlorproethazine. |
| Thiazinam | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Thiazinam. |
| Dixyrazine | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Dixyrazine. |
| Perphenazine enanthate | The risk or severity of QTc prolongation can be increased when Proguanil is combined with Perphenazine enanthate. |
| Dapsone | The risk or severity of adverse effects can be increased when Proguanil is combined with Dapsone. |
| Lumacaftor | The serum concentration of Proguanil can be decreased when it is combined with Lumacaftor. |
| Fluvoxamine | The metabolism of Proguanil can be decreased when combined with Fluvoxamine. |
| Ticlopidine | The metabolism of Proguanil can be decreased when combined with Ticlopidine. |
| Chloramphenicol | The metabolism of Proguanil can be decreased when combined with Chloramphenicol. |
| Lansoprazole | The metabolism of Proguanil can be decreased when combined with Lansoprazole. |
| Fluoxetine | The metabolism of Proguanil can be decreased when combined with Fluoxetine. |
| Zafirlukast | The metabolism of Proguanil can be decreased when combined with Zafirlukast. |
| Isoniazid | The metabolism of Proguanil can be decreased when combined with Isoniazid. |
| Stiripentol | The metabolism of Proguanil can be decreased when combined with Stiripentol. |
| Eslicarbazepine acetate | The metabolism of Proguanil can be decreased when combined with Eslicarbazepine acetate. |
| Troglitazone | The metabolism of Proguanil can be decreased when combined with Troglitazone. |
| Nabilone | The metabolism of Proguanil can be decreased when combined with Nabilone. |
| Imatinib | The metabolism of Proguanil can be decreased when combined with Imatinib. |
| Mifepristone | The metabolism of Proguanil can be decreased when combined with Mifepristone. |
| Felbamate | The metabolism of Proguanil can be decreased when combined with Felbamate. |
| Sulfinpyrazone | The metabolism of Proguanil can be decreased when combined with Sulfinpyrazone. |
| Iproniazid | The metabolism of Proguanil can be decreased when combined with Iproniazid. |
| Medical Cannabis | The metabolism of Proguanil can be decreased when combined with Medical Cannabis. |
| Amiodarone | The metabolism of Proguanil can be decreased when combined with Amiodarone. |
| Valproic acid | The metabolism of Proguanil can be decreased when combined with Valproic acid. |
| Quinidine | The metabolism of Proguanil can be decreased when combined with Quinidine. |
| Fluconazole | The metabolism of Proguanil can be decreased when combined with Fluconazole. |
| Floxuridine | The metabolism of Proguanil can be decreased when combined with Floxuridine. |
| Nicardipine | The metabolism of Proguanil can be decreased when combined with Nicardipine. |
| Delavirdine | The metabolism of Proguanil can be decreased when combined with Delavirdine. |
| Miconazole | The metabolism of Proguanil can be decreased when combined with Miconazole. |
| Gemfibrozil | The metabolism of Proguanil can be decreased when combined with Gemfibrozil. |
| Sulfaphenazole | The metabolism of Proguanil can be decreased when combined with Sulfaphenazole. |
| Typhoid Vaccine Live | The therapeutic efficacy of Typhoid Vaccine Live can be decreased when used in combination with Proguanil. |
| Vemurafenib | The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Proguanil. |
| Apalutamide | The serum concentration of Proguanil can be increased when it is combined with Apalutamide. |
| Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Proguanil. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be decreased when combined with Proguanil. |
| Bortezomib | The metabolism of Proguanil can be decreased when combined with Bortezomib. |
| Pantoprazole | The metabolism of Proguanil can be decreased when combined with Pantoprazole. |
| Citalopram | The metabolism of Proguanil can be decreased when combined with Citalopram. |
| Olanzapine | The metabolism of Proguanil can be decreased when combined with Olanzapine. |
| Omeprazole | The metabolism of Proguanil can be decreased when combined with Omeprazole. |
| Clozapine | The serum concentration of Clozapine can be increased when it is combined with Proguanil. |
| Nilutamide | The metabolism of Proguanil can be decreased when combined with Nilutamide. |
| Esomeprazole | The metabolism of Proguanil can be decreased when combined with Esomeprazole. |
| Ethanol | The metabolism of Proguanil can be decreased when combined with Ethanol. |
| Zonisamide | The metabolism of Proguanil can be decreased when combined with Zonisamide. |
| Memantine | The metabolism of Proguanil can be decreased when combined with Memantine. |
| Etoricoxib | The metabolism of Proguanil can be decreased when combined with Etoricoxib. |
| Oritavancin | The metabolism of Proguanil can be decreased when combined with Oritavancin. |
| Dexlansoprazole | The metabolism of Dexlansoprazole can be decreased when combined with Proguanil. |
| Dovitinib | The metabolism of Proguanil can be decreased when combined with Dovitinib. |
| Sitaxentan | The metabolism of Proguanil can be decreased when combined with Sitaxentan. |