Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Trastuzumab | The risk or severity of neutropenia can be increased when Trastuzumab is combined with Prednicarbate. |
| Tacrolimus | Tacrolimus may increase the immunosuppressive activities of Prednicarbate. |
| Segesterone acetate | The metabolism of Segesterone acetate can be increased when combined with Prednicarbate. |
| Cholestyramine | Cholestyramine may increase the excretion rate of Prednicarbate which could result in a lower serum level and potentially a reduction in efficacy. |
| Phenylephrine | The risk or severity of hypertension can be increased when Prednicarbate is combined with Phenylephrine. |
| Aminoglutethimide | The therapeutic efficacy of Prednicarbate can be decreased when used in combination with Aminoglutethimide. |
| Insulin human | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin human. |
| Insulin lispro | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin lispro. |
| Insulin glargine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin glargine. |
| Insulin pork | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin pork. |
| Troglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Troglitazone. |
| Glimepiride | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Glimepiride. |
| Sulfisoxazole | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Sulfisoxazole. |
| Disopyramide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Disopyramide. |
| Acarbose | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Acarbose. |
| Metformin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Metformin. |
| Sulfadiazine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Sulfadiazine. |
| Rosiglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Rosiglitazone. |
| Acetohexamide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Acetohexamide. |
| Quinine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Quinine. |
| Miglitol | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Miglitol. |
| Chlorpropamide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Chlorpropamide. |
| Nateglinide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Nateglinide. |
| Pentamidine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Pentamidine. |
| Tolazamide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Tolazamide. |
| Repaglinide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Repaglinide. |
| Phenformin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Phenformin. |
| Glyburide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Glyburide. |
| Glipizide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Glipizide. |
| Gliclazide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Gliclazide. |
| Tolbutamide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Tolbutamide. |
| Pioglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Pioglitazone. |
| Bromocriptine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Bromocriptine. |
| Gliquidone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Gliquidone. |
| Mitiglinide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Mitiglinide. |
| Sitagliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Sitagliptin. |
| Sunitinib | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Sunitinib. |
| Exenatide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Exenatide. |
| Mecasermin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Mecasermin. |
| Pramlintide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Pramlintide. |
| Glisoxepide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Glisoxepide. |
| Insulin aspart | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin aspart. |
| Insulin detemir | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin detemir. |
| Insulin glulisine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin glulisine. |
| Glymidine | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Glymidine. |
| AICA ribonucleotide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with AICA ribonucleotide. |
| Buformin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Buformin. |
| Vildagliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Vildagliptin. |
| Voglibose | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Voglibose. |
| NN344 | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with NN344. |
| AMG-222 | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with AMG-222. |
| Bisegliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Bisegliptin. |
| Alogliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Alogliptin. |
| Dapagliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Dapagliflozin. |
| Saxagliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Saxagliptin. |
| Liraglutide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Liraglutide. |
| Gosogliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Gosogliptin. |
| Linagliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Linagliptin. |
| Canagliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Canagliflozin. |
| Glibornuride | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Glibornuride. |
| Benfluorex | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Benfluorex. |
| Empagliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Empagliflozin. |
| Albiglutide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Albiglutide. |
| Dulaglutide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Dulaglutide. |
| Lobeglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Lobeglitazone. |
| Netoglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Netoglitazone. |
| Rivoglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Rivoglitazone. |
| Ciglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Ciglitazone. |
| Lixisenatide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Lixisenatide. |
| Insulin beef | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin beef. |
| Insulin degludec | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin degludec. |
| Insulin peglispro | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin peglispro. |
| Insulin tregopil | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Insulin tregopil. |
| Ipragliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Ipragliflozin. |
| Dutogliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Dutogliptin. |
| Allicin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Allicin. |
| Tofogliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Tofogliflozin. |
| Ertugliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Ertugliflozin. |
| 2,4-thiazolidinedione | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with 2,4-thiazolidinedione. |
| Teneligliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Teneligliptin. |
| Omarigliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Omarigliptin. |
| Carmegliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Carmegliptin. |
| Gemigliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Gemigliptin. |
| Anagliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Anagliptin. |
| Evogliptin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Evogliptin. |
| Sotagliflozin | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Sotagliflozin. |
| Balaglitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Balaglitazone. |
| Remogliflozin etabonate | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Remogliflozin etabonate. |
| Carbutamide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Carbutamide. |
| Guar gum | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Guar gum. |
| Metahexamide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Metahexamide. |
| Semaglutide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Semaglutide. |
| Taspoglutide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Taspoglutide. |
| Englitazone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Englitazone. |
| Tirzepatide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Tirzepatide. |
| Gastric inhibitory polypeptide | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Gastric inhibitory polypeptide. |
| Mifepristone | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Mifepristone. |
| Sulfamethoxazole | The risk or severity of hyperglycemia can be increased when Prednicarbate is combined with Sulfamethoxazole. |
| Isoniazid | The serum concentration of Isoniazid can be decreased when it is combined with Prednicarbate. |
| Cyclosporine | The risk or severity of adverse effects can be increased when Prednicarbate is combined with Cyclosporine. |