Bicalutamide

DB01128

small molecule approved

Deskripsi

Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.

Struktur Molekul 2D

Berat 430.373
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 5.9 days
Volume Distribusi -
Klirens (Clearance) * Apparent oral cl=0.32 L/h [Normal Males]

Absorpsi

Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.

Metabolisme

Bicalutamide undergoes stereo specific metabolism. The S (inactive) isomer is metabolized primarily by glucuronidation. The R (active) isomer also undergoes glucuronidation but is predominantly oxidized to an inactive metabolite followed by glucuronidation.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Take at the same time every day.
  • 2. Take with or without food. Food does not significantly affect absorption.

Interaksi Obat

564 Data
Modafinil The metabolism of Bicalutamide can be increased when combined with Modafinil.
Armodafinil The metabolism of Bicalutamide can be increased when combined with Armodafinil.
Lomitapide The metabolism of Lomitapide can be decreased when combined with Bicalutamide.
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Bicalutamide.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Bicalutamide.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Bicalutamide.
Colchicine The metabolism of Colchicine can be decreased when combined with Bicalutamide.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Bicalutamide.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Bicalutamide.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Bicalutamide.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Bicalutamide.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Bicalutamide.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Bicalutamide.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Bicalutamide.
Metreleptin The metabolism of Bicalutamide can be increased when combined with Metreleptin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Bicalutamide.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Bicalutamide.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Bicalutamide.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Bicalutamide.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Bicalutamide.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Bicalutamide.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Bicalutamide.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Bicalutamide.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Bicalutamide.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Bicalutamide.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Bicalutamide.
Crizotinib The metabolism of Bicalutamide can be decreased when combined with Crizotinib.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Bicalutamide.
Astemizole The serum concentration of Astemizole can be increased when it is combined with Bicalutamide.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Bicalutamide.
Choline C 11 Bicalutamide may decrease effectiveness of Choline C 11 as a diagnostic agent.
Capromab pendetide Bicalutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Pitolisant The serum concentration of Bicalutamide can be decreased when it is combined with Pitolisant.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Bicalutamide.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Bicalutamide.
Etravirine The metabolism of Bicalutamide can be increased when combined with Etravirine.
Bexarotene The metabolism of Bicalutamide can be increased when combined with Bexarotene.
Bosentan The metabolism of Bicalutamide can be increased when combined with Bosentan.
Nafcillin The metabolism of Bicalutamide can be increased when combined with Nafcillin.
Avasimibe The metabolism of Bicalutamide can be increased when combined with Avasimibe.
Echinacea The metabolism of Bicalutamide can be increased when combined with Echinacea.
Dexamethasone acetate The metabolism of Bicalutamide can be increased when combined with Dexamethasone acetate.
Lesinurad The metabolism of Bicalutamide can be increased when combined with Lesinurad.
Rufinamide The metabolism of Bicalutamide can be increased when combined with Rufinamide.
Asunaprevir The metabolism of Bicalutamide can be increased when combined with Asunaprevir.
Esketamine The metabolism of Bicalutamide can be increased when combined with Esketamine.
Topiramate The metabolism of Bicalutamide can be increased when combined with Topiramate.
Rifabutin The metabolism of Bicalutamide can be increased when combined with Rifabutin.
Felbamate The metabolism of Bicalutamide can be increased when combined with Felbamate.
Genistein The metabolism of Bicalutamide can be increased when combined with Genistein.
Oritavancin The metabolism of Bicalutamide can be increased when combined with Oritavancin.
Glycerol phenylbutyrate The metabolism of Bicalutamide can be increased when combined with Glycerol phenylbutyrate.
Eslicarbazepine acetate The metabolism of Bicalutamide can be increased when combined with Eslicarbazepine acetate.
Sarilumab The metabolism of Bicalutamide can be increased when combined with Sarilumab.
Isavuconazole The metabolism of Bicalutamide can be increased when combined with Isavuconazole.
Cyclophosphamide The metabolism of Bicalutamide can be increased when combined with Cyclophosphamide.
Methylphenobarbital The metabolism of Bicalutamide can be increased when combined with Methylphenobarbital.
Barbital The metabolism of Bicalutamide can be increased when combined with Barbital.
Seratrodast The metabolism of Bicalutamide can be increased when combined with Seratrodast.
Troglitazone The metabolism of Bicalutamide can be increased when combined with Troglitazone.
Rofecoxib The metabolism of Bicalutamide can be increased when combined with Rofecoxib.
Testosterone The metabolism of Bicalutamide can be increased when combined with Testosterone.
Phenylbutazone The metabolism of Bicalutamide can be increased when combined with Phenylbutazone.
Terbinafine The metabolism of Bicalutamide can be increased when combined with Terbinafine.
Thiamylal The metabolism of Bicalutamide can be increased when combined with Thiamylal.
Tesmilifene The metabolism of Bicalutamide can be increased when combined with Tesmilifene.
Clevidipine The metabolism of Bicalutamide can be increased when combined with Clevidipine.
Chlorpromazine The metabolism of Bicalutamide can be increased when combined with Chlorpromazine.
Fosaprepitant The metabolism of Bicalutamide can be increased when combined with Fosaprepitant.
Quinine The metabolism of Bicalutamide can be increased when combined with Quinine.
Estradiol acetate The metabolism of Bicalutamide can be increased when combined with Estradiol acetate.
Estradiol benzoate The metabolism of Bicalutamide can be increased when combined with Estradiol benzoate.
Estradiol cypionate The metabolism of Bicalutamide can be increased when combined with Estradiol cypionate.
Estradiol dienanthate The metabolism of Bicalutamide can be increased when combined with Estradiol dienanthate.
Estradiol valerate The metabolism of Bicalutamide can be increased when combined with Estradiol valerate.
Acetaminophen The metabolism of Bicalutamide can be increased when combined with Acetaminophen.
Clobazam The metabolism of Bicalutamide can be increased when combined with Clobazam.
Calcitriol The metabolism of Bicalutamide can be increased when combined with Calcitriol.
Vitamin E The metabolism of Bicalutamide can be increased when combined with Vitamin E.
Flunisolide The metabolism of Bicalutamide can be increased when combined with Flunisolide.
Butalbital The metabolism of Bicalutamide can be increased when combined with Butalbital.
Flucloxacillin The metabolism of Bicalutamide can be increased when combined with Flucloxacillin.
Aminoglutethimide The metabolism of Bicalutamide can be increased when combined with Aminoglutethimide.
Beclomethasone dipropionate The metabolism of Bicalutamide can be increased when combined with Beclomethasone dipropionate.
Griseofulvin The metabolism of Bicalutamide can be increased when combined with Griseofulvin.
Secobarbital The metabolism of Bicalutamide can be increased when combined with Secobarbital.
Cerivastatin The metabolism of Bicalutamide can be increased when combined with Cerivastatin.
Betamethasone The metabolism of Bicalutamide can be increased when combined with Betamethasone.
Dicloxacillin The metabolism of Bicalutamide can be increased when combined with Dicloxacillin.
Fluocinolone acetonide The metabolism of Bicalutamide can be increased when combined with Fluocinolone acetonide.
Medroxyprogesterone acetate The metabolism of Bicalutamide can be increased when combined with Medroxyprogesterone acetate.
Triamcinolone The metabolism of Bicalutamide can be increased when combined with Triamcinolone.
Clofibrate The metabolism of Bicalutamide can be increased when combined with Clofibrate.
Hydrocortisone The metabolism of Bicalutamide can be increased when combined with Hydrocortisone.
Mometasone The metabolism of Bicalutamide can be increased when combined with Mometasone.
Hydrocortamate The metabolism of Bicalutamide can be increased when combined with Hydrocortamate.
Oxcarbazepine The metabolism of Bicalutamide can be increased when combined with Oxcarbazepine.
Mifepristone The metabolism of Bicalutamide can be increased when combined with Mifepristone.
Prednisolone The metabolism of Bicalutamide can be increased when combined with Prednisolone.
Ethanol The metabolism of Bicalutamide can be increased when combined with Ethanol.

Target Protein

Androgen receptor AR

Referensi & Sumber

Synthesis reference: Nnochiri Ekwuribe, "METHODS OF SYNTHESIZING ACYLANILIDES INCLUDING BICALUTAMIDE AND DERIVATIVES THEREOF." U.S. Patent US20020165406, issued November 07, 2002.

Contoh Produk & Brand

Produk: 62 • International brands: 0
Produk
  • Accel-bicalutamide Tablets USP
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Ach-bicalutamide
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Act Bicalutamide
    Tablet • 50 mg • Oral • Canada • Approved
  • Ag-bicalutamide
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Apo-bicalutamide
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Ava-bicalutamide
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Bicalutamide
    Tablet, film coated • 50 mg/1 • Oral • US • Generic • Approved
  • Bicalutamide
    Tablet, film coated • 50 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 62 produk.

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