Peringatan Keamanan

Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.

Econazole

DB01127

small molecule approved

Deskripsi

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.

Struktur Molekul 2D

Berat 381.684
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

106 Data
Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Econazole.
Levamlodipine The serum concentration of Levamlodipine can be increased when it is combined with Econazole.
Tramadol The metabolism of Tramadol can be decreased when combined with Econazole.
Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Econazole.
Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Econazole.
Entrectinib The metabolism of Entrectinib can be decreased when combined with Econazole.
Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Econazole.
Colchicine The serum concentration of Colchicine can be increased when it is combined with Econazole.
Dronedarone The metabolism of Dronedarone can be decreased when combined with Econazole.
Elexacaftor The serum concentration of Elexacaftor can be increased when it is combined with Econazole.
Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Econazole.
Enfortumab vedotin The serum concentration of Enfortumab vedotin can be increased when it is combined with Econazole.
Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Econazole.
Upadacitinib The metabolism of Upadacitinib can be decreased when combined with Econazole.
Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Econazole.
Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Econazole.
Ranolazine The metabolism of Ranolazine can be decreased when combined with Econazole.
Rimegepant The metabolism of Rimegepant can be decreased when combined with Econazole.
Osilodrostat The serum concentration of Osilodrostat can be increased when it is combined with Econazole.
Neratinib The serum concentration of Neratinib can be increased when it is combined with Econazole.
Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Econazole.
Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Econazole.
Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Econazole.
Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Econazole.
Bortezomib The metabolism of Bortezomib can be decreased when combined with Econazole.
Lurbinectedin The serum concentration of Lurbinectedin can be increased when it is combined with Econazole.
Oliceridine The serum concentration of Oliceridine can be increased when it is combined with Econazole.
Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Econazole.
Voclosporin The metabolism of Voclosporin can be decreased when combined with Econazole.
Tepotinib The serum concentration of Tepotinib can be increased when it is combined with Econazole.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Econazole.
Avanafil The metabolism of Avanafil can be decreased when combined with Econazole.
Silodosin The metabolism of Silodosin can be decreased when combined with Econazole.
Pimavanserin The metabolism of Pimavanserin can be decreased when combined with Econazole.
Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Econazole.
Infigratinib The metabolism of Infigratinib can be decreased when combined with Econazole.
Ibrexafungerp The serum concentration of Ibrexafungerp can be increased when it is combined with Econazole.
Finerenone The serum concentration of the active metabolites of Finerenone can be increased when Finerenone is used in combination with Econazole.
Methysergide The serum concentration of Methysergide can be increased when it is combined with Econazole.
Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Econazole.
Dihydroergotamine The serum concentration of Dihydroergotamine can be increased when it is combined with Econazole.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Econazole.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Econazole.
Ergotamine The serum concentration of Ergotamine can be increased when it is combined with Econazole.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Econazole.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Econazole.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Econazole.
Bromocriptine The serum concentration of Bromocriptine can be increased when it is combined with Econazole.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Econazole.
Lysergic acid diethylamide The serum concentration of Lysergic acid diethylamide can be increased when it is combined with Econazole.
Dihydroergocornine The serum concentration of Dihydroergocornine can be increased when it is combined with Econazole.
Dihydroergocristine The serum concentration of Dihydroergocristine can be increased when it is combined with Econazole.
Dihydroergocryptine The serum concentration of Dihydroergocryptine can be increased when it is combined with Econazole.
Terguride The serum concentration of Terguride can be increased when it is combined with Econazole.
Metergoline The serum concentration of Metergoline can be increased when it is combined with Econazole.
Simvastatin The risk or severity of myopathy and rhabdomyolysis can be increased when Econazole is combined with Simvastatin.
Mobocertinib The serum concentration of Mobocertinib can be increased when it is combined with Econazole.
Tisotumab vedotin The metabolism of Tisotumab vedotin can be decreased when combined with Econazole.
Atogepant The serum concentration of Atogepant can be increased when it is combined with Econazole.
Asciminib The serum concentration of Asciminib can be increased when it is combined with Econazole.
Daridorexant The metabolism of Daridorexant can be decreased when combined with Econazole.
Palovarotene The serum concentration of Palovarotene can be increased when it is combined with Econazole.
Mitapivat The metabolism of Mitapivat can be decreased when combined with Econazole.
Pacritinib The serum concentration of Pacritinib can be increased when it is combined with Econazole.
Cariprazine The metabolism of Cariprazine can be decreased when combined with Econazole.
Mavacamten The serum concentration of Mavacamten can be increased when it is combined with Econazole.
Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Econazole.
Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Econazole.
Imatinib The serum concentration of Imatinib can be increased when it is combined with Econazole.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Econazole.
Loperamide The metabolism of Loperamide can be decreased when combined with Econazole.
Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Econazole.
Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Econazole.
Futibatinib The metabolism of Futibatinib can be decreased when combined with Econazole.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Econazole.
Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Econazole.
Mirvetuximab soravtansine The serum concentration of Mirvetuximab Soravtansine can be increased when it is combined with Econazole.
Polatuzumab vedotin The serum concentration of monomethyl auristatin E (MMAE), an active metabolite of Polatuzumab vedotin, can be increased when used in combination with Econazole.
Adagrasib The serum concentration of Adagrasib can be increased when it is combined with Econazole.
Clozapine The serum concentration of Clozapine can be increased when it is combined with Econazole.
Pirtobrutinib The serum concentration of Pirtobrutinib can be increased when it is combined with Econazole.
Elacestrant The serum concentration of Elacestrant can be increased when it is combined with Econazole.
Sparsentan The serum concentration of Sparsentan can be increased when it is combined with Econazole.
Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Econazole.
Omaveloxolone The serum concentration of Omaveloxolone can be increased when it is combined with Econazole.
Tretinoin The metabolism of Tretinoin can be decreased when combined with Econazole.
Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Econazole.
Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Econazole.
Vilanterol The serum concentration of Vilanterol can be increased when it is combined with Econazole.
Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Econazole.
Quizartinib The serum concentration of Quizartinib can be increased when it is combined with Econazole.
Zuranolone The serum concentration of Zuranolone can be increased when it is combined with Econazole.
Valbenazine The serum concentration of Valbenazine can be increased when it is combined with Econazole.
Gepirone The serum concentration of Gepirone can be increased when it is combined with Econazole.
Copanlisib The metabolism of Copanlisib can be decreased when combined with Econazole.
Etrasimod The serum concentration of Etrasimod can be increased when it is combined with Econazole.
Encorafenib The serum concentration of Encorafenib can be increased when it is combined with Econazole.
Vamorolone The serum concentration of Vamorolone can be increased when it is combined with Econazole.
Capivasertib The serum concentration of Capivasertib can be increased when it is combined with Econazole.
Repotrectinib The serum concentration of Repotrectinib can be increased when it is combined with Econazole.

Target Protein

Lanosterol 14-alpha demethylase ERG11
Nuclear receptor subfamily 1 group I member 2 NR1I2

Referensi & Sumber

Synthesis reference: Godefroi, E.F. and Heeres, J.; U.S. Patent 3,717,655; February 20,1973; assigned to Jansen Pharmaceutica NV, Belgium.

Contoh Produk & Brand

Produk: 44 • International brands: 5
Produk
  • 071023 Econazole Nitrate 1% / Niacinamide 4%
    Cream • - • Topical • US
  • Econasil
    Kit • 10 mg/1g • Topical • US
  • Econavix
    Kit • - • Topical • US • Generic • Approved
  • Econavix
    Kit • - • Topical • US • Generic • Approved
  • Econavix
    Kit • - • Topical • US • Generic • Approved
  • Econazole Nitrate
    Cream • 10 mg/1g • Topical • US • Generic • Approved
  • Econazole Nitrate
    Cream • 10 mg/1g • Topical • US • Generic • Approved
  • Econazole Nitrate
    Cream • 10 mg/1g • Topical • US • Generic • Approved
Menampilkan 8 dari 44 produk.
International Brands
  • Ecostatin — Bristol-Myers Squibb
  • Gyno-Pevaryl — Janssen
  • Ifenec — Italfarmaco
  • Palavale — Otsuka Pharmaceutical
  • Pevaryl — Janssen

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul