Peringatan Keamanan

LD50=150±44 mg/kg (orally in mice). Symptoms of overdose include muscle twitching, weakness and paralysis of voluntary muscles including the tongue, shoulders, neck and arms, blood pressure increase (with or without a slowing of heart rate), a sensation of internal trembling, severe anxiety, and panic. Death may occur rapidly if untreated.

Ambenonium

DB01122

small molecule approved

Deskripsi

Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.

Struktur Molekul 2D

Berat 537.565
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Oral - poorly absorbed from the gastrointestinal tract.

Metabolisme

Plasma and hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

292 Data
Dipyridamole The therapeutic efficacy of Ambenonium can be decreased when used in combination with Dipyridamole.
Ephedrine Ambenonium may increase the neuromuscular blocking activities of Ephedrine.
Bambuterol Ambenonium may increase the neuromuscular blocking activities of Bambuterol.
Clevidipine Ambenonium may increase the neuromuscular blocking activities of Clevidipine.
Sar9, Met (O2)11-Substance P Ambenonium may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.
Mirabegron Ambenonium may increase the neuromuscular blocking activities of Mirabegron.
Moxisylyte Ambenonium may increase the neuromuscular blocking activities of Moxisylyte.
Propacetamol Ambenonium may increase the neuromuscular blocking activities of Propacetamol.
Procaine Ambenonium may increase the neuromuscular blocking activities of Procaine.
Cocaine Ambenonium may increase the neuromuscular blocking activities of Cocaine.
Trimethaphan Ambenonium may increase the neuromuscular blocking activities of Trimethaphan.
Doxacurium Ambenonium may increase the neuromuscular blocking activities of Doxacurium.
Chloroprocaine Ambenonium may increase the neuromuscular blocking activities of Chloroprocaine.
Tubocurarine Ambenonium may increase the neuromuscular blocking activities of Tubocurarine.
Aclidinium Ambenonium may increase the neuromuscular blocking activities of Aclidinium.
Butyrylthiocholine Ambenonium may increase the neuromuscular blocking activities of Butyrylthiocholine.
Oxybuprocaine Ambenonium may increase the neuromuscular blocking activities of Oxybuprocaine.
Benzonatate Ambenonium may increase the neuromuscular blocking activities of Benzonatate.
Succinylcholine The metabolism of Succinylcholine can be decreased when combined with Ambenonium.
Tramadol The therapeutic efficacy of Tramadol can be decreased when used in combination with Ambenonium.
Trospium The therapeutic efficacy of Trospium can be decreased when used in combination with Ambenonium.
Oxyphenonium The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Ambenonium.
Butabarbital The therapeutic efficacy of Butabarbital can be decreased when used in combination with Ambenonium.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Ambenonium.
Benzatropine The therapeutic efficacy of Benzatropine can be decreased when used in combination with Ambenonium.
Ziprasidone The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Ambenonium.
Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Ambenonium.
Talbutal The therapeutic efficacy of Talbutal can be decreased when used in combination with Ambenonium.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Ambenonium.
Amitriptyline The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Ambenonium.
Ipratropium The therapeutic efficacy of Ipratropium can be decreased when used in combination with Ambenonium.
Methadone The therapeutic efficacy of Methadone can be decreased when used in combination with Ambenonium.
Olanzapine The therapeutic efficacy of Olanzapine can be decreased when used in combination with Ambenonium.
Metixene The therapeutic efficacy of Metixene can be decreased when used in combination with Ambenonium.
Terfenadine The therapeutic efficacy of Terfenadine can be decreased when used in combination with Ambenonium.
Buclizine The therapeutic efficacy of Buclizine can be decreased when used in combination with Ambenonium.
Clozapine The therapeutic efficacy of Clozapine can be decreased when used in combination with Ambenonium.
Doxylamine The therapeutic efficacy of Doxylamine can be decreased when used in combination with Ambenonium.
Trihexyphenidyl The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Ambenonium.
Oxyphencyclimine The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Ambenonium.
Procyclidine The therapeutic efficacy of Procyclidine can be decreased when used in combination with Ambenonium.
Profenamine The therapeutic efficacy of Profenamine can be decreased when used in combination with Ambenonium.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Ambenonium.
Promazine The therapeutic efficacy of Promazine can be decreased when used in combination with Ambenonium.
Hyoscyamine The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Ambenonium.
Cyproheptadine The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Ambenonium.
Imipramine The therapeutic efficacy of Imipramine can be decreased when used in combination with Ambenonium.
Methscopolamine bromide The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Ambenonium.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Ambenonium.
Fluoxetine The therapeutic efficacy of Fluoxetine can be decreased when used in combination with Ambenonium.
Chlorpromazine The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Ambenonium.
Darifenacin The therapeutic efficacy of Darifenacin can be decreased when used in combination with Ambenonium.
Tridihexethyl The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Ambenonium.
Triflupromazine The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Ambenonium.
Dextromethorphan The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Ambenonium.
Anisotropine methylbromide The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Ambenonium.
Nortriptyline The therapeutic efficacy of Nortriptyline can be decreased when used in combination with Ambenonium.
Amoxapine The therapeutic efficacy of Amoxapine can be decreased when used in combination with Ambenonium.
Atropine The therapeutic efficacy of Atropine can be decreased when used in combination with Ambenonium.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Ambenonium.
Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Ambenonium.
Mecamylamine The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Ambenonium.
Pirenzepine The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Ambenonium.
Paroxetine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Ambenonium.
Homatropine methylbromide The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Ambenonium.
Scopolamine The therapeutic efficacy of Scopolamine can be decreased when used in combination with Ambenonium.
Isoflurane The therapeutic efficacy of Isoflurane can be decreased when used in combination with Ambenonium.
Benzquinamide The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Ambenonium.
Clidinium The therapeutic efficacy of Clidinium can be decreased when used in combination with Ambenonium.
Propiomazine The therapeutic efficacy of Propiomazine can be decreased when used in combination with Ambenonium.
Propantheline The therapeutic efficacy of Propantheline can be decreased when used in combination with Ambenonium.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Ambenonium.
Dicyclomine The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Ambenonium.
Biperiden The therapeutic efficacy of Biperiden can be decreased when used in combination with Ambenonium.
Brompheniramine The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Ambenonium.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Ambenonium.
Quinidine The therapeutic efficacy of Quinidine can be decreased when used in combination with Ambenonium.
Amantadine The therapeutic efficacy of Amantadine can be decreased when used in combination with Ambenonium.
Maprotiline The therapeutic efficacy of Maprotiline can be decreased when used in combination with Ambenonium.
Methantheline The therapeutic efficacy of Methantheline can be decreased when used in combination with Ambenonium.
Hexafluronium The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Ambenonium.
Cycrimine The therapeutic efficacy of Cycrimine can be decreased when used in combination with Ambenonium.
Desloratadine The therapeutic efficacy of Desloratadine can be decreased when used in combination with Ambenonium.
Glycopyrronium The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Ambenonium.
Tolterodine The therapeutic efficacy of Tolterodine can be decreased when used in combination with Ambenonium.
Oxybutynin The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Ambenonium.
Promethazine The therapeutic efficacy of Promethazine can be decreased when used in combination with Ambenonium.
Diphenhydramine The therapeutic efficacy of Diphenhydramine can be decreased when used in combination with Ambenonium.
Pentolinium The therapeutic efficacy of Pentolinium can be decreased when used in combination with Ambenonium.
Doxepin The therapeutic efficacy of Doxepin can be decreased when used in combination with Ambenonium.
Flavoxate The therapeutic efficacy of Flavoxate can be decreased when used in combination with Ambenonium.
Desipramine The therapeutic efficacy of Desipramine can be decreased when used in combination with Ambenonium.
Orphenadrine The therapeutic efficacy of Orphenadrine can be decreased when used in combination with Ambenonium.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Ambenonium.
Escitalopram The therapeutic efficacy of Escitalopram can be decreased when used in combination with Ambenonium.
Quetiapine The therapeutic efficacy of Quetiapine can be decreased when used in combination with Ambenonium.
Levacetylmethadol The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Ambenonium.
Diphenidol The therapeutic efficacy of Diphenidol can be decreased when used in combination with Ambenonium.
Aripiprazole The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Ambenonium.
Chlorprothixene The therapeutic efficacy of Chlorprothixene can be decreased when used in combination with Ambenonium.

Target Protein

Acetylcholinesterase ACHE

Referensi & Sumber

Synthesis reference: Kirchner, F.K.; U.S. Patent 3,096,373; July 2,1963; assigned to Sterling Drug Inc.

Contoh Produk & Brand

Produk: 1 • International brands: 1
Produk
  • Mytelase
    Tablet • 10 mg/1 • Oral • US • Approved
International Brands
  • Mysuran

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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