The median lethal dose is higher than the maximum oral dose tested in mice and rats (1825 mg/kg per day). Overdoses up to 31,500 mg of atovaquone have been reported. In one such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Artemether | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Artemether. |
| Lumefantrine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Lumefantrine. |
| Indinavir | Atovaquone can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Ritonavir | The serum concentration of Atovaquone can be decreased when it is combined with Ritonavir. |
| Efavirenz | The serum concentration of Atovaquone can be decreased when it is combined with Efavirenz. |
| Tetracycline | The serum concentration of Atovaquone can be decreased when it is combined with Tetracycline. |
| Etoposide | The serum concentration of Etoposide can be increased when it is combined with Atovaquone. |
| Metoclopramide | Metoclopramide can cause a decrease in the absorption of Atovaquone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Thiethylperazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Thiethylperazine. |
| Promazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Promazine. |
| Prochlorperazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Prochlorperazine. |
| Chlorpromazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Chlorpromazine. |
| Triflupromazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Triflupromazine. |
| Fluphenazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Fluphenazine. |
| Thioridazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Thioridazine. |
| Moricizine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Moricizine. |
| Trifluoperazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Trifluoperazine. |
| Perphenazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Perphenazine. |
| Mesoridazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Mesoridazine. |
| Acetophenazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Acetophenazine. |
| Promethazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Promethazine. |
| Alimemazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Alimemazine. |
| Methotrimeprazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Methotrimeprazine. |
| Periciazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Periciazine. |
| Acepromazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Acepromazine. |
| Aceprometazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Aceprometazine. |
| Pipotiazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Pipotiazine. |
| Thioproperazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Thioproperazine. |
| BL-1020 | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with BL-1020. |
| Cyamemazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Cyamemazine. |
| Methylene blue | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Methylene blue. |
| Propiopromazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Propiopromazine. |
| Perazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Perazine. |
| Butaperazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Butaperazine. |
| Chlorproethazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Chlorproethazine. |
| Thiazinam | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Thiazinam. |
| Dixyrazine | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Dixyrazine. |
| Perphenazine enanthate | The risk or severity of QTc prolongation can be increased when Atovaquone is combined with Perphenazine enanthate. |
| Dapsone | The risk or severity of adverse effects can be increased when Atovaquone is combined with Dapsone. |
| Vemurafenib | The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Atovaquone. |
| Pitolisant | The serum concentration of Atovaquone can be decreased when it is combined with Pitolisant. |
| Metreleptin | The metabolism of Atovaquone can be increased when combined with Metreleptin. |
| Valsartan | The metabolism of Valsartan can be decreased when combined with Atovaquone. |
| Bortezomib | The metabolism of Bortezomib can be decreased when combined with Atovaquone. |
| Troglitazone | The metabolism of Troglitazone can be decreased when combined with Atovaquone. |
| Torasemide | The metabolism of Torasemide can be decreased when combined with Atovaquone. |
| Glimepiride | The metabolism of Glimepiride can be decreased when combined with Atovaquone. |
| Desogestrel | The metabolism of Desogestrel can be decreased when combined with Atovaquone. |
| Bexarotene | The metabolism of Bexarotene can be decreased when combined with Atovaquone. |
| Hydromorphone | The metabolism of Hydromorphone can be decreased when combined with Atovaquone. |
| Indomethacin | The metabolism of Indomethacin can be decreased when combined with Atovaquone. |
| Methadone | The metabolism of Methadone can be decreased when combined with Atovaquone. |
| Trimethadione | The metabolism of Trimethadione can be decreased when combined with Atovaquone. |
| Treprostinil | The metabolism of Treprostinil can be decreased when combined with Atovaquone. |
| Rosiglitazone | The metabolism of Rosiglitazone can be decreased when combined with Atovaquone. |
| Acetohexamide | The metabolism of Acetohexamide can be decreased when combined with Atovaquone. |
| Trimethoprim | The metabolism of Trimethoprim can be decreased when combined with Atovaquone. |
| Nabumetone | The metabolism of Nabumetone can be decreased when combined with Atovaquone. |
| Tenoxicam | The metabolism of Tenoxicam can be decreased when combined with Atovaquone. |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Atovaquone. |
| Montelukast | The metabolism of Montelukast can be decreased when combined with Atovaquone. |
| Fluoxetine | The metabolism of Fluoxetine can be decreased when combined with Atovaquone. |
| Duloxetine | The metabolism of Duloxetine can be decreased when combined with Atovaquone. |
| Celecoxib | The metabolism of Celecoxib can be decreased when combined with Atovaquone. |
| Zidovudine | The metabolism of Zidovudine can be decreased when combined with Atovaquone. |
| Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Atovaquone. |
| Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Atovaquone. |
| Rofecoxib | The metabolism of Rofecoxib can be decreased when combined with Atovaquone. |
| Zafirlukast | The metabolism of Zafirlukast can be decreased when combined with Atovaquone. |
| Piroxicam | The metabolism of Piroxicam can be decreased when combined with Atovaquone. |
| Bosentan | The metabolism of Bosentan can be decreased when combined with Atovaquone. |
| Cinnarizine | The metabolism of Cinnarizine can be decreased when combined with Atovaquone. |
| Valdecoxib | The metabolism of Valdecoxib can be decreased when combined with Atovaquone. |
| Diclofenac | The metabolism of Diclofenac can be decreased when combined with Atovaquone. |
| Doxazosin | The metabolism of Doxazosin can be decreased when combined with Atovaquone. |
| Paramethadione | The metabolism of Paramethadione can be decreased when combined with Atovaquone. |
| Testosterone | The metabolism of Testosterone can be decreased when combined with Atovaquone. |
| Chlorpropamide | The metabolism of Chlorpropamide can be decreased when combined with Atovaquone. |
| Flurbiprofen | The metabolism of Flurbiprofen can be decreased when combined with Atovaquone. |
| Nateglinide | The metabolism of Nateglinide can be decreased when combined with Atovaquone. |
| Zileuton | The metabolism of Zileuton can be decreased when combined with Atovaquone. |
| Etodolac | The metabolism of Etodolac can be decreased when combined with Atovaquone. |
| Clopidogrel | The metabolism of Clopidogrel can be decreased when combined with Atovaquone. |
| Mefenamic acid | The metabolism of Mefenamic acid can be decreased when combined with Atovaquone. |
| Naproxen | The metabolism of Naproxen can be decreased when combined with Atovaquone. |
| Candesartan cilexetil | The metabolism of Candesartan cilexetil can be decreased when combined with Atovaquone. |
| Phenylbutazone | The metabolism of Phenylbutazone can be decreased when combined with Atovaquone. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Atovaquone is combined with Meloxicam. |
| Propofol | The metabolism of Propofol can be decreased when combined with Atovaquone. |
| Tolazamide | The metabolism of Tolazamide can be decreased when combined with Atovaquone. |
| Donepezil | The metabolism of Donepezil can be decreased when combined with Atovaquone. |
| Terbinafine | The metabolism of Terbinafine can be decreased when combined with Atovaquone. |
| Ondansetron | The metabolism of Ondansetron can be decreased when combined with Atovaquone. |
| Buprenorphine | The metabolism of Buprenorphine can be decreased when combined with Atovaquone. |
| Salicylic acid | The metabolism of Salicylic acid can be decreased when combined with Atovaquone. |
| Acetylsalicylic acid | The metabolism of Acetylsalicylic acid can be decreased when combined with Atovaquone. |
| Alosetron | The metabolism of Alosetron can be decreased when combined with Atovaquone. |
| Azelastine | The metabolism of Azelastine can be decreased when combined with Atovaquone. |
| Ramelteon | The metabolism of Ramelteon can be decreased when combined with Atovaquone. |
| Formoterol | The metabolism of Formoterol can be decreased when combined with Atovaquone. |