Peringatan Keamanan

Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.

Cefuroxime

DB01112

small molecule approved

Deskripsi

Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.

Struktur Molekul 2D

Berat 424.385
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 80 minutes following intramuscular or intravenous injection.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).

Metabolisme

The axetil moiety is metabolized to acetaldehyde and acetic acid.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with food. Food increases absorption.

Interaksi Obat

829 Data
Probenecid The serum concentration of Cefuroxime can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefuroxime.
Tenofovir disoproxil Cefuroxime may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefuroxime may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefuroxime may increase the nephrotoxic activities of Tenofovir.
Olanzapine Olanzapine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cimetidine Cimetidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nizatidine Nizatidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ranitidine Ranitidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famotidine Famotidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methantheline Methantheline can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Promethazine Promethazine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doxepin Doxepin can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Asenapine Asenapine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metiamide Metiamide can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxatidine acetate Roxatidine acetate can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lafutidine Lafutidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lavoltidine Lavoltidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Niperotidine Niperotidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Epinastine Epinastine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium The serum concentration of Cefuroxime can be decreased when it is combined with Aluminium.
Magnesium oxide The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium oxide.
Sodium bicarbonate The serum concentration of Cefuroxime can be decreased when it is combined with Sodium bicarbonate.
Aluminum hydroxide The serum concentration of Cefuroxime can be decreased when it is combined with Aluminum hydroxide.
Calcium carbonate The serum concentration of Cefuroxime can be decreased when it is combined with Calcium carbonate.
Magaldrate The serum concentration of Cefuroxime can be decreased when it is combined with Magaldrate.
Magnesium hydroxide The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium hydroxide.
Magnesium trisilicate The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium trisilicate.
Magnesium carbonate The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium carbonate.
Bismuth subnitrate The serum concentration of Cefuroxime can be decreased when it is combined with Bismuth subnitrate.
Magnesium silicate The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium silicate.
Aluminium acetoacetate The serum concentration of Cefuroxime can be decreased when it is combined with Aluminium acetoacetate.
Hydrotalcite The serum concentration of Cefuroxime can be decreased when it is combined with Hydrotalcite.
Magnesium peroxide The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium peroxide.
Almasilate The serum concentration of Cefuroxime can be decreased when it is combined with Almasilate.
Aluminium glycinate The serum concentration of Cefuroxime can be decreased when it is combined with Aluminium glycinate.
Aloglutamol The serum concentration of Cefuroxime can be decreased when it is combined with Aloglutamol.
Calcium silicate The serum concentration of Cefuroxime can be decreased when it is combined with Calcium silicate.
Aluminium phosphate The serum concentration of Cefuroxime can be decreased when it is combined with Aluminium phosphate.
Pantoprazole The serum concentration of Cefuroxime can be decreased when it is combined with Pantoprazole.
Rabeprazole The serum concentration of Cefuroxime can be decreased when it is combined with Rabeprazole.
Omeprazole The serum concentration of Cefuroxime can be decreased when it is combined with Omeprazole.
Lansoprazole The serum concentration of Cefuroxime can be decreased when it is combined with Lansoprazole.
Esomeprazole The serum concentration of Cefuroxime can be decreased when it is combined with Esomeprazole.
Dexlansoprazole The serum concentration of Cefuroxime can be decreased when it is combined with Dexlansoprazole.
Dexrabeprazole The serum concentration of Cefuroxime can be decreased when it is combined with Dexrabeprazole.
Sodium zirconium cyclosilicate The serum concentration of Cefuroxime can be decreased when it is combined with Sodium zirconium cyclosilicate.
Vonoprazan The serum concentration of Cefuroxime can be decreased when it is combined with Vonoprazan.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefuroxime.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefuroxime.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefuroxime.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefuroxime.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefuroxime.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefuroxime.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefuroxime.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefuroxime.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefuroxime.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefuroxime.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefuroxime.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefuroxime.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefuroxime.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefuroxime.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefuroxime.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefuroxime.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefuroxime.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefuroxime.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefuroxime.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefuroxime.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefuroxime.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefuroxime.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefuroxime.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefuroxime.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefuroxime.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefuroxime.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefuroxime.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefuroxime.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefuroxime.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefuroxime.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefuroxime.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefuroxime.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefuroxime is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefuroxime.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefuroxime.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefuroxime.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefuroxime.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefuroxime.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefuroxime.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefuroxime.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefuroxime.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefuroxime.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefuroxime.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefuroxime.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefapirin.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefprozil.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Lumiracoxib.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefamandole.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefazolin.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefonicid.

Target Protein

Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Vijay Kumar Handa, Ramesh Dandala, Jag Mohan Khanna, "Process for the preparation of cefuroxime." U.S. Patent US6235896, issued February, 1976.
Artikel (PubMed)
  • PMID: 8799689
    Perry CM, Brogden RN: Cefuroxime axetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1996 Jul;52(1):125-58.

Contoh Produk & Brand

Produk: 213 • International brands: 7
Produk
  • Apo-cefuroxime
    Tablet • 250 mg • Oral • Canada • Generic • Approved
  • Apo-cefuroxime
    Tablet • 500 mg • Oral • Canada • Generic • Approved
  • Auro-cefuroxime
    Tablet • 250 mg • Oral • Canada • Generic • Approved
  • Auro-cefuroxime
    Tablet • 500 mg • Oral • Canada • Generic • Approved
  • Ceftin
    Tablet, film coated • 250 mg/1 • Oral • US • Approved
  • Ceftin
    Powder, for suspension • 250 mg/5mL • Oral • US • Approved
  • Ceftin
    Tablet, film coated • 500 mg/1 • Oral • US • Approved
  • Ceftin
    Powder, for suspension • 125 mg/5mL • Oral • US • Approved
Menampilkan 8 dari 213 produk.
International Brands
  • Cefurax — Lindopharm
  • Elobact — GlaxoSmithKline
  • Oraxim — Malesci
  • Sharox — Fahrenheit
  • Supacef — GlaxoSmithKline
  • Zinacef danmark
  • Zinnat — GlaxoSmithKline

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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