Peringatan Keamanan

Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.

Trilostane

DB01108

small molecule approved investigational vet_approved withdrawn

Deskripsi

Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994.

Struktur Molekul 2D

Berat 329.4333
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1036 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Trilostane.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Trilostane.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Trilostane.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Trilostane.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Trilostane.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Trilostane.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Trilostane.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Trilostane.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Trilostane.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Trilostane.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Trilostane.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Trilostane.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Trilostane.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Trilostane.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Trilostane.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Trilostane.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Trilostane.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Trilostane.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Trilostane.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Trilostane.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Trilostane.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Trilostane.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Trilostane.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Trilostane.
Cladribine Trilostane may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Trilostane.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Trilostane.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Trilostane.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Trilostane.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Trilostane.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Trilostane.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Trilostane.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Trilostane.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Trilostane.
Vinorelbine The risk or severity of adverse effects can be increased when Vinorelbine is combined with Trilostane.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Trilostane.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Trilostane.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Trilostane.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Trilostane.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Trilostane.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Trilostane.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Trilostane.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Trilostane.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Trilostane.
Vincristine The risk or severity of adverse effects can be increased when Vincristine is combined with Trilostane.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Trilostane.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Trilostane.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Trilostane.
Methotrexate The risk or severity of adverse effects can be increased when Methotrexate is combined with Trilostane.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Trilostane.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Trilostane.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Trilostane.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Trilostane.
Irinotecan The risk or severity of adverse effects can be increased when Irinotecan is combined with Trilostane.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Trilostane.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Trilostane.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Trilostane.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Trilostane.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Trilostane.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Trilostane.
Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Trilostane.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Trilostane.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Trilostane.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Trilostane.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Trilostane.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Trilostane.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Trilostane.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Trilostane.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Trilostane.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Trilostane.
Procarbazine The risk or severity of adverse effects can be increased when Trilostane is combined with Procarbazine.
Arsenic trioxide The risk or severity of adverse effects can be increased when Trilostane is combined with Arsenic trioxide.
Idarubicin The risk or severity of adverse effects can be increased when Trilostane is combined with Idarubicin.
Estramustine The risk or severity of adverse effects can be increased when Trilostane is combined with Estramustine.
Lomustine The risk or severity of adverse effects can be increased when Trilostane is combined with Lomustine.
Eculizumab The risk or severity of adverse effects can be increased when Trilostane is combined with Eculizumab.
Decitabine The risk or severity of adverse effects can be increased when Trilostane is combined with Decitabine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Trilostane.
Stepronin The risk or severity of adverse effects can be increased when Trilostane is combined with Stepronin.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Trilostane is combined with Hydroxychloroquine.
Castanospermine The risk or severity of adverse effects can be increased when Trilostane is combined with Castanospermine.
Vorinostat The risk or severity of adverse effects can be increased when Trilostane is combined with Vorinostat.
2-Methoxyethanol The risk or severity of adverse effects can be increased when Trilostane is combined with 2-Methoxyethanol.
Brequinar The risk or severity of adverse effects can be increased when Trilostane is combined with Brequinar.
Pirfenidone The risk or severity of adverse effects can be increased when Trilostane is combined with Pirfenidone.
Belinostat The risk or severity of adverse effects can be increased when Trilostane is combined with Belinostat.
Trabectedin The risk or severity of adverse effects can be increased when Trilostane is combined with Trabectedin.
Interferon alfa The risk or severity of adverse effects can be increased when Trilostane is combined with Interferon alfa.
Glatiramer The risk or severity of adverse effects can be increased when Trilostane is combined with Glatiramer.
Briakinumab The risk or severity of adverse effects can be increased when Trilostane is combined with Briakinumab.
Human interferon omega-1 The risk or severity of adverse effects can be increased when Trilostane is combined with Human interferon omega-1.
Panobinostat The risk or severity of adverse effects can be increased when Trilostane is combined with Panobinostat.
Mepolizumab The risk or severity of adverse effects can be increased when Trilostane is combined with Mepolizumab.
Abetimus The risk or severity of adverse effects can be increased when Trilostane is combined with Abetimus.
Belatacept The risk or severity of adverse effects can be increased when Trilostane is combined with Belatacept.
Bendamustine The risk or severity of adverse effects can be increased when Trilostane is combined with Bendamustine.
Cabazitaxel The risk or severity of adverse effects can be increased when Trilostane is combined with Cabazitaxel.
Pralatrexate The risk or severity of adverse effects can be increased when Trilostane is combined with Pralatrexate.
Wortmannin The risk or severity of adverse effects can be increased when Trilostane is combined with Wortmannin.
Eribulin The risk or severity of adverse effects can be increased when Trilostane is combined with Eribulin.

Target Protein

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 HSD3B2
Estrogen receptor ESR1
Estrogen receptor beta ESR2

Referensi & Sumber

Synthesis reference: Walter Elger, Sybille Beier, Beate Kosub, Marianne Faehnrich, Krzysztof Chwalisz, Syed Hamiduddin Hasan, Gordon Oliver Potts, "Combined use of an antigestagen and a progesterone synthesis inhibitor of the trilostane and epostane type." U.S. Patent US5795881, issued June, 1987.
Artikel (PubMed)
  • PMID: 233687
    Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Desopan
  • Modrastane
  • Modrenal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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