Peringatan Keamanan

Adverse effects include visual disturbances, dry mouth, cough, nausea, eyelid edema and lacrimation.

Levocabastine

DB01106

small molecule approved investigational

Deskripsi

Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.

Struktur Molekul 2D

Berat 420.528
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 36 hours (after oral administration)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

After instillation in the eye, levocabastine is systemically absorbed, albeit at low levels.

Metabolisme

Mostly unchanged. 10 to 20% is metabolized to the acylglucuronide of levocabastine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

438 Data
Buprenorphine Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Hydrocodone Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Levocabastine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Levocabastine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Mirtazapine Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Orphenadrine Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Pramipexole Levocabastine may increase the sedative activities of Pramipexole.
Ropinirole Levocabastine may increase the sedative activities of Ropinirole.
Rotigotine Levocabastine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Levocabastine.
Suvorexant Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Thalidomide Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Benzylpenicilloyl polylysine Levocabastine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Levocabastine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Levocabastine.
Ethanol Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
Fluvoxamine The risk or severity of adverse effects can be increased when Levocabastine is combined with Fluvoxamine.
Duloxetine The risk or severity of adverse effects can be increased when Levocabastine is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Levocabastine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Levocabastine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Levocabastine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Levocabastine is combined with Nefazodone.
Zimelidine The risk or severity of adverse effects can be increased when Levocabastine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Levocabastine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Levocabastine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Levocabastine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Levocabastine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Levocabastine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Levocabastine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Levocabastine is combined with Alaproclate.
Citalopram The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Citalopram.
Escitalopram The risk or severity of adverse effects can be increased when Levocabastine is combined with Escitalopram.
Benzatropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Levocabastine.
Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Levocabastine.
Buclizine The risk or severity of QTc prolongation can be increased when Buclizine is combined with Levocabastine.
Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Levocabastine.
Nortriptyline The risk or severity of QTc prolongation can be increased when Nortriptyline is combined with Levocabastine.
Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Levocabastine.
Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Levocabastine.
Nicardipine The risk or severity of QTc prolongation can be increased when Nicardipine is combined with Levocabastine.
Brompheniramine The risk or severity of QTc prolongation can be increased when Brompheniramine is combined with Levocabastine.
Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Levocabastine.
Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Levocabastine.
Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Levocabastine.
Diphenhydramine The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Levocabastine.
Doxepin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Doxepin.
Desipramine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Desipramine.
Aripiprazole The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Aripiprazole.
Chlorprothixene The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Chlorprothixene.
Solifenacin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Solifenacin.
Trimebutine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Trimebutine.
Dosulepin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Dosulepin.
Zopiclone The risk or severity of adverse effects can be increased when Levocabastine is combined with Zopiclone.
Leuprolide The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Leuprolide.
Goserelin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Goserelin.
Erythromycin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Erythromycin.
Azithromycin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Azithromycin.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Moxifloxacin.
Ranolazine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Ranolazine.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Sulfisoxazole.
Amitriptyline The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Amitriptyline.
Diltiazem The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Diltiazem.
Clozapine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Clozapine.
Sulpiride The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Sulpiride.
Nimodipine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Nimodipine.
Promazine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Promazine.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Prochlorperazine.
Imipramine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Imipramine.
Chlorpromazine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Chlorpromazine.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Levocabastine.
Ciprofloxacin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Ciprofloxacin.
Fluorouracil The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Fluorouracil.
Perflutren The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Perflutren.
Cinnarizine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Cinnarizine.
Atropine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Atropine.
Chloroquine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Chloroquine.
Efavirenz The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Efavirenz.
Adenosine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Adenosine.
Pentamidine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Pentamidine.
Gadobenic acid The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Gadobenic acid.
Carbinoxamine The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Carbinoxamine.
Dolasetron The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Dolasetron.
Roxithromycin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Roxithromycin.
Nalidixic acid The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Nalidixic acid.
Cinoxacin The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Cinoxacin.
Loperamide The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Loperamide.
Granisetron The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Granisetron.
Ondansetron The risk or severity of QTc prolongation can be increased when Levocabastine is combined with Ondansetron.

Target Protein

Histamine H1 receptor HRH1
Neurotensin receptor type 2 NTSR2

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 4 • International brands: 0
Produk
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  • Livostin Eye Drops
    Solution / drops; Suspension • 0.5 mg / mL • Ophthalmic • Canada • Approved
  • Livostin Sus Nas 0.5mg/ml
    Spray; Suspension • 0.05 mg / act • Nasal • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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