Peringatan Keamanan

LD50 = 1100 mg/kg (rat, oral), 228 mg/kg (mouse, oral)

Pimozide

DB01100

small molecule approved

Deskripsi

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Struktur Molekul 2D

Berat 461.5462
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 29 ± 10 hours (single-dose study of healthy volunteers).
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Greater than 50% absorption after oral administration. Serum peak appears 6-8 hours post ingestion.

Metabolisme

Notable first-pass metabolism in the liver, primarily by N-dealkylation via the cytochrome P450 isoenzymes CYP3A and CYP1A2 (and possibly CYP2D6). The activity of the two major metabolites has not been determined.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid grapefruit products. Grapefruit inhibits CYP3A4 and, therefore, may increase pimozide serum levels.
  • 2. Exercise caution with St. John's Wort.

Interaksi Obat

1577 Data
Modafinil The metabolism of Pimozide can be increased when combined with Modafinil.
Armodafinil The metabolism of Pimozide can be increased when combined with Armodafinil.
Phenytoin The metabolism of Pimozide can be increased when combined with Phenytoin.
Fosphenytoin The metabolism of Pimozide can be increased when combined with Fosphenytoin.
Deferasirox The serum concentration of Pimozide can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Pimozide can be increased when it is combined with Peginterferon alfa-2b.
Fluvoxamine The risk or severity of QTc prolongation can be increased when Fluvoxamine is combined with Pimozide.
Citalopram The risk or severity of QTc prolongation and ventricular arrhythmias can be increased when Citalopram is combined with Pimozide.
Duloxetine The risk or severity of QTc prolongation can be increased when Duloxetine is combined with Pimozide.
Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Pimozide.
Paroxetine The risk or severity of QTc prolongation can be increased when Paroxetine is combined with Pimozide.
Sibutramine The risk or severity of QTc prolongation can be increased when Sibutramine is combined with Pimozide.
Nefazodone The risk or severity of QTc prolongation can be increased when Nefazodone is combined with Pimozide.
Zimelidine The risk or severity of QTc prolongation can be increased when Zimelidine is combined with Pimozide.
Dapoxetine The risk or severity of QTc prolongation can be increased when Dapoxetine is combined with Pimozide.
Milnacipran The risk or severity of QTc prolongation can be increased when Milnacipran is combined with Pimozide.
Desvenlafaxine The risk or severity of QTc prolongation can be increased when Desvenlafaxine is combined with Pimozide.
Seproxetine The risk or severity of QTc prolongation can be increased when Seproxetine is combined with Pimozide.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Pimozide.
Indalpine The risk or severity of QTc prolongation can be increased when Indalpine is combined with Pimozide.
Ritanserin The risk or severity of QTc prolongation can be increased when Ritanserin is combined with Pimozide.
Alaproclate The risk or severity of QTc prolongation can be increased when Alaproclate is combined with Pimozide.
Leflunomide The serum concentration of Pimozide can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Pimozide can be decreased when it is combined with Teriflunomide.
Buprenorphine Pimozide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Pimozide.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Hydrocodone Pimozide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Pimozide can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Pimozide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Pimozide may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Mirtazapine Pimozide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Orphenadrine Pimozide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Pimozide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Rotigotine Pimozide may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Pimozide.
Sodium oxybate Pimozide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Pimozide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Thalidomide Pimozide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Pimozide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Pimozide.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Pimozide.
Erythromycin The risk or severity of QTc prolongation and ventricular arrhythmias can be increased when Erythromycin is combined with Pimozide.
Azithromycin The risk or severity of QTc prolongation and ventricular arrhythmias can be increased when Azithromycin is combined with Pimozide.
Roxithromycin The risk or severity of QTc prolongation and ventricular arrhythmias can be increased when Roxithromycin is combined with Pimozide.
Telithromycin The risk or severity of QTc prolongation and ventricular arrhythmias can be increased when Telithromycin is combined with Pimozide.
Clarithromycin The risk or severity of QTc prolongation and ventricular arrhythmias can be increased when Clarithromycin is combined with Pimozide.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Pimozide.
Colchicine The metabolism of Colchicine can be decreased when combined with Pimozide.
Fentanyl The metabolism of Pimozide can be decreased when combined with Fentanyl.
Iloperidone The risk or severity of QTc prolongation can be increased when Pimozide is combined with Iloperidone.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Pimozide.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Pimozide.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Pimozide.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Pimozide.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Pimozide.
Amisulpride Pimozide may increase the antipsychotic activities of Amisulpride.
Methylphenidate The risk or severity of adverse effects can be increased when Pimozide is combined with Methylphenidate.
Dexmethylphenidate The risk or severity of adverse effects can be increased when Pimozide is combined with Dexmethylphenidate.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Pimozide.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with Pimozide.
Sulpiride Pimozide may increase the antipsychotic activities of Sulpiride.
Metreleptin The metabolism of Pimozide can be increased when combined with Metreleptin.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Pimozide.
Lithium citrate Lithium citrate may increase the neurotoxic activities of Pimozide.
Lithium hydroxide Lithium hydroxide may increase the neurotoxic activities of Pimozide.
Mequitazine Pimozide may increase the arrhythmogenic activities of Mequitazine.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Pimozide.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Pimozide.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Pimozide.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Pimozide.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Pimozide.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Pimozide.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Pimozide.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Pimozide.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Pimozide.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Pimozide.
Mifepristone The serum concentration of Pimozide can be increased when it is combined with Mifepristone.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Pimozide.
Crizotinib The metabolism of Pimozide can be decreased when combined with Crizotinib.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Pimozide.
Mirabegron The serum concentration of Pimozide can be increased when it is combined with Mirabegron.
Abiraterone The metabolism of Pimozide can be decreased when combined with Abiraterone.
Rolapitant The metabolism of Pimozide can be decreased when combined with Rolapitant.
Cyproterone acetate The metabolism of Pimozide can be increased when combined with Cyproterone acetate.
Ethanol Pimozide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Pimozide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
Carbidopa The therapeutic efficacy of Carbidopa can be decreased when used in combination with Pimozide.
Metixene The therapeutic efficacy of Metixene can be decreased when used in combination with Pimozide.
Trihexyphenidyl The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Pimozide.
Procyclidine The therapeutic efficacy of Procyclidine can be decreased when used in combination with Pimozide.
Profenamine The therapeutic efficacy of Profenamine can be decreased when used in combination with Pimozide.
Memantine The therapeutic efficacy of Memantine can be decreased when used in combination with Pimozide.
3,5-Dinitrocatechol The therapeutic efficacy of 3,5-Dinitrocatechol can be decreased when used in combination with Pimozide.

Target Protein

D(2) dopamine receptor DRD2
D(3) dopamine receptor DRD3
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
Calmodulin CALM1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 14 • International brands: 3
Produk
  • Orap
    Tablet • 2 mg/1 • Oral • US • Approved
  • Orap
    Tablet • 1 mg/1 • Oral • US • Approved
  • Orap
    Tablet • 2 mg/1 • Oral • US • Approved
  • Orap
    Tablet • 2 mg • Oral • Canada • Approved
  • Orap
    Tablet • 4 mg • Oral • Canada • Approved
  • Orap Tab 10mg
    Tablet • 10 mg / tab • Oral • Canada • Approved
  • Pimozide
    Tablet • 1 mg/1 • Oral • US • Generic • Approved
  • Pimozide
    Tablet • 2 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 14 produk.
International Brands
  • Halomonth
  • Neoperidole
  • Opiran

Sekuens Gen/Protein (FASTA)

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