Hesperetin

DB01094

small molecule experimental

Deskripsi

Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.

Struktur Molekul 2D

Berat 302.2788
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

389 Data
Deferasirox The serum concentration of Hesperetin can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Hesperetin can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Hesperetin can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Hesperetin can be decreased when it is combined with Teriflunomide.
Abiraterone The serum concentration of Hesperetin can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Hesperetin can be increased when combined with Cyproterone acetate.
Carbamazepine The metabolism of Hesperetin can be increased when combined with Carbamazepine.
Primidone The metabolism of Hesperetin can be increased when combined with Primidone.
Rifampin The metabolism of Hesperetin can be increased when combined with Rifampicin.
Albendazole The metabolism of Hesperetin can be increased when combined with Albendazole.
Caffeine The metabolism of Hesperetin can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Hesperetin can be decreased when combined with Moxifloxacin.
Lidocaine The metabolism of Hesperetin can be decreased when combined with Lidocaine.
Mexiletine The metabolism of Hesperetin can be decreased when combined with Mexiletine.
Imipramine The metabolism of Hesperetin can be decreased when combined with Imipramine.
Alosetron The metabolism of Hesperetin can be decreased when combined with Alosetron.
Ketoconazole The metabolism of Hesperetin can be decreased when combined with Ketoconazole.
Gatifloxacin The metabolism of Hesperetin can be decreased when combined with Gatifloxacin.
Lobeglitazone The metabolism of Hesperetin can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Hesperetin can be decreased when combined with Pazufloxacin.
Osilodrostat The metabolism of Hesperetin can be decreased when combined with Osilodrostat.
Osimertinib The serum concentration of Hesperetin can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Hesperetin can be increased when it is combined with Vemurafenib.
Folic acid Hesperetin may decrease the excretion rate of Folic acid which could result in a higher serum level.
Pravastatin Hesperetin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Conjugated estrogens Hesperetin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Gefitinib Hesperetin may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Sorafenib The metabolism of Hesperetin can be decreased when combined with Sorafenib.
Allopurinol Hesperetin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Cerivastatin Hesperetin may decrease the excretion rate of Cerivastatin which could result in a higher serum level.
Teniposide Hesperetin may decrease the excretion rate of Teniposide which could result in a higher serum level.
Prazosin Hesperetin may decrease the excretion rate of Prazosin which could result in a higher serum level.
Raloxifene Hesperetin may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Celecoxib Hesperetin may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Zidovudine Hesperetin may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Ritonavir Hesperetin may decrease the excretion rate of Ritonavir which could result in a higher serum level.
Oxaliplatin Hesperetin may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Vincristine Hesperetin may decrease the excretion rate of Vincristine which could result in a higher serum level.
Fluorouracil Hesperetin may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Methotrexate Hesperetin may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Ivermectin Hesperetin may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Imatinib Hesperetin may decrease the excretion rate of Imatinib which could result in a higher serum level.
Testosterone Hesperetin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Clofarabine Hesperetin may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Sumatriptan Hesperetin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tamoxifen Hesperetin may decrease the excretion rate of Tamoxifen which could result in a higher serum level.
Mycophenolate mofetil Hesperetin may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
Daunorubicin Hesperetin may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Hesperetin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Lamivudine Hesperetin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Hesperetin may decrease the excretion rate of Riluzole which could result in a higher serum level.
Irinotecan Hesperetin may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Etoposide Hesperetin may decrease the excretion rate of Etoposide which could result in a higher serum level.
Sulfasalazine Hesperetin may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Dactinomycin Hesperetin may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Ezetimibe Hesperetin may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Doxorubicin Hesperetin may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Glyburide Hesperetin may decrease the excretion rate of Glyburide which could result in a higher serum level.
Topotecan Hesperetin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rosuvastatin Hesperetin may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Mitoxantrone Hesperetin may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Dasatinib Hesperetin may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Alvocidib Hesperetin may decrease the excretion rate of Alvocidib which could result in a higher serum level.
Camptothecin Hesperetin may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Nilotinib Hesperetin may decrease the excretion rate of Nilotinib which could result in a higher serum level.
Rivaroxaban Hesperetin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Simeprevir The metabolism of Hesperetin can be decreased when combined with Simeprevir.
Pazopanib Hesperetin may decrease the excretion rate of Pazopanib which could result in a higher serum level.
Apixaban Hesperetin may decrease the excretion rate of Apixaban which could result in a higher serum level.
Ponatinib Hesperetin may decrease the excretion rate of Ponatinib which could result in a higher serum level.
Dabrafenib Hesperetin may decrease the excretion rate of Dabrafenib which could result in a higher serum level.
Afatinib Hesperetin may decrease the excretion rate of Afatinib which could result in a higher serum level.
Dolutegravir Hesperetin may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Riociguat Hesperetin may decrease the excretion rate of Riociguat which could result in a higher serum level.
Sofosbuvir Hesperetin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Idelalisib Hesperetin may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Palbociclib Hesperetin may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lenvatinib Hesperetin may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Fimasartan Hesperetin may decrease the excretion rate of Fimasartan which could result in a higher serum level.
Ombitasvir Hesperetin may decrease the excretion rate of Ombitasvir which could result in a higher serum level.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Hesperetin.
Venetoclax Hesperetin may decrease the excretion rate of Venetoclax which could result in a higher serum level.
Velpatasvir Hesperetin may decrease the excretion rate of Velpatasvir which could result in a higher serum level.
Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Hesperetin.
Revefenacin Hesperetin may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Delafloxacin Hesperetin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Duvelisib Hesperetin may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Dacomitinib Hesperetin may decrease the excretion rate of Dacomitinib which could result in a higher serum level.
Glasdegib Hesperetin may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Abemaciclib Hesperetin may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Voxilaprevir Hesperetin may decrease the excretion rate of Voxilaprevir which could result in a higher serum level.
Brigatinib Hesperetin may decrease the excretion rate of Brigatinib which could result in a higher serum level.
Rucaparib Hesperetin may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Copanlisib Hesperetin may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Lusutrombopag Hesperetin may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Enasidenib Hesperetin may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Pibrentasvir Hesperetin may decrease the excretion rate of Pibrentasvir which could result in a higher serum level.
Glecaprevir Hesperetin may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Testosterone cypionate Hesperetin may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
Testosterone enanthate Hesperetin may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.

Target Protein

Diacylglycerol O-acyltransferase 1 DGAT1
Microsomal triglyceride transfer protein large subunit MTTP
Sterol O-acyltransferase 1 SOAT1
Sex hormone-binding globulin SHBG
Sterol O-acyltransferase 2 SOAT2

Referensi & Sumber

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