The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Dimethyl sulfoxide. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Dimethyl sulfoxide. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Dimethyl sulfoxide. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Dimethyl sulfoxide. |
| Fentanyl | Fentanyl may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Dimethyl sulfoxide. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Dimethyl sulfoxide. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Dimethyl sulfoxide. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Dimethyl sulfoxide. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Dimethyl sulfoxide. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Dimethyl sulfoxide. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Dimethyl sulfoxide. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Dimethyl sulfoxide. |
| Dexrazoxane | The therapeutic efficacy of Dexrazoxane can be decreased when used in combination with Dimethyl sulfoxide. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Dimethyl sulfoxide. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Dimethyl sulfoxide. |
| Sulindac | The therapeutic efficacy of Sulindac can be decreased when used in combination with Dimethyl sulfoxide. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Dimethyl sulfoxide. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Dimethyl sulfoxide. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Dimethyl sulfoxide. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Dimethyl sulfoxide. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Dimethyl sulfoxide. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Dimethyl sulfoxide. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Dimethyl sulfoxide. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Dimethyl sulfoxide. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Dimethyl sulfoxide. |
| Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Dimethyl sulfoxide. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be decreased when combined with Dimethyl sulfoxide. |
| Icosapent | Icosapent may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |