Ouabain

DB01092

small molecule approved

Deskripsi

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.

Struktur Molekul 2D

Berat 584.6525
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

563 Data
Amiodarone The serum concentration of Ouabain can be increased when it is combined with Amiodarone.
Amphotericin B The risk or severity of adverse effects can be increased when Amphotericin B is combined with Ouabain.
Clonidine Clonidine may increase the atrioventricular blocking (AV block) activities of Ouabain.
Edrophonium Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Ouabain.
Itraconazole The serum concentration of Ouabain can be increased when it is combined with Itraconazole.
Kaolin The serum concentration of Ouabain can be decreased when it is combined with Kaolin.
Midodrine Ouabain may increase the bradycardic, atrioventricular blocking (AV block), and arrhythmogenic activities of Midodrine.
Propafenone The serum concentration of Ouabain can be increased when it is combined with Propafenone.
Quinine The serum concentration of Ouabain can be increased when it is combined with Quinine.
Quinidine The serum concentration of Ouabain can be increased when it is combined with Quinidine.
Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Ouabain.
Telmisartan The serum concentration of Ouabain can be increased when it is combined with Telmisartan.
Succinic acid The excretion of Succinic acid can be decreased when combined with Ouabain.
Citrulline The excretion of Citrulline can be decreased when combined with Ouabain.
Pravastatin The excretion of Pravastatin can be decreased when combined with Ouabain.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Ouabain.
Cefotiam The excretion of Cefotiam can be decreased when combined with Ouabain.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Ouabain.
Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Ouabain.
Piperacillin The excretion of Piperacillin can be decreased when combined with Ouabain.
Indomethacin The excretion of Indomethacin can be decreased when combined with Ouabain.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Ouabain.
Trifluridine The excretion of Trifluridine can be decreased when combined with Ouabain.
Allopurinol The excretion of Allopurinol can be decreased when combined with Ouabain.
Zidovudine The excretion of Zidovudine can be decreased when combined with Ouabain.
Cimetidine The excretion of Cimetidine can be decreased when combined with Ouabain.
Cefdinir The excretion of Cefdinir can be decreased when combined with Ouabain.
Methotrexate The excretion of Methotrexate can be decreased when combined with Ouabain.
Cephalexin The excretion of Cephalexin can be decreased when combined with Ouabain.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Ouabain.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Ouabain.
Leucovorin The excretion of Leucovorin can be decreased when combined with Ouabain.
Fluorescein The excretion of Fluorescein can be decreased when combined with Ouabain.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Ouabain.
Tetracycline The excretion of Tetracycline can be decreased when combined with Ouabain.
Estradiol The excretion of Estradiol can be decreased when combined with Ouabain.
Acyclovir The excretion of Acyclovir can be decreased when combined with Ouabain.
Cefaclor The excretion of Cefaclor can be decreased when combined with Ouabain.
Ranitidine The excretion of Ranitidine can be decreased when combined with Ouabain.
Quinapril The excretion of Quinapril can be decreased when combined with Ouabain.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Ouabain.
Famotidine The excretion of Famotidine can be decreased when combined with Ouabain.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Ouabain.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Ouabain.
Captopril The excretion of Captopril can be decreased when combined with Ouabain.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Ouabain.
Cefazolin The excretion of Cefazolin can be decreased when combined with Ouabain.
Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Ouabain.
Cefacetrile The excretion of Cefacetrile can be decreased when combined with Ouabain.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Ouabain.
Tazobactam The excretion of Tazobactam can be decreased when combined with Ouabain.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Ouabain.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Ouabain.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Ouabain.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Ouabain.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Ouabain.
Doripenem The excretion of Doripenem can be decreased when combined with Ouabain.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Ouabain.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Ouabain.
Cefaloridine The excretion of Cefaloridine can be decreased when combined with Ouabain.
Avibactam The excretion of Avibactam can be decreased when combined with Ouabain.
Silibinin The excretion of Silibinin can be decreased when combined with Ouabain.
Tenofovir alafenamide The excretion of Tenofovir alafenamide can be decreased when combined with Ouabain.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Ouabain.
Relebactam The excretion of Relebactam can be decreased when combined with Ouabain.
Tenofovir The excretion of Tenofovir can be decreased when combined with Ouabain.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Ouabain.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Ouabain.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Ouabain.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Ouabain.
Tolevamer The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Ouabain.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Ouabain.
Parathyroid hormone The risk or severity of adverse effects can be increased when Parathyroid hormone is combined with Ouabain.
Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Ouabain.
Calcitriol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcitriol is combined with Ouabain.
Calcifediol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcifediol is combined with Ouabain.
Ergocalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Ergocalciferol is combined with Ouabain.
Cholecalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Cholecalciferol is combined with Ouabain.
Paricalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Paricalcitol is combined with Ouabain.
Dihydrotachysterol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Dihydrotachysterol is combined with Ouabain.
Alfacalcidol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Alfacalcidol is combined with Ouabain.
Seocalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Seocalcitol is combined with Ouabain.
Inecalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Ouabain.
Becocalcidiol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Becocalcidiol is combined with Ouabain.
Eldecalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Eldecalcitol is combined with Ouabain.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Ouabain.
Elocalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Elocalcitol is combined with Ouabain.
Maxacalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Maxacalcitol is combined with Ouabain.
Doxercalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Doxercalciferol is combined with Ouabain.
Vitamin D The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Vitamin D is combined with Ouabain.
1alpha-Hydroxyvitamin D5 The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when 1alpha-Hydroxyvitamin D5 is combined with Ouabain.
Previtamin D(3) The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Previtamin D(3) is combined with Ouabain.
Esmolol Esmolol may increase the bradycardic activities of Ouabain.
Betaxolol Betaxolol may increase the bradycardic activities of Ouabain.
Metoprolol Metoprolol may increase the bradycardic activities of Ouabain.
Atenolol Atenolol may increase the bradycardic activities of Ouabain.
Timolol Timolol may increase the bradycardic activities of Ouabain.
Sotalol Sotalol may increase the bradycardic activities of Ouabain.
Propranolol Propranolol may increase the bradycardic activities of Ouabain.

Target Protein

Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2
Sodium/potassium-transporting ATPase subunit alpha-3 ATP1A3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11929882
    Gao J, Wymore RS, Wang Y, Gaudette GR, Krukenkamp IB, Cohen IS, Mathias RT: Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. J Gen Physiol. 2002 Apr;119(4):297-312.
  • PMID: 15009217
    Saunders R, Scheiner-Bobis G: Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump. Eur J Biochem. 2004 Mar;271(5):1054-62.
  • PMID: 1648735
    Hamlyn JM, Blaustein MP, Bova S, DuCharme DW, Harris DW, Mandel F, Mathews WR, Ludens JH: Identification and characterization of a ouabain-like compound from human plasma. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6259-63.
  • PMID: 12763919
    Hamlyn JM, Laredo J, Shah JR, Lu ZR, Hamilton BP: 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications. Ann N Y Acad Sci. 2003 Apr;986:685-93.
  • PMID: 8033829
    Laredo J, Hamilton BP, Hamlyn JM: Ouabain is secreted by bovine adrenocortical cells. Endocrinology. 1994 Aug;135(2):794-7.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Strodival

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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