Peringatan Keamanan

Somnolence and malaise have been reported following daily oral administration.

Emedastine

DB01084

small molecule approved

Deskripsi

Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.

Struktur Molekul 2D

Berat 302.4145
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life in the plasma is 3-4 hours following oral administration.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Ophthalmic use of emedastine usually does not produce measurable plasma concentrations.

Metabolisme

Two primary metabolites, 5-hydroxyemedastine and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. Minor metabolites include the 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide.

Rute Eliminasi

Following oral administration, approximately 44% of the total dose can be recovered in the urine over the 24-hour period, with only 3.6% of the dose excreted as unchanged form. Two primary metabolites, 5- and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms.

Interaksi Obat

396 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Emedastine.
Benzylpenicilloyl polylysine Emedastine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Emedastine.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Emedastine.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Emedastine.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Emedastine.
Amphetamine Amphetamine may decrease the sedative activities of Emedastine.
Phentermine Phentermine may decrease the sedative activities of Emedastine.
Pseudoephedrine Pseudoephedrine may decrease the sedative activities of Emedastine.
Benzphetamine Benzphetamine may decrease the sedative activities of Emedastine.
Diethylpropion Diethylpropion may decrease the sedative activities of Emedastine.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Emedastine.
Mephentermine Mephentermine may decrease the sedative activities of Emedastine.
MMDA MMDA may decrease the sedative activities of Emedastine.
Midomafetamine Midomafetamine may decrease the sedative activities of Emedastine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Emedastine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Emedastine.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Emedastine.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Emedastine.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Emedastine.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Emedastine.
Metamfetamine Metamfetamine may decrease the sedative activities of Emedastine.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Emedastine.
Ritobegron Ritobegron may decrease the sedative activities of Emedastine.
Mephedrone Mephedrone may decrease the sedative activities of Emedastine.
Methoxyphenamine Methoxyphenamine may decrease the sedative activities of Emedastine.
Gepefrine Gepefrine may decrease the sedative activities of Emedastine.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Emedastine.
Phendimetrazine Phendimetrazine may decrease the sedative activities of Emedastine.
Dofetilide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Dofetilide.
Citalopram The risk or severity of QTc prolongation can be increased when Emedastine is combined with Citalopram.
Anagrelide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Anagrelide.
Disopyramide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Disopyramide.
Clemastine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Clemastine.
Ibutilide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Ibutilide.
Valproic acid The risk or severity of QTc prolongation can be increased when Emedastine is combined with Valproic acid.
Terfenadine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Terfenadine.
Grepafloxacin The risk or severity of QTc prolongation can be increased when Emedastine is combined with Grepafloxacin.
Quinine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Quinine.
Sotalol The risk or severity of QTc prolongation can be increased when Emedastine is combined with Sotalol.
Erlotinib The risk or severity of QTc prolongation can be increased when Emedastine is combined with Erlotinib.
Toremifene The risk or severity of QTc prolongation can be increased when Emedastine is combined with Toremifene.
Cisapride The risk or severity of QTc prolongation can be increased when Emedastine is combined with Cisapride.
Imatinib The risk or severity of QTc prolongation can be increased when Emedastine is combined with Imatinib.
Astemizole The risk or severity of QTc prolongation can be increased when Emedastine is combined with Astemizole.
Thioridazine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Thioridazine.
Trovafloxacin The risk or severity of QTc prolongation can be increased when Emedastine is combined with Trovafloxacin.
Mifepristone The risk or severity of QTc prolongation can be increased when Emedastine is combined with Mifepristone.
Flupentixol The risk or severity of QTc prolongation can be increased when Emedastine is combined with Flupentixol.
Cocaine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Cocaine.
Quinidine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Quinidine.
Procainamide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Procainamide.
Pimozide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Pimozide.
Amiodarone The risk or severity of QTc prolongation can be increased when Emedastine is combined with Amiodarone.
Arsenic trioxide The risk or severity of QTc prolongation can be increased when Emedastine is combined with Arsenic trioxide.
Escitalopram The risk or severity of QTc prolongation can be increased when Emedastine is combined with Escitalopram.
Domperidone The risk or severity of QTc prolongation can be increased when Emedastine is combined with Domperidone.
Sparfloxacin The risk or severity of QTc prolongation can be increased when Emedastine is combined with Sparfloxacin.
Halofantrine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Halofantrine.
Bepridil The risk or severity of QTc prolongation can be increased when Emedastine is combined with Bepridil.
Paliperidone The risk or severity of QTc prolongation can be increased when Emedastine is combined with Paliperidone.
Lithium cation The risk or severity of QTc prolongation can be increased when Emedastine is combined with Lithium cation.
Temafloxacin The risk or severity of QTc prolongation can be increased when Emedastine is combined with Temafloxacin.
Zuclopenthixol The risk or severity of QTc prolongation can be increased when Emedastine is combined with Zuclopenthixol.
Tetrabenazine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Tetrabenazine.
Dronedarone The risk or severity of QTc prolongation can be increased when Emedastine is combined with Dronedarone.
Nilotinib The risk or severity of QTc prolongation can be increased when Emedastine is combined with Nilotinib.
Iloperidone The risk or severity of QTc prolongation can be increased when Emedastine is combined with Iloperidone.
Vandetanib The risk or severity of QTc prolongation can be increased when Emedastine is combined with Vandetanib.
Romidepsin The risk or severity of QTc prolongation can be increased when Emedastine is combined with Romidepsin.
Asenapine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Asenapine.
Artemether The risk or severity of QTc prolongation can be increased when Emedastine is combined with Artemether.
Lumefantrine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Lumefantrine.
Vemurafenib The risk or severity of QTc prolongation can be increased when Emedastine is combined with Vemurafenib.
Eliglustat The risk or severity of QTc prolongation can be increased when Emedastine is combined with Eliglustat.
Ribociclib The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Emedastine.
Glasdegib The risk or severity of QTc prolongation can be increased when Emedastine is combined with Glasdegib.
Deutetrabenazine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Deutetrabenazine.
Macimorelin The risk or severity of QTc prolongation can be increased when Emedastine is combined with Macimorelin.
Terodiline The risk or severity of QTc prolongation can be increased when Emedastine is combined with Terodiline.
Leuprolide The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Emedastine.
Goserelin The risk or severity of QTc prolongation can be increased when Goserelin is combined with Emedastine.
Erythromycin The risk or severity of QTc prolongation can be increased when Erythromycin is combined with Emedastine.
Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Emedastine.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Emedastine.
Ranolazine The risk or severity of QTc prolongation can be increased when Ranolazine is combined with Emedastine.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Sulfisoxazole is combined with Emedastine.
Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Emedastine.
Methadone The risk or severity of QTc prolongation can be increased when Methadone is combined with Emedastine.
Diltiazem The risk or severity of QTc prolongation can be increased when Diltiazem is combined with Emedastine.
Clozapine The risk or severity of QTc prolongation can be increased when Emedastine is combined with Clozapine.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Emedastine.
Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Emedastine.
Promazine The risk or severity of QTc prolongation can be increased when Promazine is combined with Emedastine.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Emedastine.
Droperidol The risk or severity of QTc prolongation can be increased when Droperidol is combined with Emedastine.
Imipramine The risk or severity of QTc prolongation can be increased when Imipramine is combined with Emedastine.
Chlorpromazine The risk or severity of QTc prolongation can be increased when Chlorpromazine is combined with Emedastine.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Emedastine.
Ciprofloxacin The risk or severity of QTc prolongation can be increased when Ciprofloxacin is combined with Emedastine.

Target Protein

Histamine H1 receptor HRH1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 6 • International brands: 0
Produk
  • Emadine
    Solution / drops • 0.5 mg/1mL • Ophthalmic • US • Approved
  • Emadine
    Liquid • 0.05 % • Ophthalmic • Canada • Approved
  • Emadine
    Solution / drops • 0.5 mg/ml • Ophthalmic • EU • Approved
  • Emadine
    Solution / drops • 0.5 mg/ml • Ophthalmic • EU • Approved
  • Emadine
    Solution / drops • 0.5 mg/ml • Ophthalmic • EU • Approved
  • Emadine
    Solution / drops • 0.5 mg/ml • Ophthalmic • EU • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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