Peringatan Keamanan

Oral LD50 rat: 2150 mg/kg; Oral LD50 Mouse: 2641 mg/kg. Short term adverse effects include nausea, transient dizziness, hypoglycaemia in diabetic patients, and torsade de pointes (rare).

Perhexiline

DB01074

small molecule approved investigational

Deskripsi

Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.

Struktur Molekul 2D

Berat 277.4879
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Variable and non-linear. Some reports show a half-life of 2-6 days, others indicate it could be as high as 30 days.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed (>80%) from the gastrointestinal tract following oral administration.

Metabolisme

The principal metabolites of perhexiline in man are monohydroxyperhexiline (which is excreted, in part, conjugated with glucuronic acid) and dihydroxyperhexiline that accounts for a relatively small proportion of the total metabolites. Two unidentified metabolites have also been found in the faeces. The pharmacological activity of the metabolites is not known. Hydroxylation of perhexiline is controlled by cytochrome P450 2D6 (CY P450 2D6).

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1194 Data
Ceritinib Perhexiline may increase the bradycardic activities of Ceritinib.
Ivabradine Perhexiline may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Perhexiline.
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Perhexiline.
Eliglustat The metabolism of Perhexiline can be decreased when combined with Eliglustat.
Cimetidine The serum concentration of Perhexiline can be increased when it is combined with Cimetidine.
Clopidogrel The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Perhexiline.
Efavirenz The serum concentration of Perhexiline can be decreased when it is combined with Efavirenz.
Melatonin The therapeutic efficacy of Perhexiline can be decreased when used in combination with Melatonin.
Nafcillin The therapeutic efficacy of Perhexiline can be decreased when used in combination with Nafcillin.
Nitroprusside Perhexiline may increase the hypotensive activities of Nitroprusside.
Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Perhexiline.
Lithium citrate The risk or severity of adverse effects can be increased when Perhexiline is combined with Lithium citrate.
Lithium carbonate The risk or severity of adverse effects can be increased when Perhexiline is combined with Lithium carbonate.
Lithium hydroxide The risk or severity of adverse effects can be increased when Perhexiline is combined with Lithium hydroxide.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Perhexiline.
Mirabegron The serum concentration of Perhexiline can be increased when it is combined with Mirabegron.
Boceprevir The serum concentration of Perhexiline can be increased when it is combined with Boceprevir.
Tocainide Tocainide may increase the arrhythmogenic activities of Perhexiline.
Carteolol Perhexiline may increase the arrhythmogenic activities of Carteolol.
Metipranolol Perhexiline may increase the arrhythmogenic activities of Metipranolol.
Xylometazoline Perhexiline may increase the arrhythmogenic activities of Xylometazoline.
Fasudil Perhexiline may increase the arrhythmogenic activities of Fasudil.
Tropisetron Perhexiline may increase the arrhythmogenic activities of Tropisetron.
Spiradoline Perhexiline may increase the arrhythmogenic activities of Spiradoline.
Tiracizine Perhexiline may increase the arrhythmogenic activities of Tiracizine.
Ethacizine Perhexiline may increase the arrhythmogenic activities of Ethacizine.
Hydroquinine Perhexiline may increase the arrhythmogenic activities of Hydroquinine.
Bioallethrin Perhexiline may increase the arrhythmogenic activities of Bioallethrin.
Fosfructose Perhexiline may increase the arrhythmogenic activities of Fosfructose.
Hydroquinidine Perhexiline may increase the arrhythmogenic activities of Hydroquinidine.
SOR-C13 Perhexiline may increase the arrhythmogenic activities of SOR-C13.
Acetyldigitoxin Acetyldigitoxin may increase the arrhythmogenic activities of Perhexiline.
Deslanoside Perhexiline may increase the arrhythmogenic activities of Deslanoside.
Cymarin Perhexiline may increase the arrhythmogenic activities of Cymarin.
Metildigoxin Perhexiline may increase the arrhythmogenic activities of Metildigoxin.
Acetyldigoxin Perhexiline may increase the arrhythmogenic activities of Acetyldigoxin.
Nimodipine Nimodipine may increase the arrhythmogenic activities of Perhexiline.
Atropine Atropine may increase the arrhythmogenic activities of Perhexiline.
Adenosine Adenosine may increase the arrhythmogenic activities of Perhexiline.
Levosimendan Levosimendan may increase the arrhythmogenic activities of Perhexiline.
Prenylamine Perhexiline may increase the arrhythmogenic activities of Prenylamine.
Fluspirilene Perhexiline may increase the arrhythmogenic activities of Fluspirilene.
Azimilide Perhexiline may increase the arrhythmogenic activities of Azimilide.
Tedisamil Perhexiline may increase the arrhythmogenic activities of Tedisamil.
Nilvadipine Perhexiline may increase the arrhythmogenic activities of Nilvadipine.
Fendiline Perhexiline may increase the arrhythmogenic activities of Fendiline.
Eperisone Perhexiline may increase the arrhythmogenic activities of Eperisone.
Melperone Perhexiline may increase the arrhythmogenic activities of Melperone.
Benidipine Perhexiline may increase the arrhythmogenic activities of Benidipine.
Simendan Perhexiline may increase the arrhythmogenic activities of Simendan.
Otilonium Perhexiline may increase the arrhythmogenic activities of Otilonium.
Nizofenone Perhexiline may increase the arrhythmogenic activities of Nizofenone.
Bunaftine Perhexiline may increase the arrhythmogenic activities of Bunaftine.
Lorcainide Perhexiline may increase the arrhythmogenic activities of Lorcainide.
Penfluridol Perhexiline may increase the arrhythmogenic activities of Penfluridol.
Dexverapamil Perhexiline may increase the arrhythmogenic activities of Dexverapamil.
Disopyramide Disopyramide may increase the arrhythmogenic activities of Perhexiline.
Ibutilide Ibutilide may increase the arrhythmogenic activities of Perhexiline.
Terodiline Perhexiline may increase the arrhythmogenic activities of Terodiline.
Isradipine Isradipine may increase the arrhythmogenic activities of Perhexiline.
Trimethadione Trimethadione may increase the arrhythmogenic activities of Perhexiline.
Digoxin Digoxin may increase the arrhythmogenic activities of Perhexiline.
Lamotrigine Lamotrigine may increase the arrhythmogenic activities of Perhexiline.
Verapamil Verapamil may increase the arrhythmogenic activities of Perhexiline.
Losartan Losartan may increase the arrhythmogenic activities of Perhexiline.
Levomenthol Levomenthol may increase the arrhythmogenic activities of Perhexiline.
Zonisamide Zonisamide may increase the arrhythmogenic activities of Perhexiline.
Nitrendipine Nitrendipine may increase the arrhythmogenic activities of Perhexiline.
Nimesulide Perhexiline may increase the arrhythmogenic activities of Nimesulide.
Cyclandelate Perhexiline may increase the arrhythmogenic activities of Cyclandelate.
Methsuximide Perhexiline may increase the arrhythmogenic activities of Methsuximide.
Seletracetam Perhexiline may increase the arrhythmogenic activities of Seletracetam.
Nylidrin Perhexiline may increase the arrhythmogenic activities of Nylidrin.
Ziconotide Perhexiline may increase the arrhythmogenic activities of Ziconotide.
Dotarizine Perhexiline may increase the arrhythmogenic activities of Dotarizine.
Tranilast Perhexiline may increase the arrhythmogenic activities of Tranilast.
Agmatine Perhexiline may increase the arrhythmogenic activities of Agmatine.
Trimebutine Perhexiline may increase the arrhythmogenic activities of Trimebutine.
Pinaverium Perhexiline may increase the arrhythmogenic activities of Pinaverium.
Nicorandil Perhexiline may increase the arrhythmogenic activities of Nicorandil.
Barnidipine Perhexiline may increase the arrhythmogenic activities of Barnidipine.
Aranidipine Perhexiline may increase the arrhythmogenic activities of Aranidipine.
Azelnidipine Perhexiline may increase the arrhythmogenic activities of Azelnidipine.
Cilnidipine Perhexiline may increase the arrhythmogenic activities of Cilnidipine.
Darodipine Perhexiline may increase the arrhythmogenic activities of Darodipine.
Efonidipine Perhexiline may increase the arrhythmogenic activities of Efonidipine.
Lacidipine Perhexiline may increase the arrhythmogenic activities of Lacidipine.
Niguldipine Perhexiline may increase the arrhythmogenic activities of Niguldipine.
Niludipine Perhexiline may increase the arrhythmogenic activities of Niludipine.
Carboxyamidotriazole Perhexiline may increase the arrhythmogenic activities of Carboxyamidotriazole.
Naftopidil Perhexiline may increase the arrhythmogenic activities of Naftopidil.
Tetrahydropalmatine Perhexiline may increase the arrhythmogenic activities of Tetrahydropalmatine.
Vinpocetine Perhexiline may increase the arrhythmogenic activities of Vinpocetine.
Gallopamil Perhexiline may increase the arrhythmogenic activities of Gallopamil.
Bencyclane Perhexiline may increase the arrhythmogenic activities of Bencyclane.
Lidoflazine Perhexiline may increase the arrhythmogenic activities of Lidoflazine.
Caroverine Perhexiline may increase the arrhythmogenic activities of Caroverine.
WIN 55212-2 Perhexiline may increase the arrhythmogenic activities of WIN 55212-2.
Fish oil Perhexiline may increase the arrhythmogenic activities of Fish oil.

Target Protein

Carnitine O-palmitoyltransferase 1, liver isoform CPT1A
Carnitine O-palmitoyltransferase 1, muscle isoform CPT1B
Carnitine O-palmitoyltransferase 2, mitochondrial CPT2
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2

Referensi & Sumber

Synthesis reference: Stephen W. Horgan, Frank P. Palopoli, Edward J. Schwoegler, "Process for preparing 2-(2,2-dicyclohexylethyl)piperidine." U.S. Patent US4069222, issued August, 1950.

Contoh Produk & Brand

Produk: 0 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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