Mequitazine

DB01071

small molecule experimental

Deskripsi

Mequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Struktur Molekul 2D

Berat 322.467
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

812 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Mequitazine.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Mequitazine.
Erythromycin The risk or severity of ventricular arrhythmias and torsade de pointes can be increased when Erythromycin is combined with Mequitazine.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Mequitazine.
Colchicine The metabolism of Colchicine can be decreased when combined with Mequitazine.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Mequitazine.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Mequitazine.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Mequitazine.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Mequitazine.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Mequitazine.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Mequitazine.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Mequitazine.
Benzylpenicilloyl polylysine Mequitazine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Mequitazine.
Reserpine Reserpine may increase the arrhythmogenic activities of Mequitazine.
Olanzapine Olanzapine may increase the arrhythmogenic activities of Mequitazine.
Clozapine The serum concentration of Clozapine can be increased when it is combined with Mequitazine.
Thiethylperazine Thiethylperazine may increase the arrhythmogenic activities of Mequitazine.
Sulpiride Sulpiride may increase the arrhythmogenic activities of Mequitazine.
Loxapine Loxapine may increase the arrhythmogenic activities of Mequitazine.
Remoxipride Remoxipride may increase the arrhythmogenic activities of Mequitazine.
Promazine Promazine may increase the arrhythmogenic activities of Mequitazine.
Prochlorperazine Prochlorperazine may increase the arrhythmogenic activities of Mequitazine.
Droperidol Droperidol may increase the arrhythmogenic activities of Mequitazine.
Chlorpromazine Chlorpromazine may increase the arrhythmogenic activities of Mequitazine.
Triflupromazine Triflupromazine may increase the arrhythmogenic activities of Mequitazine.
Amoxapine Amoxapine may increase the arrhythmogenic activities of Mequitazine.
Fluphenazine Fluphenazine may increase the arrhythmogenic activities of Mequitazine.
Thioridazine Thioridazine may increase the arrhythmogenic activities of Mequitazine.
Moricizine Moricizine may increase the arrhythmogenic activities of Mequitazine.
Risperidone Risperidone may increase the arrhythmogenic activities of Mequitazine.
Trifluoperazine Trifluoperazine may increase the arrhythmogenic activities of Mequitazine.
Perphenazine Perphenazine may increase the arrhythmogenic activities of Mequitazine.
Flupentixol Flupentixol may increase the arrhythmogenic activities of Mequitazine.
Mesoridazine Mesoridazine may increase the arrhythmogenic activities of Mequitazine.
Acetophenazine Acetophenazine may increase the arrhythmogenic activities of Mequitazine.
Promethazine Promethazine may increase the arrhythmogenic activities of Mequitazine.
Pimozide Pimozide may increase the arrhythmogenic activities of Mequitazine.
Quetiapine Quetiapine may increase the arrhythmogenic activities of Mequitazine.
Chlorprothixene Chlorprothixene may increase the arrhythmogenic activities of Mequitazine.
Alimemazine Alimemazine may increase the arrhythmogenic activities of Mequitazine.
Paliperidone Paliperidone may increase the arrhythmogenic activities of Mequitazine.
Lithium cation Lithium cation may increase the arrhythmogenic activities of Mequitazine.
Methotrimeprazine Methotrimeprazine may increase the arrhythmogenic activities of Mequitazine.
Periciazine Periciazine may increase the arrhythmogenic activities of Mequitazine.
Acepromazine Acepromazine may increase the arrhythmogenic activities of Mequitazine.
Aceprometazine Aceprometazine may increase the arrhythmogenic activities of Mequitazine.
Molindone Molindone may increase the arrhythmogenic activities of Mequitazine.
Pipotiazine Pipotiazine may increase the arrhythmogenic activities of Mequitazine.
Thioproperazine Thioproperazine may increase the arrhythmogenic activities of Mequitazine.
Thiothixene Thiothixene may increase the arrhythmogenic activities of Mequitazine.
Zuclopenthixol Zuclopenthixol may increase the arrhythmogenic activities of Mequitazine.
Fluspirilene Fluspirilene may increase the arrhythmogenic activities of Mequitazine.
Osanetant Osanetant may increase the arrhythmogenic activities of Mequitazine.
Bifeprunox Bifeprunox may increase the arrhythmogenic activities of Mequitazine.
BL-1020 BL-1020 may increase the arrhythmogenic activities of Mequitazine.
Cariprazine Cariprazine may increase the arrhythmogenic activities of Mequitazine.
Lumateperone Lumateperone may increase the arrhythmogenic activities of Mequitazine.
Sertindole Sertindole may increase the arrhythmogenic activities of Mequitazine.
Asenapine Asenapine may increase the arrhythmogenic activities of Mequitazine.
Amisulpride Amisulpride may increase the arrhythmogenic activities of Mequitazine.
Lurasidone Lurasidone may increase the arrhythmogenic activities of Mequitazine.
Perospirone Perospirone may increase the arrhythmogenic activities of Mequitazine.
Amperozide Amperozide may increase the arrhythmogenic activities of Mequitazine.
Cyamemazine Cyamemazine may increase the arrhythmogenic activities of Mequitazine.
Brexpiprazole Brexpiprazole may increase the arrhythmogenic activities of Mequitazine.
Blonanserin Blonanserin may increase the arrhythmogenic activities of Mequitazine.
Melperone Melperone may increase the arrhythmogenic activities of Mequitazine.
Zotepine Zotepine may increase the arrhythmogenic activities of Mequitazine.
Brilaroxazine Brilaroxazine may increase the arrhythmogenic activities of Mequitazine.
Pipamperone Pipamperone may increase the arrhythmogenic activities of Mequitazine.
Azaperone Azaperone may increase the arrhythmogenic activities of Mequitazine.
Propiopromazine Propiopromazine may increase the arrhythmogenic activities of Mequitazine.
Tetrahydropalmatine Tetrahydropalmatine may increase the arrhythmogenic activities of Mequitazine.
Ecopipam Ecopipam may increase the arrhythmogenic activities of Mequitazine.
Bromperidol Bromperidol may increase the arrhythmogenic activities of Mequitazine.
Raclopride Raclopride may increase the arrhythmogenic activities of Mequitazine.
Ritanserin Ritanserin may increase the arrhythmogenic activities of Mequitazine.
Perazine Perazine may increase the arrhythmogenic activities of Mequitazine.
Benperidol Benperidol may increase the arrhythmogenic activities of Mequitazine.
Prothipendyl Prothipendyl may increase the arrhythmogenic activities of Mequitazine.
Tiapride Tiapride may increase the arrhythmogenic activities of Mequitazine.
Butaperazine Butaperazine may increase the arrhythmogenic activities of Mequitazine.
Clothiapine Clothiapine may increase the arrhythmogenic activities of Mequitazine.
Sultopride Sultopride may increase the arrhythmogenic activities of Mequitazine.
Chlorproethazine Chlorproethazine may increase the arrhythmogenic activities of Mequitazine.
Oxypertine Oxypertine may increase the arrhythmogenic activities of Mequitazine.
Thiazinam Thiazinam may increase the arrhythmogenic activities of Mequitazine.
Veralipride Veralipride may increase the arrhythmogenic activities of Mequitazine.
Trifluperidol Trifluperidol may increase the arrhythmogenic activities of Mequitazine.
Moperone Moperone may increase the arrhythmogenic activities of Mequitazine.
Thiopropazate Thiopropazate may increase the arrhythmogenic activities of Mequitazine.
Fluanisone Fluanisone may increase the arrhythmogenic activities of Mequitazine.
Mosapramine Mosapramine may increase the arrhythmogenic activities of Mequitazine.
Dixyrazine Dixyrazine may increase the arrhythmogenic activities of Mequitazine.
Penfluridol Penfluridol may increase the arrhythmogenic activities of Mequitazine.
Clopenthixol Clopenthixol may increase the arrhythmogenic activities of Mequitazine.
Perphenazine enanthate Perphenazine enanthate may increase the arrhythmogenic activities of Mequitazine.
Aripiprazole Aripiprazole may increase the arrhythmogenic activities of Mequitazine.
Aripiprazole lauroxil Aripiprazole lauroxil may increase the arrhythmogenic activities of Mequitazine.

Target Protein

Histamine H1 receptor HRH1

Referensi & Sumber

Synthesis reference: Charles Mioskowski, Vanessa Gonnot, Rachid Baati, Marc Nicolas, "NOVEL QUINUCLIDINE DERIVATIVE USEFUL IN THE PREPARATION OF MEQUITAZINE." U.S. Patent US20100105897, issued April 29, 2010.
Artikel (PubMed)
  • PMID: 16568706
    Ramirez Chanona N, del Rio Navarro BE, Perez Martin J: Efficacy of mequitazine (Primalan) on the relief of symptoms of allergic rhinoconjunctivitis in children. Documented clinical experience. Rev Alerg Mex. 2005 Nov-Dec;52(6):221-5.
  • PMID: 14987305
    Theunissen EL, Vermeeren A, van Oers AC, van Maris I, Ramaekers JG: A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo. Clin Exp Allergy. 2004 Feb;34(2):250-8.
  • PMID: 9454781
    Nakamura K, Yokoi T, Kodama T, Inoue K, Nagashima K, Shimada N, Shimizu T, Kamataki T: Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42.
  • PMID: 9188930
    Persi L, Dupin O, Arnaud B, Trinquand C, Michel FB, Bousquet J: Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis. Allergy. 1997 Apr;52(4):451-4.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Kitazemin
  • Metaplexan
  • Mircol
  • Primalan
  • Zesulan

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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