Peringatan Keamanan

Information on cefditoren pivoxil overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. In acute animal toxicity studies, cefditoren pivoxil when tested at the limit oral doses of 5100 mg/kg in rats and up to 2000 mg/kg in dogs did not exhibit any health effects of concern.

Cefditoren

DB01066

small molecule approved investigational

Deskripsi

Cefditoren is an oral third-generation cephalosporin. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.

Struktur Molekul 2D

Berat 506.578
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Mean terminal elimination half-life is 1.6 ± 0.4 hours in young healthy adults.
Volume Distribusi * 9.3 ± 1.6 L
Klirens (Clearance) * renal cl=4-5 L/h [oral administration]

Absorpsi

Following oral administration, cefditoren pivoxil is absorbed from the gastrointestinal tract and hydrolyzed to cefditoren by esterases. Under fasting conditions, the estimated absolute bioavailability of cefditoren pivoxil is approximately 14%. The absolute bioavailability of cefditoren pivoxil administered with a low fat meal (693 cal, 14 g fat, 122 g carb, 23 g protein) is 16.1 ± 3.0%.

Metabolisme

Hydrolysis of cefditoren pivoxil to its active component, cefditoren, results in the formation of pivalate. Cefditoren is not appreciably metabolized.

Rute Eliminasi

Pivalate is mainly eliminated (>99%) through renal excretion, nearly exclusively as pivaloylcarnitine.

Interaksi Makanan

1 Data
  • 1. Avoid multivalent ions. Avoid antacids containing magnesium and aluminum hydroxides when possible, otherwise separate the administration of antacids and this drug by several hours.

Interaksi Obat

829 Data
Cimetidine The serum concentration of Cefditoren can be decreased when it is combined with Cimetidine.
Nizatidine The serum concentration of Cefditoren can be decreased when it is combined with Nizatidine.
Ranitidine The serum concentration of Cefditoren can be decreased when it is combined with Ranitidine.
Famotidine The serum concentration of Cefditoren can be decreased when it is combined with Famotidine.
Methantheline The serum concentration of Cefditoren can be decreased when it is combined with Methantheline.
Magnesium oxide The serum concentration of Cefditoren can be decreased when it is combined with Magnesium oxide.
Sodium bicarbonate The serum concentration of Cefditoren can be decreased when it is combined with Sodium bicarbonate.
Aluminum hydroxide The serum concentration of Cefditoren can be decreased when it is combined with Aluminum hydroxide.
Calcium carbonate The serum concentration of Cefditoren can be decreased when it is combined with Calcium carbonate.
Metiamide The serum concentration of Cefditoren can be decreased when it is combined with Metiamide.
Roxatidine acetate The serum concentration of Cefditoren can be decreased when it is combined with Roxatidine acetate.
Magaldrate The serum concentration of Cefditoren can be decreased when it is combined with Magaldrate.
Magnesium hydroxide The serum concentration of Cefditoren can be decreased when it is combined with Magnesium hydroxide.
Magnesium trisilicate The serum concentration of Cefditoren can be decreased when it is combined with Magnesium trisilicate.
Magnesium carbonate The serum concentration of Cefditoren can be decreased when it is combined with Magnesium carbonate.
Lafutidine The serum concentration of Cefditoren can be decreased when it is combined with Lafutidine.
Lavoltidine The serum concentration of Cefditoren can be decreased when it is combined with Lavoltidine.
Bismuth subnitrate The serum concentration of Cefditoren can be decreased when it is combined with Bismuth subnitrate.
Magnesium silicate The serum concentration of Cefditoren can be decreased when it is combined with Magnesium silicate.
Aluminium acetoacetate The serum concentration of Cefditoren can be decreased when it is combined with Aluminium acetoacetate.
Hydrotalcite The serum concentration of Cefditoren can be decreased when it is combined with Hydrotalcite.
Magnesium peroxide The serum concentration of Cefditoren can be decreased when it is combined with Magnesium peroxide.
Almasilate The serum concentration of Cefditoren can be decreased when it is combined with Almasilate.
Aluminium glycinate The serum concentration of Cefditoren can be decreased when it is combined with Aluminium glycinate.
Aloglutamol The serum concentration of Cefditoren can be decreased when it is combined with Aloglutamol.
Niperotidine The serum concentration of Cefditoren can be decreased when it is combined with Niperotidine.
Calcium silicate The serum concentration of Cefditoren can be decreased when it is combined with Calcium silicate.
Aluminium phosphate The serum concentration of Cefditoren can be decreased when it is combined with Aluminium phosphate.
Pantoprazole The serum concentration of Cefditoren can be decreased when it is combined with Pantoprazole.
Rabeprazole The serum concentration of Cefditoren can be decreased when it is combined with Rabeprazole.
Omeprazole The serum concentration of Cefditoren can be decreased when it is combined with Omeprazole.
Lansoprazole The serum concentration of Cefditoren can be decreased when it is combined with Lansoprazole.
Esomeprazole The serum concentration of Cefditoren can be decreased when it is combined with Esomeprazole.
Dexlansoprazole The serum concentration of Cefditoren can be decreased when it is combined with Dexlansoprazole.
Dexrabeprazole The serum concentration of Cefditoren can be decreased when it is combined with Dexrabeprazole.
Sodium zirconium cyclosilicate The serum concentration of Cefditoren can be decreased when it is combined with Sodium zirconium cyclosilicate.
Vonoprazan The serum concentration of Cefditoren can be decreased when it is combined with Vonoprazan.
Probenecid The serum concentration of Cefditoren can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefditoren.
Tenofovir disoproxil Cefditoren may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefditoren may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefditoren may increase the nephrotoxic activities of Tenofovir.
Olanzapine Olanzapine can cause a decrease in the absorption of Cefditoren resulting in a reduced serum concentration and potentially a decrease in efficacy.
Promethazine Promethazine can cause a decrease in the absorption of Cefditoren resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doxepin Doxepin can cause a decrease in the absorption of Cefditoren resulting in a reduced serum concentration and potentially a decrease in efficacy.
Asenapine Asenapine can cause a decrease in the absorption of Cefditoren resulting in a reduced serum concentration and potentially a decrease in efficacy.
Epinastine Epinastine can cause a decrease in the absorption of Cefditoren resulting in a reduced serum concentration and potentially a decrease in efficacy.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefditoren.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefditoren.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefditoren.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefditoren.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefditoren.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefditoren.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefditoren.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefditoren.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefditoren.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefditoren.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefditoren.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefditoren.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefditoren.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefditoren.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefditoren.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefditoren.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefditoren.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefditoren.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefditoren.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefditoren.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefditoren.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefditoren.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefditoren.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefditoren.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefditoren.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefditoren.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefditoren.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefditoren.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefditoren.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefditoren.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefditoren.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefditoren.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefditoren is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefditoren.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefditoren.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefditoren.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefditoren.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefditoren.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefditoren.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefditoren.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefditoren.
Atazanavir The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Atazanavir.
Colistimethate The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Colistimethate.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefuroxime.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefapirin.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefprozil.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Lumiracoxib.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefamandole.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefazolin.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefonicid.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefoperazone.

Target Protein

Penicillin-binding protein 2B penA
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Kiyoshi Yasui, Masahiro Onodera, Masamichi Sukegawa, Tatsuo Watanabe, Yuichi Yamamoto, Yasushi Murai, Katsuharu Iinuma, "Crystalline substance of cefditoren pivoxyl and the production of the same." U.S. Patent US6294669, issued March, 1986.
Artikel (PubMed)
  • PMID: 20566418
    Tempera G, Furneri PM, Carlone NA, Cocuzza C, Rigoli R, Musumeci R, Pilloni AP, Prenna M, Tufano MA, Tullio V, Vitali LA, Nicoletti G: Antibiotic susceptibility of respiratory pathogens recently isolated in Italy: focus on cefditoren. J Chemother. 2010 Jun;22(3):153-9.

Contoh Produk & Brand

Produk: 8 • International brands: 1
Produk
  • Cefditoren Pivoxil
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Cefditoren Pivoxil
    Tablet, film coated • 400 mg/1 • Oral • US • Approved
  • Cefditoren Pivoxil
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Cefditoren Pivoxil
    Tablet, film coated • 400 mg/1 • Oral • US • Approved
  • Spectracef
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Spectracef
    Tablet, film coated • 400 mg/1 • Oral • US • Approved
  • Spectracef
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Spectracef
    Tablet, film coated • 400 mg/1 • Oral • US • Approved
International Brands
  • Meiact

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul