Acetophenazine

DB01063

small molecule approved

Deskripsi

Acetophenazine is an antipsychotic drug of moderate-potency. It is used in the treatment of disorganized and psychotic thinking. It is also used to help treat false perceptions (e.g. hallucinations or delusions). It primarily targets the dopamine D2 receptor.

Struktur Molekul 2D

Berat 411.56
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

832 Data
Buprenorphine Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Hydrocodone Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Magnesium sulfate The therapeutic efficacy of Acetophenazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Mirtazapine Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Orphenadrine Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Rotigotine Acetophenazine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Acetophenazine.
Sodium oxybate Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Thalidomide Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Amisulpride Acetophenazine may increase the antipsychotic activities of Amisulpride.
Methylphenidate The risk or severity of adverse effects can be increased when Acetophenazine is combined with Methylphenidate.
Dexmethylphenidate The risk or severity of adverse effects can be increased when Acetophenazine is combined with Dexmethylphenidate.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Acetophenazine.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with Acetophenazine.
Sulpiride Acetophenazine may increase the antipsychotic activities of Sulpiride.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Acetophenazine.
Lithium citrate Lithium citrate may increase the neurotoxic activities of Acetophenazine.
Lithium hydroxide Lithium hydroxide may increase the neurotoxic activities of Acetophenazine.
Mequitazine Acetophenazine may increase the arrhythmogenic activities of Mequitazine.
Thiopental The risk or severity of adverse effects can be increased when Acetophenazine is combined with Thiopental.
Metyrosine The risk or severity of extrapyramidal symptoms and CNS depression can be increased when Metyrosine is combined with Acetophenazine.
Ethanol Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Fluvoxamine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Acetophenazine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Acetophenazine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Acetophenazine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Acetophenazine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Acetophenazine is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Acetophenazine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Seproxetine.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Acetophenazine.
Indalpine The risk or severity of adverse effects can be increased when Acetophenazine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Acetophenazine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Acetophenazine is combined with Alaproclate.
Esmolol The serum concentration of Esmolol can be increased when it is combined with Acetophenazine.
Betaxolol The serum concentration of Betaxolol can be increased when it is combined with Acetophenazine.
Metoprolol The serum concentration of Metoprolol can be increased when it is combined with Acetophenazine.
Atenolol The serum concentration of Atenolol can be increased when it is combined with Acetophenazine.
Timolol The serum concentration of Timolol can be increased when it is combined with Acetophenazine.
Sotalol The serum concentration of Sotalol can be increased when it is combined with Acetophenazine.
Propranolol The serum concentration of Propranolol can be increased when it is combined with Acetophenazine.
Labetalol The serum concentration of Labetalol can be increased when it is combined with Acetophenazine.
Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Acetophenazine.
Alprenolol The serum concentration of Alprenolol can be increased when it is combined with Acetophenazine.
Pindolol The serum concentration of Pindolol can be increased when it is combined with Acetophenazine.
Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Acetophenazine.
Propafenone The serum concentration of Propafenone can be increased when it is combined with Acetophenazine.
Acebutolol The serum concentration of Acebutolol can be increased when it is combined with Acetophenazine.
Nadolol The serum concentration of Nadolol can be increased when it is combined with Acetophenazine.
Bevantolol The serum concentration of Bevantolol can be increased when it is combined with Acetophenazine.
Practolol The serum concentration of Practolol can be increased when it is combined with Acetophenazine.
Penbutolol The serum concentration of Penbutolol can be increased when it is combined with Acetophenazine.
Oxprenolol The serum concentration of Oxprenolol can be increased when it is combined with Acetophenazine.
Dexpropranolol The serum concentration of Dexpropranolol can be increased when it is combined with Acetophenazine.
Celiprolol The serum concentration of Celiprolol can be increased when it is combined with Acetophenazine.
Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Acetophenazine.
Bufuralol The serum concentration of Bufuralol can be increased when it is combined with Acetophenazine.
Bopindolol The serum concentration of Bopindolol can be increased when it is combined with Acetophenazine.
Bupranolol The serum concentration of Bupranolol can be increased when it is combined with Acetophenazine.
Indenolol The serum concentration of Indenolol can be increased when it is combined with Acetophenazine.
Arotinolol The serum concentration of Arotinolol can be increased when it is combined with Acetophenazine.
Levobetaxolol The serum concentration of Levobetaxolol can be increased when it is combined with Acetophenazine.
Talinolol The serum concentration of Talinolol can be increased when it is combined with Acetophenazine.
Anisodamine The serum concentration of Anisodamine can be increased when it is combined with Acetophenazine.
Bucindolol The serum concentration of Bucindolol can be increased when it is combined with Acetophenazine.
Esatenolol The serum concentration of Esatenolol can be increased when it is combined with Acetophenazine.
Cloranolol The serum concentration of Cloranolol can be increased when it is combined with Acetophenazine.
Mepindolol The serum concentration of Mepindolol can be increased when it is combined with Acetophenazine.
Epanolol The serum concentration of Epanolol can be increased when it is combined with Acetophenazine.
Tertatolol The serum concentration of Tertatolol can be increased when it is combined with Acetophenazine.
Landiolol The serum concentration of Landiolol can be increased when it is combined with Acetophenazine.
Morphine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Morphine.
Codeine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Codeine.
Hydromorphone The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Hydromorphone.
Meperidine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Meperidine.
Oxycodone The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Oxycodone.
Butorphanol The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Butorphanol.
Dextropropoxyphene The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Dextropropoxyphene.
Pentazocine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Pentazocine.
Naltrexone The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Naltrexone.

Target Protein

D(2) dopamine receptor DRD2
Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 702341
    Jones GL, Woodbury DM: Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. J Pharmacol Exp Ther. 1978 Oct;207(1):203-11.
  • PMID: 6147851
    Tam SW, Cook L: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-3H SKF 10,047 and 3Hhaloperidol binding in guinea pig brain membranes. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Tindal — Schering

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