Norfloxacin

DB01059

small molecule approved

Deskripsi

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.

Struktur Molekul 2D

Berat 319.3308
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3-4 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapid

Metabolisme

Via liver and kidney

Rute Eliminasi

Norfloxacin is eliminated through metabolism, biliary excretion, and renal excretion. It is expected to undergo both glomerular filtration and tubular secretion during renal excretion, as shown by its high renal clearance rate of approximately 275 mL/min.

Interaksi Makanan

3 Data
  • 1. Drink plenty of fluids.
  • 2. Limit caffeine intake.
  • 3. Take on an empty stomach.

Interaksi Obat

1052 Data
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Norfloxacin.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Norfloxacin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Norfloxacin.
Didanosine Didanosine can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Probenecid Probenecid may decrease the excretion rate of Norfloxacin which could result in a higher serum level.
Quinapril Quinapril can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate Calcium acetate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Calcium can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric carboxymaltose Ferric carboxymaltose can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium citrate Calcium citrate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium gluconate Calcium gluconate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium polycarbophil Calcium polycarbophil can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Norfloxacin.
Colchicine The metabolism of Colchicine can be decreased when combined with Norfloxacin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Norfloxacin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Norfloxacin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Norfloxacin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Norfloxacin.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Norfloxacin.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Norfloxacin.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Norfloxacin.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Norfloxacin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Norfloxacin.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Norfloxacin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Norfloxacin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Norfloxacin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Norfloxacin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Norfloxacin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Norfloxacin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Norfloxacin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Norfloxacin.
Nitrofurantoin The therapeutic efficacy of Norfloxacin can be decreased when used in combination with Nitrofurantoin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Norfloxacin.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Norfloxacin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Norfloxacin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Norfloxacin.
Insulin human The therapeutic efficacy of Insulin human can be increased when used in combination with Norfloxacin.
Insulin lispro The therapeutic efficacy of Insulin lispro can be increased when used in combination with Norfloxacin.
Insulin pork The therapeutic efficacy of Insulin pork can be increased when used in combination with Norfloxacin.
Troglitazone The therapeutic efficacy of Troglitazone can be increased when used in combination with Norfloxacin.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Norfloxacin.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Norfloxacin.
Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Norfloxacin.
Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Norfloxacin.
Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Norfloxacin.
Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Norfloxacin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Norfloxacin.
Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Norfloxacin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Norfloxacin.
Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Norfloxacin.
Pentamidine The therapeutic efficacy of Pentamidine can be increased when used in combination with Norfloxacin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Norfloxacin.
Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Norfloxacin.
Phenformin The therapeutic efficacy of Phenformin can be increased when used in combination with Norfloxacin.
Sulfamethoxazole The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Norfloxacin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Norfloxacin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Norfloxacin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Norfloxacin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Norfloxacin.
Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Norfloxacin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Norfloxacin.
Mitiglinide The therapeutic efficacy of Mitiglinide can be increased when used in combination with Norfloxacin.
Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Norfloxacin.
Exenatide The therapeutic efficacy of Exenatide can be increased when used in combination with Norfloxacin.
Mecasermin The therapeutic efficacy of Mecasermin can be increased when used in combination with Norfloxacin.
Pramlintide The therapeutic efficacy of Pramlintide can be increased when used in combination with Norfloxacin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Norfloxacin.
Insulin aspart The therapeutic efficacy of Insulin aspart can be increased when used in combination with Norfloxacin.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Norfloxacin.
Glymidine The therapeutic efficacy of Glymidine can be increased when used in combination with Norfloxacin.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Norfloxacin.
Buformin The therapeutic efficacy of Buformin can be increased when used in combination with Norfloxacin.
Vildagliptin The therapeutic efficacy of Vildagliptin can be increased when used in combination with Norfloxacin.
Voglibose The therapeutic efficacy of Voglibose can be increased when used in combination with Norfloxacin.
NN344 The therapeutic efficacy of NN344 can be increased when used in combination with Norfloxacin.
AMG-222 The therapeutic efficacy of AMG-222 can be increased when used in combination with Norfloxacin.
Bisegliptin The therapeutic efficacy of Bisegliptin can be increased when used in combination with Norfloxacin.
Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Norfloxacin.
Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Norfloxacin.
Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Norfloxacin.
Liraglutide The therapeutic efficacy of Liraglutide can be increased when used in combination with Norfloxacin.
Gosogliptin The therapeutic efficacy of Gosogliptin can be increased when used in combination with Norfloxacin.
Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Norfloxacin.
Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Norfloxacin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Norfloxacin.
Benfluorex The therapeutic efficacy of Benfluorex can be increased when used in combination with Norfloxacin.
Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Norfloxacin.
Albiglutide The therapeutic efficacy of Albiglutide can be increased when used in combination with Norfloxacin.

Target Protein

DNA gyrase subunit A gyrA
DNA gyrase subunit B gyrB
DNA topoisomerase 4 subunit A parC
DNA topoisomerase 2-alpha TOP2A
DNA gyrase subunit A gyrA
DNA topoisomerase 2 TOP2A
DNA topoisomerase 4 subunit A parC

Referensi & Sumber

Artikel (PubMed)
  • PMID: 3111257
    Goldstein EJ: Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity. Am J Med. 1987 Jun 26;82(6B):3-17.

Contoh Produk & Brand

Produk: 15 • International brands: 1
Produk
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Menampilkan 8 dari 15 produk.
International Brands
  • Chibroxin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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