The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Tizanidine | The serum concentration of Tizanidine can be increased when it is combined with Tocainide. |
| Deferasirox | The serum concentration of Tocainide can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Tocainide can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Tocainide can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Tocainide can be decreased when it is combined with Teriflunomide. |
| Zolmitriptan | The metabolism of Zolmitriptan can be decreased when combined with Tocainide. |
| Abiraterone | The serum concentration of Tocainide can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Tocainide can be increased when combined with Cyproterone acetate. |
| Esmolol | Esmolol may increase the arrhythmogenic activities of Tocainide. |
| Dofetilide | Dofetilide may increase the arrhythmogenic activities of Tocainide. |
| Metoprolol | Metoprolol may increase the arrhythmogenic activities of Tocainide. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Tocainide. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Tocainide. |
| Atenolol | Atenolol may increase the arrhythmogenic activities of Tocainide. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Tocainide. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Tocainide. |
| Timolol | Timolol may increase the arrhythmogenic activities of Tocainide. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Tocainide. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Tocainide. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Tocainide. |
| Nisoldipine | Nisoldipine may increase the arrhythmogenic activities of Tocainide. |
| Hyoscyamine | Hyoscyamine may increase the arrhythmogenic activities of Tocainide. |
| Sotalol | Sotalol may increase the arrhythmogenic activities of Tocainide. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Tocainide. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Tocainide. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Tocainide. |
| Atropine | Atropine may increase the arrhythmogenic activities of Tocainide. |
| Ethosuximide | Ethosuximide may increase the arrhythmogenic activities of Tocainide. |
| Nicardipine | Nicardipine may increase the arrhythmogenic activities of Tocainide. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Tocainide. |
| Magnesium sulfate | Magnesium sulfate may increase the arrhythmogenic activities of Tocainide. |
| Losartan | Losartan may increase the arrhythmogenic activities of Tocainide. |
| Moricizine | Moricizine may increase the arrhythmogenic activities of Tocainide. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Tocainide. |
| Loperamide | Loperamide may increase the arrhythmogenic activities of Tocainide. |
| Alprenolol | Alprenolol may increase the arrhythmogenic activities of Tocainide. |
| Zonisamide | Zonisamide may increase the arrhythmogenic activities of Tocainide. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Tocainide. |
| Felodipine | Felodipine may increase the arrhythmogenic activities of Tocainide. |
| Procainamide | Procainamide may increase the arrhythmogenic activities of Tocainide. |
| Nitrendipine | Nitrendipine may increase the arrhythmogenic activities of Tocainide. |
| Carteolol | Tocainide may increase the arrhythmogenic activities of Carteolol. |
| Perhexiline | Tocainide may increase the arrhythmogenic activities of Perhexiline. |
| Deslanoside | Tocainide may increase the arrhythmogenic activities of Deslanoside. |
| Bretylium | Tocainide may increase the arrhythmogenic activities of Bretylium. |
| Acebutolol | Tocainide may increase the arrhythmogenic activities of Acebutolol. |
| Flecainide | Tocainide may increase the arrhythmogenic activities of Flecainide. |
| Nadolol | Tocainide may increase the arrhythmogenic activities of Nadolol. |
| Metipranolol | Tocainide may increase the arrhythmogenic activities of Metipranolol. |
| Encainide | Tocainide may increase the arrhythmogenic activities of Encainide. |
| Bepridil | Tocainide may increase the arrhythmogenic activities of Bepridil. |
| Practolol | Tocainide may increase the arrhythmogenic activities of Practolol. |
| Digitoxin | Tocainide may increase the arrhythmogenic activities of Digitoxin. |
| Ajmaline | Tocainide may increase the arrhythmogenic activities of Ajmaline. |
| Aprindine | Tocainide may increase the arrhythmogenic activities of Aprindine. |
| Oxprenolol | Tocainide may increase the arrhythmogenic activities of Oxprenolol. |
| Dexpropranolol | Tocainide may increase the arrhythmogenic activities of Dexpropranolol. |
| Nimesulide | Tocainide may increase the arrhythmogenic activities of Nimesulide. |
| Prenylamine | Tocainide may increase the arrhythmogenic activities of Prenylamine. |
| Cyclandelate | Tocainide may increase the arrhythmogenic activities of Cyclandelate. |
| Fluspirilene | Tocainide may increase the arrhythmogenic activities of Fluspirilene. |
| Celiprolol | Tocainide may increase the arrhythmogenic activities of Celiprolol. |
| Dronedarone | Tocainide may increase the arrhythmogenic activities of Dronedarone. |
| Nebivolol | Tocainide may increase the arrhythmogenic activities of Nebivolol. |
| Clevidipine | Tocainide may increase the arrhythmogenic activities of Clevidipine. |
| Azimilide | Tocainide may increase the arrhythmogenic activities of Azimilide. |
| Methsuximide | Tocainide may increase the arrhythmogenic activities of Methsuximide. |
| Seletracetam | Tocainide may increase the arrhythmogenic activities of Seletracetam. |
| Nylidrin | Tocainide may increase the arrhythmogenic activities of Nylidrin. |
| Tedisamil | Tocainide may increase the arrhythmogenic activities of Tedisamil. |
| Vernakalant | Tocainide may increase the arrhythmogenic activities of Vernakalant. |
| Ziconotide | Tocainide may increase the arrhythmogenic activities of Ziconotide. |
| Dotarizine | Tocainide may increase the arrhythmogenic activities of Dotarizine. |
| Cariporide | Tocainide may increase the arrhythmogenic activities of Cariporide. |
| Xylometazoline | Tocainide may increase the arrhythmogenic activities of Xylometazoline. |
| Nilvadipine | Tocainide may increase the arrhythmogenic activities of Nilvadipine. |
| Sparteine | Tocainide may increase the arrhythmogenic activities of Sparteine. |
| Tranilast | Tocainide may increase the arrhythmogenic activities of Tranilast. |
| Fasudil | Tocainide may increase the arrhythmogenic activities of Fasudil. |
| Bupranolol | Tocainide may increase the arrhythmogenic activities of Bupranolol. |
| Agmatine | Tocainide may increase the arrhythmogenic activities of Agmatine. |
| Indenolol | Tocainide may increase the arrhythmogenic activities of Indenolol. |
| Fendiline | Tocainide may increase the arrhythmogenic activities of Fendiline. |
| Eperisone | Tocainide may increase the arrhythmogenic activities of Eperisone. |
| Trimebutine | Tocainide may increase the arrhythmogenic activities of Trimebutine. |
| Pinaverium | Tocainide may increase the arrhythmogenic activities of Pinaverium. |
| Nicorandil | Tocainide may increase the arrhythmogenic activities of Nicorandil. |
| Melperone | Tocainide may increase the arrhythmogenic activities of Melperone. |
| Barnidipine | Tocainide may increase the arrhythmogenic activities of Barnidipine. |
| Aranidipine | Tocainide may increase the arrhythmogenic activities of Aranidipine. |
| Azelnidipine | Tocainide may increase the arrhythmogenic activities of Azelnidipine. |
| Benidipine | Tocainide may increase the arrhythmogenic activities of Benidipine. |
| Cilnidipine | Tocainide may increase the arrhythmogenic activities of Cilnidipine. |
| Darodipine | Tocainide may increase the arrhythmogenic activities of Darodipine. |
| Efonidipine | Tocainide may increase the arrhythmogenic activities of Efonidipine. |
| Lacidipine | Tocainide may increase the arrhythmogenic activities of Lacidipine. |
| Manidipine | Tocainide may increase the arrhythmogenic activities of Manidipine. |
| Niguldipine | Tocainide may increase the arrhythmogenic activities of Niguldipine. |
| Niludipine | Tocainide may increase the arrhythmogenic activities of Niludipine. |
| Tropisetron | Tocainide may increase the arrhythmogenic activities of Tropisetron. |