Oral LD50 in rat is 8900 mg/kg MSDS. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. Neutropenia can occur if high doses are administered consistently for over 2 weeks.
Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms.
Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Methotrexate | The excretion of Methotrexate can be decreased when combined with Benzylpenicillin. |
| Probenecid | The excretion of Benzylpenicillin can be decreased when combined with Probenecid. |
| Doxycycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Doxycycline. |
| Lymecycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Lymecycline. |
| Clomocycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Clomocycline. |
| Tigecycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Tigecycline. |
| Oxytetracycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Oxytetracycline. |
| Demeclocycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Demeclocycline. |
| Tetracycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Tetracycline. |
| Metacycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Metacycline. |
| Minocycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Minocycline. |
| Rolitetracycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Rolitetracycline. |
| Sarecycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Sarecycline. |
| Eravacycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Eravacycline. |
| Omadacycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Omadacycline. |
| Penimepicycline | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Penimepicycline. |
| Aspartame | The excretion of Benzylpenicillin can be decreased when combined with Aspartame. |
| Pravastatin | The excretion of Benzylpenicillin can be decreased when combined with Pravastatin. |
| Pantoprazole | The excretion of Benzylpenicillin can be decreased when combined with Pantoprazole. |
| Cefotiam | The excretion of Benzylpenicillin can be decreased when combined with Cefotiam. |
| Liothyronine | The excretion of Benzylpenicillin can be decreased when combined with Liothyronine. |
| Conjugated estrogens | The excretion of Benzylpenicillin can be decreased when combined with Conjugated estrogens. |
| Indomethacin | The excretion of Benzylpenicillin can be decreased when combined with Indomethacin. |
| Aminohippuric acid | The excretion of Benzylpenicillin can be decreased when combined with Aminohippuric acid. |
| Lansoprazole | The excretion of Benzylpenicillin can be decreased when combined with Lansoprazole. |
| Cefalotin | The excretion of Benzylpenicillin can be decreased when combined with Cefalotin. |
| Tenoxicam | The excretion of Benzylpenicillin can be decreased when combined with Tenoxicam. |
| Cefotaxime | The excretion of Benzylpenicillin can be decreased when combined with Cefotaxime. |
| Zidovudine | The excretion of Benzylpenicillin can be decreased when combined with Zidovudine. |
| Cimetidine | The excretion of Benzylpenicillin can be decreased when combined with Cimetidine. |
| Guanidine | The excretion of Benzylpenicillin can be decreased when combined with Guanidine. |
| Piroxicam | The excretion of Benzylpenicillin can be decreased when combined with Piroxicam. |
| Cephalexin | The excretion of Benzylpenicillin can be decreased when combined with Cephalexin. |
| Enalapril | The excretion of Benzylpenicillin can be decreased when combined with Enalapril. |
| Diclofenac | The excretion of Benzylpenicillin can be decreased when combined with Diclofenac. |
| Leucovorin | The excretion of Benzylpenicillin can be decreased when combined with Leucovorin. |
| Esomeprazole | The excretion of Benzylpenicillin can be decreased when combined with Esomeprazole. |
| Acyclovir | The excretion of Benzylpenicillin can be decreased when combined with Acyclovir. |
| Phenylbutazone | The excretion of Benzylpenicillin can be decreased when combined with Phenylbutazone. |
| Cefaclor | The excretion of Benzylpenicillin can be decreased when combined with Cefaclor. |
| Quinidine | The excretion of Benzylpenicillin can be decreased when combined with Quinidine. |
| Dinoprostone | The excretion of Benzylpenicillin can be decreased when combined with Dinoprostone. |
| Famotidine | The excretion of Benzylpenicillin can be decreased when combined with Famotidine. |
| Salicylic acid | The excretion of Benzylpenicillin can be decreased when combined with Salicylic acid. |
| Acetylsalicylic acid | The excretion of Benzylpenicillin can be decreased when combined with Acetylsalicylic acid. |
| Ganciclovir | The excretion of Benzylpenicillin can be decreased when combined with Ganciclovir. |
| Ketoprofen | The excretion of Benzylpenicillin can be decreased when combined with Ketoprofen. |
| Ibuprofen | The excretion of Benzylpenicillin can be decreased when combined with Ibuprofen. |
| Novobiocin | The excretion of Benzylpenicillin can be decreased when combined with Novobiocin. |
| Succinic acid | The excretion of Succinic acid can be decreased when combined with Benzylpenicillin. |
| Citrulline | The excretion of Citrulline can be decreased when combined with Benzylpenicillin. |
| Oseltamivir | The excretion of Oseltamivir can be decreased when combined with Benzylpenicillin. |
| Tenofovir disoproxil | The excretion of Tenofovir disoproxil can be decreased when combined with Benzylpenicillin. |
| Piperacillin | The excretion of Piperacillin can be decreased when combined with Benzylpenicillin. |
| Trifluridine | The excretion of Trifluridine can be decreased when combined with Benzylpenicillin. |
| Allopurinol | The excretion of Allopurinol can be decreased when combined with Benzylpenicillin. |
| Cefdinir | The excretion of Cefdinir can be decreased when combined with Benzylpenicillin. |
| Valaciclovir | The excretion of Valaciclovir can be decreased when combined with Benzylpenicillin. |
| Levocarnitine | The excretion of Levocarnitine can be decreased when combined with Benzylpenicillin. |
| Fluorescein | The excretion of Fluorescein can be decreased when combined with Benzylpenicillin. |
| Hydrocortisone | The excretion of Hydrocortisone can be decreased when combined with Benzylpenicillin. |
| Ranitidine | The excretion of Ranitidine can be decreased when combined with Benzylpenicillin. |
| Quinapril | The excretion of Quinapril can be decreased when combined with Benzylpenicillin. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Benzylpenicillin. |
| Captopril | The excretion of Captopril can be decreased when combined with Benzylpenicillin. |
| Sitagliptin | The excretion of Sitagliptin can be decreased when combined with Benzylpenicillin. |
| Cefazolin | The excretion of Cefazolin can be decreased when combined with Benzylpenicillin. |
| Ceftizoxime | The excretion of Ceftizoxime can be decreased when combined with Benzylpenicillin. |
| Cefacetrile | The excretion of Cefacetrile can be decreased when combined with Benzylpenicillin. |
| Ceftibuten | The excretion of Ceftibuten can be decreased when combined with Benzylpenicillin. |
| Tazobactam | The excretion of Tazobactam can be decreased when combined with Benzylpenicillin. |
| Cyclic adenosine monophosphate | The excretion of Cyclic adenosine monophosphate can be decreased when combined with Benzylpenicillin. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Benzylpenicillin. |
| Glutaric Acid | The excretion of Glutaric Acid can be decreased when combined with Benzylpenicillin. |
| Oxalic Acid | The excretion of Oxalic Acid can be decreased when combined with Benzylpenicillin. |
| Taurocholic acid | The excretion of Taurocholic acid can be decreased when combined with Benzylpenicillin. |
| Doripenem | The excretion of Doripenem can be decreased when combined with Benzylpenicillin. |
| Saxagliptin | The excretion of Saxagliptin can be decreased when combined with Benzylpenicillin. |
| Ellagic acid | The excretion of Ellagic acid can be decreased when combined with Benzylpenicillin. |
| Cefaloridine | The excretion of Cefaloridine can be decreased when combined with Benzylpenicillin. |
| Avibactam | The excretion of Avibactam can be decreased when combined with Benzylpenicillin. |
| Eluxadoline | The excretion of Eluxadoline can be decreased when combined with Benzylpenicillin. |
| Silibinin | The excretion of Silibinin can be decreased when combined with Benzylpenicillin. |
| Tenofovir alafenamide | The excretion of Tenofovir alafenamide can be decreased when combined with Benzylpenicillin. |
| Baricitinib | The serum concentration of Baricitinib can be increased when it is combined with Benzylpenicillin. |
| Relebactam | The excretion of Relebactam can be decreased when combined with Benzylpenicillin. |
| Tenofovir | The excretion of Tenofovir can be decreased when combined with Benzylpenicillin. |
| Melatonin | The excretion of Benzylpenicillin can be decreased when combined with Melatonin. |
| Ouabain | The excretion of Benzylpenicillin can be decreased when combined with Ouabain. |
| Cefadroxil | The excretion of Benzylpenicillin can be decreased when combined with Cefadroxil. |
| Ceftriaxone | The excretion of Benzylpenicillin can be decreased when combined with Ceftriaxone. |
| Cefamandole | The excretion of Benzylpenicillin can be decreased when combined with Cefamandole. |
| Cefoperazone | The excretion of Benzylpenicillin can be decreased when combined with Cefoperazone. |
| Liotrix | The excretion of Benzylpenicillin can be decreased when combined with Liotrix. |
| Cilastatin | The excretion of Benzylpenicillin can be decreased when combined with Cilastatin. |
| trans-2-hydroxycinnamic acid | The excretion of Benzylpenicillin can be decreased when combined with trans-2-hydroxycinnamic acid. |
| Topiroxostat | The excretion of Benzylpenicillin can be decreased when combined with Topiroxostat. |
| Benzoic acid | The excretion of Benzylpenicillin can be decreased when combined with Benzoic acid. |
| Caprylic acid | The excretion of Benzylpenicillin can be decreased when combined with Caprylic acid. |
| Ataluren | The excretion of Benzylpenicillin can be decreased when combined with Ataluren. |