Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious infections due to susceptible strains of Staphylococcus aureus when other less toxic antibiotics cannot be used. In 2009, the FDA determined novobiocin sodium was withdrawn from sale for reasons of safety or effectiveness.L44062,L43942
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Succinic acid | The excretion of Succinic acid can be decreased when combined with Novobiocin. |
| Citrulline | The excretion of Citrulline can be decreased when combined with Novobiocin. |
| Oseltamivir | The excretion of Oseltamivir can be decreased when combined with Novobiocin. |
| Cefotiam | The excretion of Cefotiam can be decreased when combined with Novobiocin. |
| Tenofovir disoproxil | The excretion of Tenofovir disoproxil can be decreased when combined with Novobiocin. |
| Piperacillin | The excretion of Piperacillin can be decreased when combined with Novobiocin. |
| Indomethacin | The excretion of Indomethacin can be decreased when combined with Novobiocin. |
| Aminohippuric acid | The excretion of Aminohippuric acid can be decreased when combined with Novobiocin. |
| Trifluridine | The excretion of Trifluridine can be decreased when combined with Novobiocin. |
| Cimetidine | The excretion of Cimetidine can be decreased when combined with Novobiocin. |
| Cefdinir | The excretion of Cefdinir can be decreased when combined with Novobiocin. |
| Cephalexin | The excretion of Cephalexin can be decreased when combined with Novobiocin. |
| Valaciclovir | The excretion of Valaciclovir can be decreased when combined with Novobiocin. |
| Levocarnitine | The excretion of Levocarnitine can be decreased when combined with Novobiocin. |
| Leucovorin | The excretion of Leucovorin can be decreased when combined with Novobiocin. |
| Fluorescein | The excretion of Fluorescein can be decreased when combined with Novobiocin. |
| Hydrocortisone | The excretion of Hydrocortisone can be decreased when combined with Novobiocin. |
| Tetracycline | The excretion of Tetracycline can be decreased when combined with Novobiocin. |
| Estradiol | The excretion of Estradiol can be decreased when combined with Novobiocin. |
| Acyclovir | The excretion of Acyclovir can be decreased when combined with Novobiocin. |
| Cefaclor | The excretion of Cefaclor can be decreased when combined with Novobiocin. |
| Ranitidine | The excretion of Ranitidine can be decreased when combined with Novobiocin. |
| Quinapril | The excretion of Quinapril can be decreased when combined with Novobiocin. |
| Bumetanide | The excretion of Bumetanide can be decreased when combined with Novobiocin. |
| Dinoprostone | The excretion of Dinoprostone can be decreased when combined with Novobiocin. |
| Famotidine | The excretion of Famotidine can be decreased when combined with Novobiocin. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Novobiocin. |
| Benzylpenicillin | The excretion of Benzylpenicillin can be decreased when combined with Novobiocin. |
| Captopril | The excretion of Captopril can be decreased when combined with Novobiocin. |
| Sitagliptin | The excretion of Sitagliptin can be decreased when combined with Novobiocin. |
| Cefazolin | The excretion of Cefazolin can be decreased when combined with Novobiocin. |
| Ceftizoxime | The excretion of Ceftizoxime can be decreased when combined with Novobiocin. |
| Cefacetrile | The excretion of Cefacetrile can be decreased when combined with Novobiocin. |
| Ceftibuten | The excretion of Ceftibuten can be decreased when combined with Novobiocin. |
| Tazobactam | The excretion of Tazobactam can be decreased when combined with Novobiocin. |
| Cyclic adenosine monophosphate | The excretion of Cyclic adenosine monophosphate can be decreased when combined with Novobiocin. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Novobiocin. |
| Glutaric Acid | The excretion of Glutaric Acid can be decreased when combined with Novobiocin. |
| Oxalic Acid | The excretion of Oxalic Acid can be decreased when combined with Novobiocin. |
| Taurocholic acid | The excretion of Taurocholic acid can be decreased when combined with Novobiocin. |
| Doripenem | The excretion of Doripenem can be decreased when combined with Novobiocin. |
| Saxagliptin | The excretion of Saxagliptin can be decreased when combined with Novobiocin. |
| Ellagic acid | The excretion of Ellagic acid can be decreased when combined with Novobiocin. |
| Cefaloridine | The excretion of Cefaloridine can be decreased when combined with Novobiocin. |
| Avibactam | The excretion of Avibactam can be decreased when combined with Novobiocin. |
| Silibinin | The excretion of Silibinin can be decreased when combined with Novobiocin. |
| Baricitinib | The serum concentration of Baricitinib can be increased when it is combined with Novobiocin. |
| Relebactam | The excretion of Relebactam can be decreased when combined with Novobiocin. |
| Tenofovir | The excretion of Tenofovir can be decreased when combined with Novobiocin. |
| Hydrochlorothiazide | The excretion of Hydrochlorothiazide can be decreased when combined with Novobiocin. |
| Dexamethasone | The excretion of Dexamethasone can be decreased when combined with Novobiocin. |
| Oxytetracycline | The excretion of Oxytetracycline can be decreased when combined with Novobiocin. |
| Polythiazide | The excretion of Polythiazide can be decreased when combined with Novobiocin. |
| Prednisolone phosphate | The excretion of Prednisolone phosphate can be decreased when combined with Novobiocin. |
| Dexamethasone acetate | The excretion of Dexamethasone acetate can be decreased when combined with Novobiocin. |
| Acamprosate | The excretion of Acamprosate can be decreased when combined with Novobiocin. |
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Novobiocin. |
| Picosulfuric acid | The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Novobiocin. |
| BCG vaccine | The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Novobiocin. |
| Typhoid vaccine | The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Novobiocin. |
| Folic acid | Novobiocin may decrease the excretion rate of Folic acid which could result in a higher serum level. |
| Pravastatin | The excretion of Pravastatin can be decreased when combined with Novobiocin. |
| Conjugated estrogens | The excretion of Conjugated estrogens can be decreased when combined with Novobiocin. |
| Gefitinib | Novobiocin may decrease the excretion rate of Gefitinib which could result in a higher serum level. |
| Allopurinol | The excretion of Allopurinol can be decreased when combined with Novobiocin. |
| Cerivastatin | Novobiocin may decrease the excretion rate of Cerivastatin which could result in a higher serum level. |
| Teniposide | Novobiocin may decrease the excretion rate of Teniposide which could result in a higher serum level. |
| Prazosin | Novobiocin may decrease the excretion rate of Prazosin which could result in a higher serum level. |
| Raloxifene | Novobiocin may decrease the excretion rate of Raloxifene which could result in a higher serum level. |
| Celecoxib | Novobiocin may decrease the excretion rate of Celecoxib which could result in a higher serum level. |
| Zidovudine | The excretion of Zidovudine can be decreased when combined with Novobiocin. |
| Ritonavir | Novobiocin may decrease the excretion rate of Ritonavir which could result in a higher serum level. |
| Oxaliplatin | Novobiocin may decrease the excretion rate of Oxaliplatin which could result in a higher serum level. |
| Vincristine | Novobiocin may decrease the excretion rate of Vincristine which could result in a higher serum level. |
| Fluorouracil | Novobiocin may decrease the excretion rate of Fluorouracil which could result in a higher serum level. |
| Methotrexate | The excretion of Methotrexate can be decreased when combined with Novobiocin. |
| Ivermectin | Novobiocin may decrease the excretion rate of Ivermectin which could result in a higher serum level. |
| Imatinib | Novobiocin may decrease the excretion rate of Imatinib which could result in a higher serum level. |
| Testosterone | Novobiocin may decrease the excretion rate of Testosterone which could result in a higher serum level. |
| Sumatriptan | Novobiocin may decrease the excretion rate of Sumatriptan which could result in a higher serum level. |
| Tamoxifen | Novobiocin may decrease the excretion rate of Tamoxifen which could result in a higher serum level. |
| Mycophenolate mofetil | Novobiocin may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level. |
| Daunorubicin | Novobiocin may decrease the excretion rate of Daunorubicin which could result in a higher serum level. |
| Nitrofurantoin | Novobiocin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. |
| Lamivudine | Novobiocin may decrease the excretion rate of Lamivudine which could result in a higher serum level. |
| Riluzole | Novobiocin may decrease the excretion rate of Riluzole which could result in a higher serum level. |
| Irinotecan | Novobiocin may decrease the excretion rate of Irinotecan which could result in a higher serum level. |
| Etoposide | Novobiocin may decrease the excretion rate of Etoposide which could result in a higher serum level. |
| Sulfasalazine | Novobiocin may decrease the excretion rate of Sulfasalazine which could result in a higher serum level. |
| Dactinomycin | Novobiocin may decrease the excretion rate of Dactinomycin which could result in a higher serum level. |
| Ezetimibe | Novobiocin may decrease the excretion rate of Ezetimibe which could result in a higher serum level. |
| Doxorubicin | Novobiocin may decrease the excretion rate of Doxorubicin which could result in a higher serum level. |
| Topotecan | Novobiocin may decrease the excretion rate of Topotecan which could result in a higher serum level. |
| Tegaserod | Novobiocin may decrease the excretion rate of Tegaserod which could result in a higher serum level. |
| Leflunomide | Novobiocin may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
| Rosuvastatin | The excretion of Rosuvastatin can be decreased when combined with Novobiocin. |
| Mitoxantrone | Novobiocin may decrease the excretion rate of Mitoxantrone which could result in a higher serum level. |
| Dasatinib | Novobiocin may decrease the excretion rate of Dasatinib which could result in a higher serum level. |
| Alvocidib | Novobiocin may decrease the excretion rate of Alvocidib which could result in a higher serum level. |
| Camptothecin | Novobiocin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |