Peringatan Keamanan

Side effects may include acne-like eruptions, burning, dryness, excessive hair growth, infection of the skin, irritation, itching, lack of skin colour, prickly heat, skin inflammation, skin loss or softening, stretch marks.

Fluocinonide

DB01047

small molecule approved investigational

Deskripsi

A topical glucocorticoid used in the treatment of eczema.

Struktur Molekul 2D

Berat 494.5249
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. In general, percutaneous absorption is minimal.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.

Interaksi Obat

1162 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Fluocinonide.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Fluocinonide.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Fluocinonide.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Fluocinonide.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Fluocinonide.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Fluocinonide.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Fluocinonide.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Fluocinonide.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Fluocinonide.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Fluocinonide.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Fluocinonide.
Pegaspargase The serum concentration of Fluocinonide can be increased when it is combined with Pegaspargase.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Fluocinonide.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Fluocinonide.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Fluocinonide.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Fluocinonide.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Fluocinonide.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Fluocinonide.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Fluocinonide.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Fluocinonide.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Fluocinonide.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Fluocinonide.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Fluocinonide.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Fluocinonide.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Fluocinonide.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Fluocinonide.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Fluocinonide.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Fluocinonide.
Cladribine Fluocinonide may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Fluocinonide.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Fluocinonide.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluocinonide.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Fluocinonide.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Fluocinonide.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Fluocinonide.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Fluocinonide.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Fluocinonide.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Fluocinonide.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Fluocinonide.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Fluocinonide.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Fluocinonide.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Fluocinonide.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Fluocinonide.
Betamethasone The risk or severity of adverse effects can be increased when Betamethasone is combined with Fluocinonide.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Fluocinonide.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Fluocinonide.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Fluocinonide.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Fluocinonide.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Fluocinonide.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Fluocinonide.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Fluocinonide.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Fluocinonide.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Fluocinonide.
Fluticasone propionate The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Fluocinonide.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Fluocinonide.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Fluocinonide.
Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Fluocinonide.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Fluocinonide.
Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Fluocinonide.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Fluocinonide.
Fludrocortisone The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Fluocinonide.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Fluocinonide.
Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Fluocinonide.
Tretinoin The metabolism of Tretinoin can be increased when combined with Fluocinonide.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Fluocinonide.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Fluocinonide.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Fluocinonide.
Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Fluocinonide.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Fluocinonide.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Fluocinonide.
Methylprednisolone The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Fluocinonide.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Fluocinonide.
Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Fluocinonide.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Fluocinonide.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Fluocinonide.
Clobetasol propionate The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Fluocinonide.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Fluocinonide.
Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Fluocinonide.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Fluocinonide.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Fluocinonide.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Fluocinonide.
Fludarabine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Fludarabine.
Flucytosine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Flucytosine.
Capecitabine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Capecitabine.
Procarbazine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Procarbazine.
Arsenic trioxide The risk or severity of adverse effects can be increased when Fluocinonide is combined with Arsenic trioxide.
Idarubicin The risk or severity of adverse effects can be increased when Fluocinonide is combined with Idarubicin.
Estramustine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Estramustine.
Mitoxantrone The risk or severity of adverse effects can be increased when Fluocinonide is combined with Mitoxantrone.
Lomustine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Lomustine.
Budesonide The risk or severity of adverse effects can be increased when Fluocinonide is combined with Budesonide.
Dexamethasone The risk or severity of adverse effects can be increased when Fluocinonide is combined with Dexamethasone.
Eculizumab The risk or severity of adverse effects can be increased when Fluocinonide is combined with Eculizumab.
Decitabine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Decitabine.
Nelarabine The risk or severity of adverse effects can be increased when Fluocinonide is combined with Nelarabine.
Abatacept The risk or severity of adverse effects can be increased when Fluocinonide is combined with Abatacept.
Corticotropin The risk or severity of adverse effects can be increased when Fluocinonide is combined with Corticotropin.
Cortisone acetate The risk or severity of adverse effects can be increased when Fluocinonide is combined with Cortisone acetate.
Paramethasone The risk or severity of adverse effects can be increased when Fluocinonide is combined with Paramethasone.
Ciclesonide The risk or severity of adverse effects can be increased when Fluocinonide is combined with Ciclesonide.

Target Protein

Steroid hormone receptor ERR1 ESRRA
Steroid hormone receptor ERR2 ESRRB
Estrogen-related receptor gamma ESRRG
Glucocorticoid receptor NR3C1
Protein smoothened SMO

Referensi & Sumber

Synthesis reference: US. Patent 3,197,469.

Contoh Produk & Brand

Produk: 180 • International brands: 6
Produk
  • Flumethovix
    Kit • - • Topical • US • Generic • Approved
  • Fluocinol Pak
    Cream; Kit • 1 mg/1g • Topical • US
  • Fluocinonide
    Solution • 0.5 mg/1mL • Topical • US • Generic • Approved
  • Fluocinonide
    Cream • 0.5 mg/1g • Topical • US • Generic • Approved
  • Fluocinonide
    Gel • 0.5 mg/1g • Topical • US • Generic • Approved
  • Fluocinonide
    Ointment • 0.5 mg/1g • Topical • US • Generic • Approved
  • Fluocinonide
    Cream • 0.5 mg/1g • Topical • US • Generic • Approved
  • Fluocinonide
    Cream • 0.5 mg/1g • Topical • US • Generic • Approved
Menampilkan 8 dari 180 produk.
International Brands
  • Fluonex
  • Lonide
  • Lyderm — Taro
  • Metosyn — Bioglan
  • Topsymin
  • Topsyn — Syntex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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