In a definitive Phase 1 cardiac repolarization study, 51 patients were administered a single oral dose of 144 mcg of lubiprostone, which is 6 times the normal single administration dose. Thirty-nine (39) of the 51 patients experienced an adverse event. The adverse events reported in >1% of this group included the following: nausea (45.1%), vomiting (27.5%), diarrhea (25.5%), dizziness (17.6%), loose or watery stools (13.7%), headache (11.8%), retching (7.8%), abdominal pain (5.9%), flushing or hot flush (5.9%), dyspnea (3.9%), pallor (3.9%), stomach discomfort (3.9%), syncope (3.9%), upper abdominal pain (2.0%), anorexia (2.0%), asthenia (2.0%), chest discomfort (2.0%), dry mouth (2.0%), hyperhidrosis (2.0%), skin irritation (2.0%) and vasovagal episode (2.0%).
Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and induce spontaneous bowel movements (SBM).
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Methadone | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Methadone. |
| Trospium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Trospium. |
| Oxyphenonium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Oxyphenonium. |
| Ziprasidone | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Ziprasidone. |
| Ipratropium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Ipratropium. |
| Olanzapine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Olanzapine. |
| Metixene | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Metixene. |
| Terfenadine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Terfenadine. |
| Buclizine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Buclizine. |
| Doxylamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Doxylamine. |
| Trihexyphenidyl | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Trihexyphenidyl. |
| Oxyphencyclimine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Oxyphencyclimine. |
| Procyclidine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Procyclidine. |
| Profenamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Profenamine. |
| Promazine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Promazine. |
| Hyoscyamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Hyoscyamine. |
| Cyproheptadine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Cyproheptadine. |
| Methscopolamine bromide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Methscopolamine bromide. |
| Gallamine triethiodide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Gallamine triethiodide. |
| Darifenacin | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Darifenacin. |
| Tridihexethyl | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Tridihexethyl. |
| Triflupromazine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Triflupromazine. |
| Anisotropine methylbromide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Anisotropine methylbromide. |
| Nortriptyline | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Nortriptyline. |
| Amoxapine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Amoxapine. |
| Atropine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Atropine. |
| Nicardipine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Nicardipine. |
| Pirenzepine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Pirenzepine. |
| Paroxetine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Paroxetine. |
| Homatropine methylbromide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Homatropine methylbromide. |
| Rocuronium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Rocuronium. |
| Scopolamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Scopolamine. |
| Benzquinamide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Benzquinamide. |
| Clidinium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Clidinium. |
| Propiomazine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Propiomazine. |
| Biperiden | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Biperiden. |
| Brompheniramine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Brompheniramine. |
| Flupentixol | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Flupentixol. |
| Cocaine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Cocaine. |
| Methantheline | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Methantheline. |
| Cycrimine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Cycrimine. |
| Glycopyrronium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Glycopyrronium. |
| Oxybutynin | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Oxybutynin. |
| Diphenhydramine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Diphenhydramine. |
| Orphenadrine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Orphenadrine. |
| Escitalopram | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Escitalopram. |
| Mivacurium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Mivacurium. |
| Diphenidol | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Diphenidol. |
| Aripiprazole | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Aripiprazole. |
| Chlorprothixene | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Chlorprothixene. |
| Metocurine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Metocurine. |
| Pancuronium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Pancuronium. |
| Pipecuronium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Pipecuronium. |
| Methotrimeprazine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Methotrimeprazine. |
| Solifenacin | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Solifenacin. |
| Isopropamide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Isopropamide. |
| Rapacuronium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Rapacuronium. |
| Mepenzolate | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Mepenzolate. |
| Pizotifen | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Pizotifen. |
| Hexocyclium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Hexocyclium. |
| Dimetindene | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Dimetindene. |
| Dexetimide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Dexetimide. |
| Benactyzine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Benactyzine. |
| Umeclidinium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Umeclidinium. |
| Dosulepin | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Dosulepin. |
| Butylscopolamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Butylscopolamine. |
| Thonzylamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Thonzylamine. |
| Methscopolamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Methscopolamine. |
| Revefenacin | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Revefenacin. |
| Oxitropium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Oxitropium. |
| Batefenterol | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Batefenterol. |
| Mebeverine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Mebeverine. |
| Tropatepine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Tropatepine. |
| Prifinium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Prifinium. |
| Piperidolate | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Piperidolate. |
| Benzilone | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Benzilone. |
| Difemerine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Difemerine. |
| Phenglutarimide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Phenglutarimide. |
| Mazaticol | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Mazaticol. |
| Etybenzatropine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Etybenzatropine. |
| Otilonium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Otilonium. |
| Emepronium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Emepronium. |
| Poldine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Poldine. |
| Bevonium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Bevonium. |
| Rociverine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Rociverine. |
| Bornaprine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Bornaprine. |
| Etanautine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Etanautine. |
| Tiemonium iodide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Tiemonium iodide. |
| Dihexyverine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Dihexyverine. |
| Penthienate | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Penthienate. |
| Diphemanil | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Diphemanil. |
| Camylofin | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Camylofin. |
| Fenpiverinium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Fenpiverinium. |
| Emetonium iodide | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Emetonium iodide. |
| Pipenzolate | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Pipenzolate. |
| Timepidium | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Timepidium. |
| Desipramine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Desipramine. |
| Chlorphenoxamine | The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Chlorphenoxamine. |
| Torasemide | The risk or severity of dehydration can be increased when Torasemide is combined with Lubiprostone. |
| Methyclothiazide | The risk or severity of dehydration can be increased when Methyclothiazide is combined with Lubiprostone. |