Carphenazine

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

25 Data

Tetrabenazine	The risk or severity of adverse effects can be increased when Carphenazine is combined with Tetrabenazine.
Deutetrabenazine	The risk or severity of adverse effects can be increased when Carphenazine is combined with Deutetrabenazine.
Apomorphine	The therapeutic efficacy of Apomorphine can be decreased when used in combination with Carphenazine.
Bromocriptine	The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Carphenazine.
Levodopa	The therapeutic efficacy of Levodopa can be decreased when used in combination with Carphenazine.
Rotigotine	The therapeutic efficacy of Rotigotine can be decreased when used in combination with Carphenazine.
Piribedil	The therapeutic efficacy of Piribedil can be decreased when used in combination with Carphenazine.
Cabergoline	The therapeutic efficacy of Cabergoline can be decreased when used in combination with Carphenazine.
Dihydroergotamine	The therapeutic efficacy of Dihydroergotamine can be decreased when used in combination with Carphenazine.
Lisuride	The therapeutic efficacy of Lisuride can be decreased when used in combination with Carphenazine.
Fenoldopam	The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Carphenazine.
Ergoloid mesylate	The therapeutic efficacy of Ergoloid mesylate can be decreased when used in combination with Carphenazine.
Pergolide	The therapeutic efficacy of Pergolide can be decreased when used in combination with Carphenazine.
Aripiprazole	The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Carphenazine.
Quinagolide	The therapeutic efficacy of Quinagolide can be decreased when used in combination with Carphenazine.
Brexpiprazole	The therapeutic efficacy of Brexpiprazole can be decreased when used in combination with Carphenazine.
Dihydroergocornine	The therapeutic efficacy of Dihydroergocornine can be decreased when used in combination with Carphenazine.
Dopexamine	The therapeutic efficacy of Dopexamine can be decreased when used in combination with Carphenazine.
Dihydrexidine	The therapeutic efficacy of Dihydrexidine can be decreased when used in combination with Carphenazine.
Dihydroergocryptine	The therapeutic efficacy of Dihydroergocryptine can be decreased when used in combination with Carphenazine.
Metergoline	The therapeutic efficacy of Metergoline can be decreased when used in combination with Carphenazine.
Ropinirole	The therapeutic efficacy of Ropinirole can be decreased when used in combination with Carphenazine.
Benzatropine	The risk or severity of adverse effects can be increased when Carphenazine is combined with Benzatropine.
Pramipexole	The therapeutic efficacy of Pramipexole can be decreased when used in combination with Carphenazine.
Epicriptine	The therapeutic efficacy of Epicriptine can be decreased when used in combination with Carphenazine.

Target Protein

D(2) dopamine receptor DRD2

D(1A) dopamine receptor DRD1

D(1B) dopamine receptor DRD5

Referensi & Sumber

Synthesis reference: Tislow, R.F., Bruce, W.F. and Page, J.A.; US. Patent 3,023,146; February 27,1962; assigned to American Home Products Corporation. Sherlock, M.H. and Sperber, N.; US. Patent 2,985,654; May 23, 1961; assigned to Schering Corporation.

Contoh Produk & Brand

Produk: 0 • International brands: 2

International Brands

Proketazin
Proketazine — Wyeth

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Deskripsi

Struktur Molekul 2D

Deskripsi metode visualisasi