Peringatan Keamanan

LD50=63 mg/kg (rats, IV)

Selegiline

DB01037

small molecule approved investigational vet_approved

Deskripsi

A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.

Struktur Molekul 2D

Berat 187.286
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.2-2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed from the gastrointestinal tract.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

3 Data
  • 1. Avoid tyramine-containing foods and supplements. Consuming foods containing tyramine such as yogurt, aged cheese, ripe bananas, wine, and sourdough bread may increase the risk of having an uncontrolled hypertensive reaction.
  • 2. Take before a meal. Take selegiline oral disintegrating tablets before breakfast and at least 5 minutes before or after any food or drink. Taking selegiline with food reduces the AUC by approximately 60%.
  • 3. Take with food. Take selegiline capsules or tablets with breakfast and lunch. Food can increase the exposure to selegiline by 3-4 fold.

Interaksi Obat

1812 Data
Risperidone Selegiline may increase the hypotensive activities of Risperidone.
Deferasirox The serum concentration of Selegiline can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Selegiline can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Selegiline can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Selegiline can be decreased when it is combined with Teriflunomide.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Magnesium sulfate The therapeutic efficacy of Selegiline can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Selegiline may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Selegiline may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Orphenadrine Selegiline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Selegiline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Selegiline.
Pramipexole Selegiline may increase the sedative activities of Pramipexole.
Rotigotine Selegiline may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Selegiline.
Sodium oxybate Selegiline may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Selegiline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Selegiline may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Selegiline may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Selegiline.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Selegiline.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Selegiline.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Selegiline.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Selegiline.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Selegiline.
Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Selegiline.
Carprofen The risk or severity of hypertension can be increased when Carprofen is combined with Selegiline.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Selegiline.
Diflunisal The risk or severity of hypertension can be increased when Diflunisal is combined with Selegiline.
Meclofenamic acid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Selegiline.
Oxaprozin The risk or severity of hypertension can be increased when Oxaprozin is combined with Selegiline.
Balsalazide The risk or severity of hypertension can be increased when Balsalazide is combined with Selegiline.
Ephedrine The risk or severity of hypertension can be increased when Selegiline is combined with Ephedrine.
Magnesium salicylate The risk or severity of hypertension can be increased when Selegiline is combined with Magnesium salicylate.
Salsalate The risk or severity of hypertension can be increased when Selegiline is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Selegiline is combined with Choline magnesium trisalicylate.
Antrafenine The risk or severity of hypertension can be increased when Selegiline is combined with Antrafenine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Selegiline is combined with Tiaprofenic acid.
Epicaptopril The risk or severity of hypertension can be increased when Selegiline is combined with Epicaptopril.
Taxifolin The risk or severity of hypertension can be increased when Selegiline is combined with Taxifolin.
Oxyphenbutazone The risk or severity of hypertension can be increased when Selegiline is combined with Oxyphenbutazone.
1-benzylimidazole The risk or severity of hypertension can be increased when Selegiline is combined with 1-benzylimidazole.
Benoxaprofen The risk or severity of hypertension can be increased when Selegiline is combined with Benoxaprofen.
Cimicoxib The risk or severity of hypertension can be increased when Selegiline is combined with Cimicoxib.
Amibegron The risk or severity of hypertension can be increased when Selegiline is combined with Amibegron.
Solabegron The risk or severity of hypertension can be increased when Selegiline is combined with Solabegron.
Saralasin The risk or severity of hypertension can be increased when Selegiline is combined with Saralasin.
Azapropazone The risk or severity of hypertension can be increased when Selegiline is combined with Azapropazone.
Salicylamide The risk or severity of hypertension can be increased when Selegiline is combined with Salicylamide.
Tyramine The risk or severity of hypertension can be increased when Selegiline is combined with Tyramine.
Adrafinil The risk or severity of hypertension can be increased when Selegiline is combined with Adrafinil.
Kebuzone The risk or severity of hypertension can be increased when Selegiline is combined with Kebuzone.
Isoxicam The risk or severity of hypertension can be increased when Selegiline is combined with Isoxicam.
Indoprofen The risk or severity of hypertension can be increased when Selegiline is combined with Indoprofen.
Ibuproxam The risk or severity of hypertension can be increased when Selegiline is combined with Ibuproxam.
Floctafenine The risk or severity of hypertension can be increased when Selegiline is combined with Floctafenine.
Fenbufen The risk or severity of hypertension can be increased when Selegiline is combined with Fenbufen.
Etofenamate The risk or severity of hypertension can be increased when Selegiline is combined with Etofenamate.
Etilefrine The risk or severity of hypertension can be increased when Selegiline is combined with Etilefrine.
Epirizole The risk or severity of hypertension can be increased when Selegiline is combined with Epirizole.
Benzydamine The risk or severity of hypertension can be increased when Selegiline is combined with Benzydamine.
Synephrine The risk or severity of hypertension can be increased when Selegiline is combined with Synephrine.
Moxisylyte The risk or severity of hypertension can be increased when Selegiline is combined with Moxisylyte.
Dexketoprofen The risk or severity of hypertension can be increased when Selegiline is combined with Dexketoprofen.
Droxicam The risk or severity of hypertension can be increased when Selegiline is combined with Droxicam.
Firocoxib The risk or severity of hypertension can be increased when Selegiline is combined with Firocoxib.
Clonixin The risk or severity of hypertension can be increased when Selegiline is combined with Clonixin.
Morniflumate The risk or severity of hypertension can be increased when Selegiline is combined with Morniflumate.
Talniflumate The risk or severity of hypertension can be increased when Selegiline is combined with Talniflumate.
DL-Methylephedrine The risk or severity of hypertension can be increased when Selegiline is combined with DL-Methylephedrine.
Amitraz The risk or severity of hypertension can be increased when Selegiline is combined with Amitraz.
Robenacoxib The risk or severity of hypertension can be increased when Selegiline is combined with Robenacoxib.
Tepoxalin The risk or severity of hypertension can be increased when Selegiline is combined with Tepoxalin.
Atipamezole The risk or severity of hypertension can be increased when Selegiline is combined with Atipamezole.
Flunixin The risk or severity of hypertension can be increased when Selegiline is combined with Flunixin.
Ractopamine The risk or severity of hypertension can be increased when Selegiline is combined with Ractopamine.
Tulobuterol The risk or severity of hypertension can be increased when Selegiline is combined with Tulobuterol.
Dopexamine The risk or severity of hypertension can be increased when Selegiline is combined with Dopexamine.
Idazoxan The risk or severity of hypertension can be increased when Selegiline is combined with Idazoxan.
Ebselen The risk or severity of hypertension can be increased when Selegiline is combined with Ebselen.
Higenamine The risk or severity of hypertension can be increased when Selegiline is combined with Higenamine.
Reproterol The risk or severity of hypertension can be increased when Selegiline is combined with Reproterol.
Tinoridine The risk or severity of hypertension can be increased when Selegiline is combined with Tinoridine.
Tramazoline The risk or severity of hypertension can be increased when Selegiline is combined with Tramazoline.
Alclofenac The risk or severity of hypertension can be increased when Selegiline is combined with Alclofenac.
Fentiazac The risk or severity of hypertension can be increased when Selegiline is combined with Fentiazac.
Suxibuzone The risk or severity of hypertension can be increased when Selegiline is combined with Suxibuzone.
Octopamine The risk or severity of hypertension can be increased when Selegiline is combined with Octopamine.
Bumadizone The risk or severity of hypertension can be increased when Selegiline is combined with Bumadizone.
Alminoprofen The risk or severity of hypertension can be increased when Selegiline is combined with Alminoprofen.
Fenozolone The risk or severity of hypertension can be increased when Selegiline is combined with Fenozolone.
Difenpiramide The risk or severity of hypertension can be increased when Selegiline is combined with Difenpiramide.
Norfenefrine The risk or severity of hypertension can be increased when Selegiline is combined with Norfenefrine.
Oxyfedrine The risk or severity of hypertension can be increased when Selegiline is combined with Oxyfedrine.
Nifenazone The risk or severity of hypertension can be increased when Selegiline is combined with Nifenazone.

Target Protein

Amine oxidase [flavin-containing] B MAOB
Substance-P receptor TACR1
Amine oxidase [flavin-containing] A MAOA

Referensi & Sumber

Synthesis reference: Silvia Ott-Dembrowski, Richard Cyrus, Jorg Schmidt, Hans Waiblinger, "Preparation of selegiline." U.S. Patent US5847216, issued March, 1962.
Artikel (PubMed)
  • PMID: 1658311
    Engberg G, Elebring T, Nissbrandt H: Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons. J Pharmacol Exp Ther. 1991 Nov;259(2):841-7.
  • PMID: 16034956
    Macleod AD, Counsell CE, Ives N, Stowe R: Monoamine oxidase B inhibitors for early Parkinson's disease. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004898.
  • PMID: 6441926
    Magyar K, Tothfalusi L: Pharmacokinetic aspects of deprenyl effects. Pol J Pharmacol Pharm. 1984 Jul-Aug;36(4):373-84.
  • PMID: 7995016
    Heinonen EH, Anttila MI, Lammintausta RA: Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites. Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):742-9.
  • PMID: 11978145
    Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309.
  • PMID: 18311418
    Culpepper L, Kovalick LJ: A review of the literature on the selegiline transdermal system: an effective and well-tolerated monoamine oxidase inhibitor for the treatment of depression. Prim Care Companion J Clin Psychiatry. 2008;10(1):25-30.
  • PMID: 19300583
    Lee KC, Chen JJ: Transdermal selegiline for the treatment of major depressive disorder. Neuropsychiatr Dis Treat. 2007;3(5):527-37.

Contoh Produk & Brand

Produk: 42 • International brands: 2
Produk
  • Dom-selegiline
    Tablet • 5 mg • Oral • Canada • Generic • Approved
  • Eldepryl
    Capsule • 5 mg/1 • Oral • US • Generic • Approved
  • Eldepryl
    Tablet • 5 mg/1 • Oral • US • Approved
  • Eldepryl
    Capsule • 5 mg/1 • Oral • US • Approved
  • Eldepryl - 5mg Tab
    Tablet • 5 mg • Oral • Canada • Approved
  • Eldepryl Tab 5mg
    Tablet • 5 mg • Oral • Canada • Approved
  • Emsam
    Patch • 6 mg/24h • Transdermal • US • Approved
  • Emsam
    Patch • 9 mg/24h • Transdermal • US • Approved
Menampilkan 8 dari 42 produk.
International Brands
  • Carbex
  • Jumex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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