Oral, mouse LD50: 547 mg/kg. Symptoms of overexposure include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, and headache.
Cerulenin is an antifungal agent whose activity interferes with or otherwise acts to prevent the formation of fatty acids and sterols. In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. It is also shown to inhibit feeding and induce dramatic weight loss in mice. It is found naturally in the Cephalosporium caerulensfungus.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Dicoumarol | The therapeutic efficacy of Dicoumarol can be increased when used in combination with Cerulenin. |
| Phenindione | The therapeutic efficacy of Phenindione can be increased when used in combination with Cerulenin. |
| Warfarin | The therapeutic efficacy of Warfarin can be increased when used in combination with Cerulenin. |
| Phenprocoumon | The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Cerulenin. |
| Acenocoumarol | The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Cerulenin. |
| 4-hydroxycoumarin | The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Cerulenin. |
| Coumarin | The therapeutic efficacy of Coumarin can be increased when used in combination with Cerulenin. |
| (R)-warfarin | The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Cerulenin. |
| Ethyl biscoumacetate | The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Cerulenin. |
| Fluindione | The therapeutic efficacy of Fluindione can be increased when used in combination with Cerulenin. |
| Clorindione | The therapeutic efficacy of Clorindione can be increased when used in combination with Cerulenin. |
| Diphenadione | The therapeutic efficacy of Diphenadione can be increased when used in combination with Cerulenin. |
| Tioclomarol | The therapeutic efficacy of Tioclomarol can be increased when used in combination with Cerulenin. |
| (S)-Warfarin | The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Cerulenin. |