The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Probenecid. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Probenecid. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Probenecid. |
| Lorazepam | The serum concentration of Lorazepam can be increased when it is combined with Probenecid. |
| Oseltamivir | The serum concentration of the active metabolites of Oseltamivir can be increased when Oseltamivir is used in combination with Probenecid. |
| Nicotine | The risk or severity of adverse effects can be increased when Probenecid is combined with Nicotine. |
| Mecamylamine | The risk or severity of adverse effects can be increased when Probenecid is combined with Mecamylamine. |
| Pentolinium | The risk or severity of adverse effects can be increased when Probenecid is combined with Pentolinium. |
| Trimethaphan | The risk or severity of adverse effects can be increased when Probenecid is combined with Trimethaphan. |
| Hexamethonium | The risk or severity of adverse effects can be increased when Probenecid is combined with Hexamethonium. |
| Cyclopentamine | The risk or severity of adverse effects can be increased when Probenecid is combined with Cyclopentamine. |
| Torasemide | The risk or severity of adverse effects can be increased when Probenecid is combined with Torasemide. |
| Furosemide | The risk or severity of adverse effects can be increased when Probenecid is combined with Furosemide. |
| Bumetanide | The risk or severity of adverse effects can be increased when Probenecid is combined with Bumetanide. |
| Etacrynic acid | The risk or severity of adverse effects can be increased when Probenecid is combined with Etacrynic acid. |
| Piretanide | The risk or severity of adverse effects can be increased when Probenecid is combined with Piretanide. |
| Azosemide | The risk or severity of adverse effects can be increased when Probenecid is combined with Azosemide. |
| Tripamide | The risk or severity of adverse effects can be increased when Probenecid is combined with Tripamide. |
| Moxifloxacin | Probenecid may decrease the excretion rate of Moxifloxacin which could result in a higher serum level. |
| Grepafloxacin | Probenecid may decrease the excretion rate of Grepafloxacin which could result in a higher serum level. |
| Enoxacin | Probenecid may decrease the excretion rate of Enoxacin which could result in a higher serum level. |
| Pefloxacin | Probenecid may decrease the excretion rate of Pefloxacin which could result in a higher serum level. |
| Ciprofloxacin | Probenecid may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level. |
| Trovafloxacin | Probenecid may decrease the excretion rate of Trovafloxacin which could result in a higher serum level. |
| Nalidixic acid | Probenecid may decrease the excretion rate of Nalidixic acid which could result in a higher serum level. |
| Rosoxacin | Probenecid may decrease the excretion rate of Rosoxacin which could result in a higher serum level. |
| Cinoxacin | Probenecid may decrease the excretion rate of Cinoxacin which could result in a higher serum level. |
| Lomefloxacin | Probenecid may decrease the excretion rate of Lomefloxacin which could result in a higher serum level. |
| Gatifloxacin | Probenecid may decrease the excretion rate of Gatifloxacin which could result in a higher serum level. |
| Norfloxacin | Probenecid may decrease the excretion rate of Norfloxacin which could result in a higher serum level. |
| Ofloxacin | Probenecid may decrease the excretion rate of Ofloxacin which could result in a higher serum level. |
| Sparfloxacin | Probenecid may decrease the excretion rate of Sparfloxacin which could result in a higher serum level. |
| Temafloxacin | Probenecid may decrease the excretion rate of Temafloxacin which could result in a higher serum level. |
| Fleroxacin | Probenecid may decrease the excretion rate of Fleroxacin which could result in a higher serum level. |
| Technetium Tc-99m ciprofloxacin | Probenecid may decrease the excretion rate of Technetium Tc-99m ciprofloxacin which could result in a higher serum level. |
| Garenoxacin | Probenecid may decrease the excretion rate of Garenoxacin which could result in a higher serum level. |
| Nemonoxacin | Probenecid may decrease the excretion rate of Nemonoxacin which could result in a higher serum level. |
| Flumequine | Probenecid may decrease the excretion rate of Flumequine which could result in a higher serum level. |
| Enrofloxacin | Probenecid may decrease the excretion rate of Enrofloxacin which could result in a higher serum level. |
| Orbifloxacin | Probenecid may decrease the excretion rate of Orbifloxacin which could result in a higher serum level. |
| Sarafloxacin | Probenecid may decrease the excretion rate of Sarafloxacin which could result in a higher serum level. |
| Difloxacin | Probenecid may decrease the excretion rate of Difloxacin which could result in a higher serum level. |
| Pazufloxacin | Probenecid may decrease the excretion rate of Pazufloxacin which could result in a higher serum level. |
| Prulifloxacin | Probenecid may decrease the excretion rate of Prulifloxacin which could result in a higher serum level. |
| Delafloxacin | Probenecid may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
| Sitafloxacin | Probenecid may decrease the excretion rate of Sitafloxacin which could result in a higher serum level. |
| Oxolinic acid | Probenecid may decrease the excretion rate of Oxolinic acid which could result in a higher serum level. |
| Rufloxacin | Probenecid may decrease the excretion rate of Rufloxacin which could result in a higher serum level. |
| Pipemidic acid | Probenecid may decrease the excretion rate of Pipemidic acid which could result in a higher serum level. |
| Glimepiride | The protein binding of Glimepiride can be decreased when combined with Probenecid. |
| Acetohexamide | The protein binding of Acetohexamide can be decreased when combined with Probenecid. |
| Chlorpropamide | The protein binding of Chlorpropamide can be decreased when combined with Probenecid. |
| Tolazamide | The protein binding of Tolazamide can be decreased when combined with Probenecid. |
| Glyburide | The protein binding of Glyburide can be decreased when combined with Probenecid. |
| Glipizide | The protein binding of Glipizide can be decreased when combined with Probenecid. |
| Gliclazide | The protein binding of Gliclazide can be decreased when combined with Probenecid. |
| Tolbutamide | The protein binding of Tolbutamide can be decreased when combined with Probenecid. |
| Gliquidone | The protein binding of Gliquidone can be decreased when combined with Probenecid. |
| Glisoxepide | The protein binding of Glisoxepide can be decreased when combined with Probenecid. |
| Glibornuride | The protein binding of Glibornuride can be decreased when combined with Probenecid. |
| Carbutamide | The protein binding of Carbutamide can be decreased when combined with Probenecid. |
| Metahexamide | The protein binding of Metahexamide can be decreased when combined with Probenecid. |
| Irinotecan | The risk or severity of neutropenia can be increased when Probenecid is combined with Irinotecan. |
| Aminosalicylic acid | The therapeutic efficacy of Probenecid can be decreased when used in combination with Aminosalicylic acid. |
| Bismuth subsalicylate | The therapeutic efficacy of Probenecid can be decreased when used in combination with Bismuth subsalicylate. |
| Dersalazine | The therapeutic efficacy of Probenecid can be decreased when used in combination with Dersalazine. |
| Phenyl aminosalicylate | The therapeutic efficacy of Probenecid can be decreased when used in combination with Phenyl aminosalicylate. |
| Methyl salicylate | The therapeutic efficacy of Probenecid can be decreased when used in combination with Methyl salicylate. |
| Aloxiprin | The therapeutic efficacy of Probenecid can be decreased when used in combination with Aloxiprin. |
| Choline salicylate | The therapeutic efficacy of Probenecid can be decreased when used in combination with Choline salicylate. |
| Thiosalicylic acid | The therapeutic efficacy of Probenecid can be decreased when used in combination with Thiosalicylic acid. |
| Dapsone | Probenecid may decrease the excretion rate of Dapsone which could result in a higher serum level. |
| Ertapenem | Probenecid may decrease the excretion rate of Ertapenem which could result in a higher serum level. |
| Flucloxacillin | The excretion of Flucloxacillin can be decreased when combined with Probenecid. |
| Piperacillin | The excretion of Piperacillin can be decreased when combined with Probenecid. |
| Phenoxymethylpenicillin | The excretion of Phenoxymethylpenicillin can be decreased when combined with Probenecid. |
| Dicloxacillin | The excretion of Dicloxacillin can be decreased when combined with Probenecid. |
| Carbenicillin | The excretion of Carbenicillin can be decreased when combined with Probenecid. |
| Nafcillin | The excretion of Nafcillin can be decreased when combined with Probenecid. |
| Oxacillin | The excretion of Oxacillin can be decreased when combined with Probenecid. |
| Hetacillin | The excretion of Hetacillin can be decreased when combined with Probenecid. |
| Benzylpenicilloyl polylysine | The excretion of Benzylpenicilloyl polylysine can be decreased when combined with Probenecid. |
| Mezlocillin | The excretion of Mezlocillin can be decreased when combined with Probenecid. |
| Cyclacillin | The excretion of Cyclacillin can be decreased when combined with Probenecid. |
| Benzylpenicillin | The excretion of Benzylpenicillin can be decreased when combined with Probenecid. |
| Amoxicillin | The excretion of Amoxicillin can be decreased when combined with Probenecid. |
| Azlocillin | The excretion of Azlocillin can be decreased when combined with Probenecid. |
| Cloxacillin | The excretion of Cloxacillin can be decreased when combined with Probenecid. |
| Amdinocillin | The excretion of Amdinocillin can be decreased when combined with Probenecid. |
| Bacampicillin | The excretion of Bacampicillin can be decreased when combined with Probenecid. |
| Meticillin | The excretion of Meticillin can be decreased when combined with Probenecid. |
| Pivampicillin | The excretion of Pivampicillin can be decreased when combined with Probenecid. |
| Pivmecillinam | The excretion of Pivmecillinam can be decreased when combined with Probenecid. |
| Ticarcillin | The excretion of Ticarcillin can be decreased when combined with Probenecid. |
| Azidocillin | The excretion of Azidocillin can be decreased when combined with Probenecid. |
| Carindacillin | The excretion of Carindacillin can be decreased when combined with Probenecid. |
| Procaine benzylpenicillin | The excretion of Procaine benzylpenicillin can be decreased when combined with Probenecid. |
| Sultamicillin | The excretion of Sultamicillin can be decreased when combined with Probenecid. |
| Temocillin | The excretion of Temocillin can be decreased when combined with Probenecid. |
| Epicillin | The excretion of Epicillin can be decreased when combined with Probenecid. |