LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
In the US, methoxyflurane is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness.L43942
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ramipril | Methoxyflurane may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Methoxyflurane may decrease the antihypertensive activities of Remikiren. |
| Guanadrel | Methoxyflurane may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Methoxyflurane may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Methoxyflurane may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Methoxyflurane may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Methoxyflurane may decrease the antihypertensive activities of Minoxidil. |
| Bendroflumethiazide | Methoxyflurane may decrease the antihypertensive activities of Bendroflumethiazide. |
| Prazosin | Methoxyflurane may decrease the antihypertensive activities of Prazosin. |
| Fosinopril | Methoxyflurane may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Methoxyflurane may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Methoxyflurane may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Methoxyflurane may decrease the antihypertensive activities of Benazepril. |
| Cyclothiazide | Methoxyflurane may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Methoxyflurane may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Methoxyflurane may decrease the antihypertensive activities of Mecamylamine. |
| Moexipril | Methoxyflurane may decrease the antihypertensive activities of Moexipril. |
| Lisinopril | Methoxyflurane may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Methoxyflurane may decrease the antihypertensive activities of Nitroglycerin. |
| Hydroflumethiazide | Methoxyflurane may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Methoxyflurane may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Methoxyflurane may decrease the antihypertensive activities of Perindopril. |
| Fenoldopam | Methoxyflurane may decrease the antihypertensive activities of Fenoldopam. |
| Eprosartan | Methoxyflurane may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Methoxyflurane may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Methoxyflurane may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Methoxyflurane may decrease the antihypertensive activities of Telmisartan. |
| Methyldopa | Methoxyflurane may decrease the antihypertensive activities of Methyldopa. |
| Hydrochlorothiazide | Methoxyflurane may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Methoxyflurane may decrease the antihypertensive activities of Trichlormethiazide. |
| Deserpidine | Methoxyflurane may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Methoxyflurane may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Methoxyflurane may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Methoxyflurane may decrease the antihypertensive activities of Diazoxide. |
| Bretylium | Methoxyflurane may decrease the antihypertensive activities of Bretylium. |
| Terazosin | Methoxyflurane may decrease the antihypertensive activities of Terazosin. |
| Epoprostenol | Methoxyflurane may decrease the antihypertensive activities of Epoprostenol. |
| Polythiazide | Methoxyflurane may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Methoxyflurane may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Methoxyflurane may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Methoxyflurane may decrease the antihypertensive activities of Spirapril. |
| Dexpropranolol | Methoxyflurane may decrease the antihypertensive activities of Dexpropranolol. |
| Diethylnorspermine | Methoxyflurane may decrease the antihypertensive activities of Diethylnorspermine. |
| Temocapril | Methoxyflurane may decrease the antihypertensive activities of Temocapril. |
| Trimazosin | Methoxyflurane may decrease the antihypertensive activities of Trimazosin. |
| Nicorandil | Methoxyflurane may decrease the antihypertensive activities of Nicorandil. |
| Rauwolfia serpentina root | Methoxyflurane may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Methoxyflurane may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Methoxyflurane may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Methoxyflurane may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Methoxyflurane may decrease the antihypertensive activities of BQ-123. |
| Cicletanine | Methoxyflurane may decrease the antihypertensive activities of Cicletanine. |
| Dihydralazine | Methoxyflurane may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Methoxyflurane may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Methoxyflurane may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Methoxyflurane may decrease the antihypertensive activities of Delapril. |
| Vincamine | Methoxyflurane may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Methoxyflurane may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Methoxyflurane may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Methoxyflurane may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Methoxyflurane may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Methoxyflurane may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Methoxyflurane may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Methoxyflurane may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Methoxyflurane may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Methoxyflurane may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Methoxyflurane may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Methoxyflurane may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Methoxyflurane may decrease the antihypertensive activities of Xipamide. |
| Tocopherylquinone | Methoxyflurane may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Methoxyflurane may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Methoxyflurane may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Methoxyflurane may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Methoxyflurane may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Methoxyflurane may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Methoxyflurane may decrease the antihypertensive activities of Furosemide. |
| Enalapril | Methoxyflurane may decrease the antihypertensive activities of Enalapril. |
| Captopril | Methoxyflurane may decrease the antihypertensive activities of Captopril. |
| Isradipine | The metabolism of Methoxyflurane can be decreased when combined with Isradipine. |
| Diltiazem | The metabolism of Methoxyflurane can be decreased when combined with Diltiazem. |
| Nimodipine | Methoxyflurane may decrease the antihypertensive activities of Nimodipine. |
| Nisoldipine | Methoxyflurane may decrease the antihypertensive activities of Nisoldipine. |
| Propranolol | Methoxyflurane may decrease the antihypertensive activities of Propranolol. |
| Doxazosin | Methoxyflurane may decrease the antihypertensive activities of Doxazosin. |
| Bisoprolol | Methoxyflurane may decrease the antihypertensive activities of Bisoprolol. |
| Losartan | Methoxyflurane may decrease the antihypertensive activities of Losartan. |
| Eplerenone | Methoxyflurane may decrease the antihypertensive activities of Eplerenone. |
| Indapamide | Methoxyflurane may decrease the antihypertensive activities of Indapamide. |
| Tadalafil | Methoxyflurane may decrease the antihypertensive activities of Tadalafil. |
| Irbesartan | Methoxyflurane may decrease the antihypertensive activities of Irbesartan. |
| Nitrendipine | Methoxyflurane may decrease the antihypertensive activities of Nitrendipine. |
| Guanethidine | Methoxyflurane may decrease the antihypertensive activities of Guanethidine. |
| Hydralazine | Methoxyflurane may decrease the antihypertensive activities of Hydralazine. |
| Nebivolol | Methoxyflurane may decrease the antihypertensive activities of Nebivolol. |
| Ambrisentan | Methoxyflurane may decrease the antihypertensive activities of Ambrisentan. |
| Pinacidil | Methoxyflurane may decrease the antihypertensive activities of Pinacidil. |
| Riociguat | Methoxyflurane may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Methoxyflurane may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Methoxyflurane may decrease the antihypertensive activities of Aliskiren. |
| Efonidipine | Methoxyflurane may decrease the antihypertensive activities of Efonidipine. |