Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly bradycardia. Oral rat LD50 is 1050 mg/kg.
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Felodipine is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Felodipine is combined with Levodopa. |
| Risperidone | Felodipine may increase the hypotensive activities of Risperidone. |
| Ursodeoxycholic acid | Ursodeoxycholic acid may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Cholic Acid | Cholic Acid may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Valinomycin | Valinomycin may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Olmesartan | Olmesartan may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Fusidic acid | Fusidic acid may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Simeprevir | Simeprevir may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Lenvatinib | Lenvatinib may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Pralsetinib | Pralsetinib may decrease the excretion rate of Felodipine which could result in a higher serum level. |
| Ceritinib | Felodipine may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Felodipine may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Felodipine. |
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Felodipine. |
| Amifostine | Felodipine may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Felodipine. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Felodipine. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Felodipine. |
| Obinutuzumab | Felodipine may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Felodipine. |
| Rituximab | Felodipine may increase the hypotensive activities of Rituximab. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Felodipine. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Felodipine. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Felodipine. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Felodipine. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Felodipine. |
| Rizatriptan | Rizatriptan may decrease the antihypertensive activities of Felodipine. |
| Dopamine | Dopamine may decrease the antihypertensive activities of Felodipine. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Felodipine. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Felodipine. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Felodipine. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Felodipine. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Felodipine. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Felodipine. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Felodipine. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Felodipine. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Felodipine. |
| Dimetacrine | Dimetacrine may decrease the antihypertensive activities of Felodipine. |
| Moxisylyte | Moxisylyte may decrease the antihypertensive activities of Felodipine. |
| Oxaprotiline | Oxaprotiline may decrease the antihypertensive activities of Felodipine. |
| Atipamezole | Atipamezole may decrease the antihypertensive activities of Felodipine. |
| Tetrahydrocannabivarin | Tetrahydrocannabivarin may decrease the antihypertensive activities of Felodipine. |
| Piclozotan | Piclozotan may decrease the antihypertensive activities of Felodipine. |
| Idazoxan | Idazoxan may decrease the antihypertensive activities of Felodipine. |
| Tramazoline | Tramazoline may decrease the antihypertensive activities of Felodipine. |
| Amitriptylinoxide | Amitriptylinoxide may decrease the antihypertensive activities of Felodipine. |
| Dibenzepin | Dibenzepin may decrease the antihypertensive activities of Felodipine. |
| Quinupramine | Quinupramine may decrease the antihypertensive activities of Felodipine. |
| Trichloroethylene | Trichloroethylene may decrease the antihypertensive activities of Felodipine. |
| Fenozolone | Fenozolone may decrease the antihypertensive activities of Felodipine. |
| Melitracen | Melitracen may decrease the antihypertensive activities of Felodipine. |
| Lofepramine | Lofepramine may decrease the antihypertensive activities of Felodipine. |
| Xenon | Xenon may decrease the antihypertensive activities of Felodipine. |
| Iprindole | Iprindole may decrease the antihypertensive activities of Felodipine. |
| Buflomedil | Buflomedil may decrease the antihypertensive activities of Felodipine. |
| Diethyl ether | Diethyl ether may decrease the antihypertensive activities of Felodipine. |
| Imipramine oxide | Imipramine oxide may decrease the antihypertensive activities of Felodipine. |
| Mefenorex | Mefenorex may decrease the antihypertensive activities of Felodipine. |
| Quinoline Yellow WS | Quinoline Yellow WS may decrease the antihypertensive activities of Felodipine. |
| Solriamfetol | Solriamfetol may decrease the antihypertensive activities of Felodipine. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Felodipine. |
| Metergoline | Metergoline may decrease the antihypertensive activities of Felodipine. |
| Theodrenaline | Theodrenaline may decrease the antihypertensive activities of Felodipine. |
| Bethanidine | Bethanidine may decrease the antihypertensive activities of Felodipine. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Felodipine. |
| Etomidate | Etomidate may decrease the antihypertensive activities of Felodipine. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Felodipine. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Felodipine. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Felodipine. |
| Guanabenz | Guanabenz may decrease the antihypertensive activities of Felodipine. |
| Dexmedetomidine | Dexmedetomidine may decrease the antihypertensive activities of Felodipine. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Felodipine. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Felodipine. |
| Dobutamine | Dobutamine may decrease the antihypertensive activities of Felodipine. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Felodipine. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Felodipine. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Felodipine. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Felodipine. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Felodipine. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Felodipine. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Felodipine. |
| Ephedrine | Ephedrine may decrease the antihypertensive activities of Felodipine. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Felodipine. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Felodipine. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Felodipine. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Felodipine. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Felodipine. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Felodipine. |
| Droxidopa | Droxidopa may decrease the antihypertensive activities of Felodipine. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Felodipine. |
| Levonordefrin | Levonordefrin may decrease the antihypertensive activities of Felodipine. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Felodipine. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Felodipine. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Felodipine. |
| Isoxsuprine | Isoxsuprine may decrease the antihypertensive activities of Felodipine. |
| Hexoprenaline | Hexoprenaline may decrease the antihypertensive activities of Felodipine. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Felodipine. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Felodipine. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Felodipine. |