Peringatan Keamanan

Symptoms of bethanechol overdose include nausea, vomiting, abdominal discomfort, salivation, sweating, and flushing of the skin.L32539

In case of overdose, atropine sulfate is available as an antidote and although subcutaneous administration is preferred, it may be given intravenously in emergencies. In adults, the recommended dose of atropine is 0.6 mg and may be repeated every 2 hours based on the patient’s response. In infants and children up to 12 years of age, the recommended dose of atropine is 0.01 mg/kg (maximum single dose = 0.4 mg) and may be repeated every 2 hours until the desired response is achieved or until adverse effects of atropine limit usage.L32539

In mice, the oral LD50 of bethanechol is 1510 mg/kg.L32539

Bethanechol

DB01019

small molecule approved

Deskripsi

Bethanechol is a synthetic ester that was initially synthesized in 1935.A232905,L32539 As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.A232905,L32539 For example, bethanechol is readily used to treat postoperative or postpartum urinary retention. An advantage of bethanechol is that in contrast to acetylcholine, bethanechol is not degraded by cholinesterase allowing its effects to be longer-lasting.L32539

Struktur Molekul 2D

Berat 161.2221
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

After oral administration of bethanechol, maximum effectiveness of the drug on the bladder and GI tract typically occur after 60-90 minutes; however, effects may present as early as 30 minutes after administration. The duration of action of a typical oral dose of bethanechol is around 1 hour while higher doses (300-400 mg) may be effective for up to 6 hours.L32539 Subcutaneously administered bethanechol produces effects more rapidly after 5-15 minutes with maximum effectiveness achieved after 15-30 minutes. The effects of subcutaneous bethanechol subside within 2 hours of administration.L32539

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Nausea and vomiting may occur if taken after food.

Interaksi Obat

130 Data
Esmolol The risk or severity of adverse effects can be increased when Esmolol is combined with Bethanechol.
Betaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with Bethanechol.
Metoprolol The risk or severity of adverse effects can be increased when Metoprolol is combined with Bethanechol.
Atenolol The risk or severity of adverse effects can be increased when Atenolol is combined with Bethanechol.
Timolol The risk or severity of adverse effects can be increased when Timolol is combined with Bethanechol.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Bethanechol.
Propranolol The risk or severity of adverse effects can be increased when Propranolol is combined with Bethanechol.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with Bethanechol.
Bisoprolol The risk or severity of adverse effects can be increased when Bisoprolol is combined with Bethanechol.
Alprenolol The risk or severity of adverse effects can be increased when Alprenolol is combined with Bethanechol.
Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Bethanechol.
Carvedilol The risk or severity of adverse effects can be increased when Carvedilol is combined with Bethanechol.
Propafenone The risk or severity of adverse effects can be increased when Propafenone is combined with Bethanechol.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Bethanechol.
Nadolol The risk or severity of adverse effects can be increased when Nadolol is combined with Bethanechol.
Bevantolol The risk or severity of adverse effects can be increased when Bevantolol is combined with Bethanechol.
Practolol The risk or severity of adverse effects can be increased when Practolol is combined with Bethanechol.
Penbutolol The risk or severity of adverse effects can be increased when Penbutolol is combined with Bethanechol.
Oxprenolol The risk or severity of adverse effects can be increased when Oxprenolol is combined with Bethanechol.
Dexpropranolol The risk or severity of adverse effects can be increased when Dexpropranolol is combined with Bethanechol.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with Bethanechol.
Nebivolol The risk or severity of adverse effects can be increased when Nebivolol is combined with Bethanechol.
Bufuralol The risk or severity of adverse effects can be increased when Bufuralol is combined with Bethanechol.
Bopindolol The risk or severity of adverse effects can be increased when Bopindolol is combined with Bethanechol.
Bupranolol The risk or severity of adverse effects can be increased when Bupranolol is combined with Bethanechol.
Indenolol The risk or severity of adverse effects can be increased when Indenolol is combined with Bethanechol.
Arotinolol The risk or severity of adverse effects can be increased when Arotinolol is combined with Bethanechol.
Levobetaxolol The risk or severity of adverse effects can be increased when Levobetaxolol is combined with Bethanechol.
Talinolol The risk or severity of adverse effects can be increased when Talinolol is combined with Bethanechol.
Anisodamine The risk or severity of adverse effects can be increased when Anisodamine is combined with Bethanechol.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with Bethanechol.
Esatenolol The risk or severity of adverse effects can be increased when Esatenolol is combined with Bethanechol.
Cloranolol The risk or severity of adverse effects can be increased when Cloranolol is combined with Bethanechol.
Mepindolol The risk or severity of adverse effects can be increased when Mepindolol is combined with Bethanechol.
Epanolol The risk or severity of adverse effects can be increased when Epanolol is combined with Bethanechol.
Tertatolol The risk or severity of adverse effects can be increased when Tertatolol is combined with Bethanechol.
Landiolol The risk or severity of adverse effects can be increased when Landiolol is combined with Bethanechol.
Cimetropium Bethanechol may decrease the anticholinergic activities of Cimetropium.
Pegvisomant The risk or severity of adverse effects can be increased when Pegvisomant is combined with Bethanechol.
Mefloquine The risk or severity of adverse effects can be increased when Mefloquine is combined with Bethanechol.
Tacrine The risk or severity of adverse effects can be increased when Tacrine is combined with Bethanechol.
Sulpiride The risk or severity of adverse effects can be increased when Sulpiride is combined with Bethanechol.
Profenamine The risk or severity of adverse effects can be increased when Profenamine is combined with Bethanechol.
Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Bethanechol.
Gallamine triethiodide The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Bethanechol.
Triflupromazine The risk or severity of adverse effects can be increased when Triflupromazine is combined with Bethanechol.
Cisplatin The risk or severity of adverse effects can be increased when Cisplatin is combined with Bethanechol.
Cinchocaine The risk or severity of adverse effects can be increased when Cinchocaine is combined with Bethanechol.
Pyridostigmine The risk or severity of adverse effects can be increased when Pyridostigmine is combined with Bethanechol.
Nizatidine The risk or severity of adverse effects can be increased when Nizatidine is combined with Bethanechol.
Galantamine The risk or severity of adverse effects can be increased when Galantamine is combined with Bethanechol.
Isoflurophate The risk or severity of adverse effects can be increased when Isoflurophate is combined with Bethanechol.
Diethylcarbamazine The risk or severity of adverse effects can be increased when Diethylcarbamazine is combined with Bethanechol.
Procaine The risk or severity of adverse effects can be increased when Procaine is combined with Bethanechol.
Minaprine The risk or severity of adverse effects can be increased when Minaprine is combined with Bethanechol.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with Bethanechol.
Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Bethanechol.
Hexafluronium The risk or severity of adverse effects can be increased when Hexafluronium is combined with Bethanechol.
Demecarium The risk or severity of adverse effects can be increased when Demecarium is combined with Bethanechol.
Physostigmine The risk or severity of adverse effects can be increased when Physostigmine is combined with Bethanechol.
Rivastigmine The risk or severity of adverse effects can be increased when Rivastigmine is combined with Bethanechol.
Edrophonium The risk or severity of adverse effects can be increased when Edrophonium is combined with Bethanechol.
Procainamide The risk or severity of adverse effects can be increased when Procainamide is combined with Bethanechol.
Memantine The risk or severity of adverse effects can be increased when Memantine is combined with Bethanechol.
Ambenonium The risk or severity of adverse effects can be increased when Ambenonium is combined with Bethanechol.
Ketamine The risk or severity of adverse effects can be increased when Ketamine is combined with Bethanechol.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Bethanechol.
Decamethonium The risk or severity of adverse effects can be increased when Decamethonium is combined with Bethanechol.
Pancuronium The risk or severity of adverse effects can be increased when Pancuronium is combined with Bethanechol.
Pipecuronium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Bethanechol.
Ginkgo biloba The risk or severity of adverse effects can be increased when Ginkgo biloba is combined with Bethanechol.
Neostigmine The risk or severity of adverse effects can be increased when Neostigmine is combined with Bethanechol.
Bambuterol The risk or severity of adverse effects can be increased when Bambuterol is combined with Bethanechol.
1,10-Phenanthroline The risk or severity of adverse effects can be increased when 1,10-Phenanthroline is combined with Bethanechol.
Thiotepa The risk or severity of adverse effects can be increased when Thiotepa is combined with Bethanechol.
Huperzine A The risk or severity of adverse effects can be increased when Huperzine A is combined with Bethanechol.
Phenserine The risk or severity of adverse effects can be increased when Phenserine is combined with Bethanechol.
Regramostim The risk or severity of adverse effects can be increased when Regramostim is combined with Bethanechol.
Aprotinin The risk or severity of adverse effects can be increased when Aprotinin is combined with Bethanechol.
Betaine The risk or severity of adverse effects can be increased when Betaine is combined with Bethanechol.
Capsaicin The risk or severity of adverse effects can be increased when Capsaicin is combined with Bethanechol.
Coumaphos The risk or severity of adverse effects can be increased when Coumaphos is combined with Bethanechol.
Dichlorvos The risk or severity of adverse effects can be increased when Dichlorvos is combined with Bethanechol.
Fenthion The risk or severity of adverse effects can be increased when Fenthion is combined with Bethanechol.
Metrifonate The risk or severity of adverse effects can be increased when Metrifonate is combined with Bethanechol.
Acotiamide The risk or severity of adverse effects can be increased when Acotiamide is combined with Bethanechol.
Methanesulfonyl Fluoride The risk or severity of adverse effects can be increased when Methanesulfonyl Fluoride is combined with Bethanechol.
Paraoxon The risk or severity of adverse effects can be increased when Paraoxon is combined with Bethanechol.
Tyrothricin The risk or severity of adverse effects can be increased when Tyrothricin is combined with Bethanechol.
Ipidacrine The risk or severity of adverse effects can be increased when Ipidacrine is combined with Bethanechol.
Distigmine The risk or severity of adverse effects can be increased when Distigmine is combined with Bethanechol.
Tretamine The risk or severity of adverse effects can be increased when Tretamine is combined with Bethanechol.
Posiphen The risk or severity of adverse effects can be increased when Posiphen is combined with Bethanechol.
Methylphosphinic Acid The risk or severity of adverse effects can be increased when Methylphosphinic Acid is combined with Bethanechol.
Capreomycin The therapeutic efficacy of Bethanechol can be decreased when used in combination with Capreomycin.
Framycetin The therapeutic efficacy of Bethanechol can be decreased when used in combination with Framycetin.
Amikacin The therapeutic efficacy of Bethanechol can be decreased when used in combination with Amikacin.
Tobramycin The therapeutic efficacy of Bethanechol can be decreased when used in combination with Tobramycin.
Gentamicin The therapeutic efficacy of Bethanechol can be decreased when used in combination with Gentamicin.
Netilmicin The therapeutic efficacy of Bethanechol can be decreased when used in combination with Netilmicin.

Target Protein

Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M5 CHRM5
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M4 CHRM4

Referensi & Sumber

Synthesis reference: Major, R.T. and Bonnett, H.T.; U.S. Patent 2,322,375: June 22,1943; assigned to Merck & Co., Inc.
Artikel (PubMed)

Contoh Produk & Brand

Produk: 118 • International brands: 4
Produk
  • Bethanechol chloride
    Tablet • 5 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 10 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 10 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Bethanechol Chloride
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 118 produk.
International Brands
  • Duvoid — Roberts
  • Myotonachol — Glenwood
  • Myotonine
  • Uro-Carb — Hamilton

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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