Peringatan Keamanan

With drugs of this type, muscarine-like symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) often appear with overdosage (cholinergic crisis).

Edrophonium

DB01010

small molecule approved

Deskripsi

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Struktur Molekul 2D

Berat 166.2401
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Distribution half-life is 7 to 12 minutes. Elimination half-life is 33 to 110 minutes.
Volume Distribusi * 1.6±0.4 L/kg [Adults] * 2.2±1.5 L/kg [Children (0.08-10 yrs)] * 1.8±1.2 L/kg [Elderly (65-75 yrs)]
Klirens (Clearance) * 6.8 +/- 2. mL/kg/min [Adults] * 6.4 +/- 3.9 mL/kg/min [Children (0.08-10 yrs)] * 2.9 +/- 1.9 mL/kg/min [Elderly (65-75 yrs)]

Absorpsi

Rapidly absorbed.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Edrophonium is primarily renally excreted with 67% of the dose appearing in the urine. Hepatic metabolism and biliary excretion have also been demonstrated in animals

Interaksi Obat

980 Data
Digoxin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Digoxin.
Acetyldigitoxin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Acetyldigitoxin.
Deslanoside Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Deslanoside.
Ouabain Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Ouabain.
Digitoxin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Digitoxin.
Oleandrin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Oleandrin.
Cymarin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Cymarin.
Proscillaridin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Proscillaridin.
Metildigoxin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Metildigoxin.
Lanatoside C Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Lanatoside C.
Gitoformate Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Gitoformate.
Acetyldigoxin Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Acetyldigoxin.
Peruvoside Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Peruvoside.
Dipyridamole The therapeutic efficacy of Edrophonium can be decreased when used in combination with Dipyridamole.
Ephedrine Edrophonium may increase the neuromuscular blocking activities of Ephedrine.
Bambuterol Edrophonium may increase the neuromuscular blocking activities of Bambuterol.
Sar9, Met (O2)11-Substance P Edrophonium may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.
Procaine Edrophonium may increase the neuromuscular blocking activities of Procaine.
Cocaine Edrophonium may increase the neuromuscular blocking activities of Cocaine.
Trimethaphan Edrophonium may increase the neuromuscular blocking activities of Trimethaphan.
Doxacurium Edrophonium may increase the neuromuscular blocking activities of Doxacurium.
Chloroprocaine Edrophonium may increase the neuromuscular blocking activities of Chloroprocaine.
Tubocurarine Edrophonium may increase the neuromuscular blocking activities of Tubocurarine.
Aclidinium Edrophonium may increase the neuromuscular blocking activities of Aclidinium.
Propacetamol Edrophonium may increase the neuromuscular blocking activities of Propacetamol.
Clevidipine Edrophonium may increase the neuromuscular blocking activities of Clevidipine.
Mirabegron Edrophonium may increase the neuromuscular blocking activities of Mirabegron.
Moxisylyte Edrophonium may increase the neuromuscular blocking activities of Moxisylyte.
Butyrylthiocholine Edrophonium may increase the neuromuscular blocking activities of Butyrylthiocholine.
Oxybuprocaine Edrophonium may increase the neuromuscular blocking activities of Oxybuprocaine.
Benzonatate Edrophonium may increase the neuromuscular blocking activities of Benzonatate.
Succinylcholine The metabolism of Succinylcholine can be decreased when combined with Edrophonium.
Tramadol The therapeutic efficacy of Tramadol can be decreased when used in combination with Edrophonium.
Trospium The therapeutic efficacy of Trospium can be decreased when used in combination with Edrophonium.
Oxyphenonium The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Edrophonium.
Butabarbital The therapeutic efficacy of Butabarbital can be decreased when used in combination with Edrophonium.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Edrophonium.
Benzatropine The therapeutic efficacy of Benzatropine can be decreased when used in combination with Edrophonium.
Ziprasidone The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Edrophonium.
Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Edrophonium.
Talbutal The therapeutic efficacy of Talbutal can be decreased when used in combination with Edrophonium.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Edrophonium.
Amitriptyline The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Edrophonium.
Ipratropium The therapeutic efficacy of Ipratropium can be decreased when used in combination with Edrophonium.
Methadone The therapeutic efficacy of Methadone can be decreased when used in combination with Edrophonium.
Olanzapine The therapeutic efficacy of Olanzapine can be decreased when used in combination with Edrophonium.
Metixene The therapeutic efficacy of Metixene can be decreased when used in combination with Edrophonium.
Terfenadine The therapeutic efficacy of Terfenadine can be decreased when used in combination with Edrophonium.
Buclizine The therapeutic efficacy of Buclizine can be decreased when used in combination with Edrophonium.
Clozapine The therapeutic efficacy of Clozapine can be decreased when used in combination with Edrophonium.
Doxylamine The therapeutic efficacy of Doxylamine can be decreased when used in combination with Edrophonium.
Trihexyphenidyl The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Edrophonium.
Oxyphencyclimine The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Edrophonium.
Procyclidine The therapeutic efficacy of Procyclidine can be decreased when used in combination with Edrophonium.
Profenamine The therapeutic efficacy of Profenamine can be decreased when used in combination with Edrophonium.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Edrophonium.
Promazine The therapeutic efficacy of Promazine can be decreased when used in combination with Edrophonium.
Hyoscyamine The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Edrophonium.
Cyproheptadine The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Edrophonium.
Imipramine The therapeutic efficacy of Imipramine can be decreased when used in combination with Edrophonium.
Methscopolamine bromide The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Edrophonium.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Edrophonium.
Fluoxetine The therapeutic efficacy of Fluoxetine can be decreased when used in combination with Edrophonium.
Chlorpromazine The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Edrophonium.
Darifenacin The therapeutic efficacy of Darifenacin can be decreased when used in combination with Edrophonium.
Tridihexethyl The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Edrophonium.
Triflupromazine The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Edrophonium.
Dextromethorphan The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Edrophonium.
Anisotropine methylbromide The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Edrophonium.
Nortriptyline The therapeutic efficacy of Nortriptyline can be decreased when used in combination with Edrophonium.
Amoxapine The therapeutic efficacy of Amoxapine can be decreased when used in combination with Edrophonium.
Lamotrigine Lamotrigine may decrease the excretion rate of Edrophonium which could result in a higher serum level.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Edrophonium.
Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Edrophonium.
Mecamylamine The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Edrophonium.
Pirenzepine The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Edrophonium.
Paroxetine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Edrophonium.
Homatropine methylbromide The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Edrophonium.
Scopolamine The therapeutic efficacy of Scopolamine can be decreased when used in combination with Edrophonium.
Isoflurane The therapeutic efficacy of Isoflurane can be decreased when used in combination with Edrophonium.
Benzquinamide The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Edrophonium.
Clidinium The therapeutic efficacy of Clidinium can be decreased when used in combination with Edrophonium.
Propiomazine The therapeutic efficacy of Propiomazine can be decreased when used in combination with Edrophonium.
Propantheline The therapeutic efficacy of Propantheline can be decreased when used in combination with Edrophonium.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Edrophonium.
Dicyclomine The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Edrophonium.
Biperiden The therapeutic efficacy of Biperiden can be decreased when used in combination with Edrophonium.
Brompheniramine The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Edrophonium.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Edrophonium.
Amantadine The therapeutic efficacy of Amantadine can be decreased when used in combination with Edrophonium.
Maprotiline The therapeutic efficacy of Maprotiline can be decreased when used in combination with Edrophonium.
Methantheline The therapeutic efficacy of Methantheline can be decreased when used in combination with Edrophonium.
Hexafluronium The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Edrophonium.
Cycrimine The therapeutic efficacy of Cycrimine can be decreased when used in combination with Edrophonium.
Desloratadine The therapeutic efficacy of Desloratadine can be decreased when used in combination with Edrophonium.
Glycopyrronium The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Edrophonium.
Tolterodine The therapeutic efficacy of Tolterodine can be decreased when used in combination with Edrophonium.
Oxybutynin The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Edrophonium.
Promethazine The therapeutic efficacy of Promethazine can be decreased when used in combination with Edrophonium.
Diphenhydramine The therapeutic efficacy of Diphenhydramine can be decreased when used in combination with Edrophonium.

Target Protein

Cholinesterase BCHE
Acetylcholinesterase ACHE

Referensi & Sumber

Synthesis reference: Terrell, R.C.; U.S. Patents 3,469,011; September 23, 1969 and 3,527,813; September 8, 1970; both assigned to Air Reduction Company, Incorporated.

Contoh Produk & Brand

Produk: 9 • International brands: 2
Produk
  • Enlon
    Injection • 10 mg/1mL • Intramuscular; Intravenous • US • Approved
  • Enlon
    Injection, solution • 10 mg/1mL • Intramuscular; Intravenous • US • Generic • Approved
  • Enlon 10mg/ml
    Liquid • 10 mg / mL • Intravenous • Canada • Approved
  • Enlon Liq IV 10mg/ml
    Liquid • 10 mg / mL • Intravenous • Canada • Approved
  • Enlon Plus
    Injection, solution • - • Intravenous • US • Approved
  • Enlon Plus
    Injection, solution • - • Intravenous • US • Approved
  • Enlon-Plus
    Injection • - • Intravenous • US • Approved
  • Enlon-Plus
    Injection • - • Intravenous • US • Approved
Menampilkan 8 dari 9 produk.
International Brands
  • Antirex — Kyorin
  • Reversol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul