Peringatan Keamanan

LD50=62.4 mg/kg (rat, oral).

Symptoms of overdose include drowsiness, vomiting and abdominal pain.


Side effects are usually mild and mainly involved the GI tract. Most common adverse GI effect is dyspepsia (11% of patients). May cause nausea, diarrhea, abdominal pain, constipation and flatulence in greater than 3% of patients.

Ketoprofen

DB01009

small molecule approved vet_approved

Deskripsi

Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Struktur Molekul 2D

Berat 254.2806
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Conventional capsules: 1.1-4 hours <p>Extended release capsules: 5.4 hours due to delayed absorption (intrinsic clearance is same as conventional capsules)</p>
Volume Distribusi -
Klirens (Clearance) * Oral-dose cl=6.9 +/- 0.8 L/h [Ketoprofen Immediate-release capsules (4 × 50 mg)] * Oral-dose cl=6.8 +/- 1.8 L/h [Ketoprofen Extended-release capsules (1 × 200 mg)] * 0.08 L/kg/h * 0.7 L/kg/h [alcoholic cirrhosis patients]

Absorpsi

Ketoprofen is rapidly and well-absorbed orally, with peak plasma levels occurring within 0.5 to 2 hours.

Metabolisme

Rapidly and extensively metabolized in the liver, primarily via conjugation to glucuronic acid. No active metabolites have been identified.

Rute Eliminasi

In a 24 hour period, approximately 80% of an administered dose of ketoprofen is excreted in the urine, primarily as the glucuronide metabolite.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

1581 Data
Amlodipine Ketoprofen may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Ketoprofen.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Ketoprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Ketoprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Ketoprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Ketoprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Ketoprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Ketoprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Ketoprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Ketoprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Ketoprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Ketoprofen.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Ketoprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Ketoprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Ketoprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Ketoprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Ketoprofen.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Ketoprofen.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Ketoprofen.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Ketoprofen.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Ketoprofen.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Ketoprofen.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Ketoprofen.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Ketoprofen.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Ketoprofen.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Ketoprofen.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Ketoprofen.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Ketoprofen.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Ketoprofen.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Ketoprofen.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Ketoprofen.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Ketoprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Ketoprofen.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Ketoprofen.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Ketoprofen.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Ketoprofen.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Ketoprofen.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Ketoprofen.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Ketoprofen.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Ketoprofen.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Ketoprofen.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Ketoprofen.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Ketoprofen.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Ketoprofen.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Ketoprofen.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ketoprofen is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Ketoprofen is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Ketoprofen is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Ketoprofen is combined with Dutasteride.
Pergolide The risk or severity of hypertension can be increased when Ketoprofen is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Ketoprofen is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Ketoprofen is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Ketoprofen is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Ketoprofen is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Ketoprofen is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Ketoprofen is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Ketoprofen is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Ketoprofen is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Ketoprofen is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Ketoprofen is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Ketoprofen is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Ketoprofen is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Ketoprofen is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Ketoprofen is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Ketoprofen is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Ketoprofen is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Ketoprofen is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Ketoprofen is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Ketoprofen is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Ketoprofen is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Ketoprofen is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Ketoprofen is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Ketoprofen is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Ketoprofen is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Ketoprofen is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Ketoprofen is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Ketoprofen is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Ketoprofen is combined with 1-benzylimidazole.
Nialamide The risk or severity of hypertension can be increased when Ketoprofen is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Ketoprofen is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Ketoprofen is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Ketoprofen is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Ketoprofen is combined with Iloperidone.
Indacaterol The risk or severity of hypertension can be increased when Ketoprofen is combined with Indacaterol.
Rotigotine The risk or severity of hypertension can be increased when Ketoprofen is combined with Rotigotine.
Amibegron The risk or severity of hypertension can be increased when Ketoprofen is combined with Amibegron.
Naluzotan The risk or severity of hypertension can be increased when Ketoprofen is combined with Naluzotan.
Cariprazine The risk or severity of hypertension can be increased when Ketoprofen is combined with Cariprazine.
Mianserin The risk or severity of hypertension can be increased when Ketoprofen is combined with Mianserin.
Pizotifen The risk or severity of hypertension can be increased when Ketoprofen is combined with Pizotifen.
Solabegron The risk or severity of hypertension can be increased when Ketoprofen is combined with Solabegron.
Asenapine The risk or severity of hypertension can be increased when Ketoprofen is combined with Asenapine.
Esmirtazapine The risk or severity of hypertension can be increased when Ketoprofen is combined with Esmirtazapine.
Vilazodone The risk or severity of hypertension can be increased when Ketoprofen is combined with Vilazodone.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1
C-X-C chemokine receptor type 1 CXCR1

Referensi & Sumber

Synthesis reference: Attilio Citterio, Daniele Fancelli, "Method of preparing ketoprofen." U.S. Patent US4845281, issued December, 1982.
Artikel (PubMed)
  • PMID: 3526298
    Kantor TG: Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy. 1986 May-Jun;6(3):93-103.
  • PMID: 16274258
    Mazieres B: Topical ketoprofen patch. Drugs R D. 2005;6(6):337-44.

Contoh Produk & Brand

Produk: 90 • International brands: 12
Produk
  • Ketophene
    Kit • 33.5 g/33.5g • Topical • US
  • Ketoprofen
    Capsule • 50 mg/1 • Oral • US • Generic • Approved
  • Ketoprofen
    Capsule • 75 mg/1 • Oral • US • Generic • Approved
  • Ketoprofen
    Capsule • 50 mg/1 • Oral • US • Generic • Approved
  • Ketoprofen
    Capsule • 75 mg/1 • Oral • US • Generic • Approved
  • Ketoprofen
    Capsule • 50 mg/1 • Oral • US • Generic • Approved
  • Ketoprofen
    Tablet • 75 mg/1 • Oral • US • Generic • Approved
  • Ketoprofen
    Capsule • 75 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 90 produk.
International Brands
  • Actron
  • Alrheumun — Teofarma
  • Capisten — Kissei
  • Epatec — Zeria Shinyaku
  • Fastum — Menarini
  • Menamin — Daiko Seiyaku
  • Orudis — Abbott
  • Orudis KT — Sanofi
  • Orugesic — Sanofi
  • Oscorel — Sanofi

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