Peringatan Keamanan

Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning,
and general irritation of the skin, and cramps.

Tioconazole

DB01007

small molecule approved

Deskripsi

Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. In addition to being an antifungal, tioconazole also has antibacterial effects on certain Gram-positive cocci bacteria.L50166

Struktur Molekul 2D

Berat 387.711
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.

Metabolisme

Orally administered tioconazole is extensively metabolized. The major metabolites are glucuronide conjugates.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

77 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Tioconazole.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Tioconazole.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tioconazole.
Colchicine The metabolism of Colchicine can be decreased when combined with Tioconazole.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Tioconazole.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Tioconazole.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Tioconazole.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Tioconazole.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Tioconazole.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Tioconazole.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Tioconazole.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Tioconazole.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Tioconazole.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Tioconazole.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Tioconazole.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Tioconazole.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Tioconazole.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Tioconazole.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Tioconazole.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Tioconazole.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Tioconazole.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Tioconazole.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Tioconazole.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Tioconazole.
Prucalopride The metabolism of Prucalopride can be decreased when combined with Tioconazole.
Acetaminophen Tioconazole may increase the hepatotoxic activities of Acetaminophen.
Propacetamol Tioconazole may increase the hepatotoxic activities of Propacetamol.
Propranolol The serum concentration of Propranolol can be increased when it is combined with Tioconazole.
Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Tioconazole.
Entrectinib The metabolism of Entrectinib can be decreased when combined with Tioconazole.
Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Tioconazole.
Elexacaftor The serum concentration of Elexacaftor can be increased when it is combined with Tioconazole.
Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tioconazole.
Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Tioconazole.
Levamlodipine The serum concentration of Levamlodipine can be increased when it is combined with Tioconazole.
Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Tioconazole.
Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Tioconazole.
Tramadol The metabolism of Tramadol can be decreased when combined with Tioconazole.
Rimegepant The metabolism of Rimegepant can be decreased when combined with Tioconazole.
Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Tioconazole.
Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Tioconazole.
Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Tioconazole.
Lurbinectedin The serum concentration of Lurbinectedin can be increased when it is combined with Tioconazole.
Oliceridine The serum concentration of Oliceridine can be increased when it is combined with Tioconazole.
Voclosporin The metabolism of Voclosporin can be decreased when combined with Tioconazole.
Silodosin The metabolism of Silodosin can be decreased when combined with Tioconazole.
Pimavanserin The metabolism of Pimavanserin can be increased when combined with Tioconazole.
Infigratinib The metabolism of Infigratinib can be decreased when combined with Tioconazole.
Finerenone The serum concentration of Finerenone can be increased when it is combined with Tioconazole.
Belzutifan The serum concentration of Belzutifan can be increased when it is combined with Tioconazole.
Daridorexant The metabolism of Daridorexant can be decreased when combined with Tioconazole.
Abrocitinib The metabolism of Abrocitinib can be decreased when combined with Tioconazole.
Mitapivat The metabolism of Mitapivat can be decreased when combined with Tioconazole.
Pacritinib The serum concentration of Pacritinib can be increased when it is combined with Tioconazole.
Cariprazine The metabolism of Cariprazine can be decreased when combined with Tioconazole.
Mavacamten The serum concentration of Mavacamten can be increased when it is combined with Tioconazole.
Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Tioconazole.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Tioconazole.
Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Tioconazole.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Tioconazole.
Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Tioconazole.
Clozapine The serum concentration of Clozapine can be increased when it is combined with Tioconazole.
Clobazam The serum concentration of Clobazam can be increased when it is combined with Tioconazole.
Elacestrant The serum concentration of Elacestrant can be increased when it is combined with Tioconazole.
Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Tioconazole.
Omaveloxolone The serum concentration of Omaveloxolone can be increased when it is combined with Tioconazole.
Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Tioconazole.
Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Tioconazole.
Palovarotene The serum concentration of Palovarotene can be increased when it is combined with Tioconazole.
Gepirone The serum concentration of Gepirone can be increased when it is combined with Tioconazole.
Etrasimod The serum concentration of Etrasimod can be increased when it is combined with Tioconazole.
Encorafenib The serum concentration of Encorafenib can be increased when it is combined with Tioconazole.
Repotrectinib The serum concentration of Repotrectinib can be increased when it is combined with Tioconazole.
Capivasertib The serum concentration of Capivasertib can be increased when it is combined with Tioconazole.
Nirogacestat The serum concentration of Nirogacestat can be increased when it is combined with Tioconazole.
Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Tioconazole.
Mavorixafor The metabolism of Mavorixafor can be decreased when combined with Tioconazole.

Target Protein

Lanosterol 14-alpha demethylase ERG11
Lanosterol 14-alpha demethylase CYP51A1

Contoh Produk & Brand

Produk: 46 • International brands: 4
Produk
  • Basic Care Tioconazole
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • Basic Care Tioconazole 1
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • CareOne Tioconazole 1
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • Dg Health Tioconazole 1
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • Equaline Tioconazole 1
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • Equate tioconazole 1 day
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • Foster and Thrive Tioconazole
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
  • Good Neighbor Pharmacy Tioconazole 1
    Ointment • 6.5 g/100g • Vaginal • US • Generic • OTC • Approved
Menampilkan 8 dari 46 produk.
International Brands
  • GyneCure
  • Monistat 1
  • Trosyd
  • Trosyl

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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