Peringatan Keamanan

Oral, mouse LD50: > 2g/kg. Intravenous, dog LD50: > 150mg/kg. Symptoms of overdose include irreversible pancytopenia, worsening GI symptoms, and acute renal failure. Suspected cancer agent.

Ganciclovir

DB01004

small molecule approved investigational

Deskripsi

An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

Struktur Molekul 2D

Berat 255.2306
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.5 to 3.6 hours (mean 2.9 hours) when administered intravenously in adults. 3.1 to 5.5 hours when administered orally in adults. Renal function impairment causes a marked increase in half life (9 to 30 hours intravenously, 15.7 to 18.2 hours orally).
Volume Distribusi * 0.74 ± 0.15 L/kg
Klirens (Clearance) * 128 +/- 63 mL/min [Patients with Renal Impairment (Clcr=50-79 mL/min)] * 57+/- 8 mL/min [Patients with Renal Impairment (Clcr=25-49 mL/min)] * 30 +/- 13 mL/min [Patients with Renal Impairment (Clcr<25 mL/min)] * 4.7+/- 2.2 mL/min/kg [pediatric patients, aged 9 months to 12 years]

Absorpsi

Poorly absorbed systemically following oral administration. Bioavailability under fasting conditions is approximately 5%, and when administered with food, 6 to 9% (about 30% with a fatty meal).

Metabolisme

Little to no metabolism, about 90% of plasma ganciclovir is eliminated unchanged in the urine.

Rute Eliminasi

Renal excretion of unchanged drug by glomerular filtration and active tubular secretion is the major route of elimination of ganciclovir.

Interaksi Makanan

1 Data
  • 1. Take with food. Food increases bioavailability.

Interaksi Obat

978 Data
Succinic acid The excretion of Succinic acid can be decreased when combined with Ganciclovir.
Citrulline The excretion of Citrulline can be decreased when combined with Ganciclovir.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Ganciclovir.
Cefdinir The excretion of Cefdinir can be decreased when combined with Ganciclovir.
Leucovorin The excretion of Leucovorin can be decreased when combined with Ganciclovir.
Fluorescein The excretion of Fluorescein can be decreased when combined with Ganciclovir.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Ganciclovir.
Quinapril The excretion of Quinapril can be decreased when combined with Ganciclovir.
Famotidine The excretion of Famotidine can be decreased when combined with Ganciclovir.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Ganciclovir.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Ganciclovir.
Tazobactam The excretion of Tazobactam can be decreased when combined with Ganciclovir.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Ganciclovir.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Ganciclovir.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Ganciclovir.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Ganciclovir.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Ganciclovir.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Ganciclovir.
Avibactam The excretion of Avibactam can be decreased when combined with Ganciclovir.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Ganciclovir.
Silibinin The excretion of Silibinin can be decreased when combined with Ganciclovir.
Relebactam The excretion of Relebactam can be decreased when combined with Ganciclovir.
Cefotiam The excretion of Cefotiam can be decreased when combined with Ganciclovir.
Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Ganciclovir.
Indomethacin The excretion of Indomethacin can be decreased when combined with Ganciclovir.
Methotrexate The excretion of Methotrexate can be decreased when combined with Ganciclovir.
Cephalexin The excretion of Cephalexin can be decreased when combined with Ganciclovir.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Ganciclovir.
Acyclovir The excretion of Acyclovir can be decreased when combined with Ganciclovir.
Cefaclor The excretion of Cefaclor can be decreased when combined with Ganciclovir.
Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Ganciclovir.
Cefazolin The excretion of Cefazolin can be decreased when combined with Ganciclovir.
Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Ganciclovir.
Cefacetrile The excretion of Cefacetrile can be decreased when combined with Ganciclovir.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Ganciclovir.
Cefaloridine The excretion of Cefaloridine can be decreased when combined with Ganciclovir.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Ganciclovir.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Ganciclovir.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Ganciclovir.
Piperacillin The excretion of Piperacillin can be decreased when combined with Ganciclovir.
Trifluridine The excretion of Trifluridine can be decreased when combined with Ganciclovir.
Allopurinol The excretion of Allopurinol can be decreased when combined with Ganciclovir.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Ganciclovir.
Tetracycline The excretion of Tetracycline can be decreased when combined with Ganciclovir.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Ganciclovir.
Doripenem The excretion of Doripenem can be decreased when combined with Ganciclovir.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Ganciclovir.
Estradiol The excretion of Estradiol can be decreased when combined with Ganciclovir.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Ganciclovir.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Ganciclovir.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Ganciclovir.
Acamprosate The excretion of Acamprosate can be decreased when combined with Ganciclovir.
Imipenem The risk or severity of generalized seizure can be increased when Ganciclovir is combined with Imipenem.
Probenecid Probenecid may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Entecavir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Entecavir.
Zidovudine The excretion of Zidovudine can be decreased when combined with Ganciclovir.
Stavudine The risk or severity of cytopenia can be increased when Ganciclovir is combined with Stavudine.
Lamivudine The risk or severity of cytopenia can be increased when Ganciclovir is combined with Lamivudine.
Didanosine The risk or severity of cytopenia can be increased when Ganciclovir is combined with Didanosine.
Zalcitabine The risk or severity of cytopenia can be increased when Ganciclovir is combined with Zalcitabine.
Abacavir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Abacavir.
Telbivudine The risk or severity of cytopenia can be increased when Ganciclovir is combined with Telbivudine.
Adefovir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Adefovir.
Tenofovir The excretion of Tenofovir can be decreased when combined with Ganciclovir.
Emtricitabine The risk or severity of cytopenia can be increased when Ganciclovir is combined with Emtricitabine.
Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Ganciclovir.
Valproic acid The excretion of Valproic acid can be decreased when combined with Ganciclovir.
Clofarabine The excretion of Clofarabine can be decreased when combined with Ganciclovir.
Icosapent Icosapent may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Ganciclovir which could result in a higher serum level.

Target Protein

DNA polymerase catalytic subunit
DNA
Thymidine kinase TK

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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