Peringatan Keamanan

Symptoms of overdose include cough, nasal congestion, nausea, sneezing and wheezing.

Cromoglicic acid

DB01003

small molecule approved

Deskripsi

A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Struktur Molekul 2D

Berat 468.3665

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.3 hours

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data

1. Take before a meal. Take cromolyn sodium 30 minutes before meals.

Interaksi Obat

2 Data

Oxymetazoline	The absorption of Cromoglicic acid can be decreased when combined with Oxymetazoline.
Methacholine	Cromoglicic acid may decrease effectiveness of Methacholine as a diagnostic agent.

Target Protein

Heat shock protein HSP 90-alpha HSP90AA1

Protein S100-P S100P

Referensi & Sumber

Synthesis reference: Margit Nagy, Lidia Fedina, Rita Balazs, Borbala Barta, Gizella Toth nee Gyarmati, Judit Marczis, Andras Szasz, "Antiasthmatic aerosol preparation of sodium cromoglycate." U.S. Patent US5753208, issued June, 1965.

Artikel (PubMed)

PMID: 8564197
Heinke S, Szucs G, Norris A, Droogmans G, Nilius B: Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8.

Link

Health Canada Product Monograph: Nalcrom (sodium cromoglycate) oral capsules

Contoh Produk & Brand

Produk: 74 • International brands: 11

Produk

Allergan Eye Itch Relief

Solution • 2 % • Ophthalmic • Canada • OTC • Approved
Anti-allergy Eye Drops

Solution • 2 % • Ophthalmic • Canada • OTC • Approved
Apo-cromolyn Nasal Spray

Spray • 2 % • Nasal • Canada • Generic • OTC • Approved
Apo-cromolyn Sterules

Solution • 1 % • Respiratory (inhalation) • Canada • Generic • Approved
Crolom

Solution / drops • 40 mg/1mL • Ophthalmic • US • Generic • Approved
Cromolyn Eye Drops

Solution • 2 % • Ophthalmic • Canada • OTC • Approved
Cromolyn Sodium

Spray, metered • 5.2 mg/1mL • Nasal • US • Generic • OTC • Approved
Cromolyn Sodium

Spray, metered • 5.2 mg/1mL • Nasal • US • Generic • OTC • Approved

Menampilkan 8 dari 74 produk.

International Brands

Aarane — Sanofi
Allergocrom — Ursapharm
Colimune — Sanofi
Cromo-Comod — Ursapharm
Cromoptic — Bausch & Lomb
Gastrofrenal — Marvecs Pharma Services
Lomudal — Sanofi
Lomusol — Sanofi
Opticron — Cooper
Rynacrom — Sanofi

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.