Peringatan Keamanan

Oral, mouse: LD50 = 1210 mg/kg; Oral, rabbit: LD50 = 172 mg/kg; Oral, rat: LD50 = 4470 mg/kg

Oxaprozin

DB00991

small molecule approved

Deskripsi

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

Struktur Molekul 2D

Berat 293.3166
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 54.9 hours
Volume Distribusi * 11 to 17 L/70 kg
Klirens (Clearance) -

Absorpsi

Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged. Antacids do not significantly affect the extent and rate of oxaprozin absorption.

Metabolisme

Hepatic. Ester and ether glucuronide are the major conjugated metabolites of oxaprozin, and do not have significant pharmacologic activity.

Rute Eliminasi

Oxaprozin is expected to be excreted in human milk based on its physical-chemical properties; however, the amount of oxaprozin excreted in breast milk has not been evaluated. Approximately 95% of oxaprozin is metabolized by the liver. Approximately 5% of the oxaprozin dose is excreted unchanged in the urine. Sixty-five percent (65%) of the dose is excreted in the urine and 35% in the feces as metabolite. Biliary excretion of unchanged oxaprozin is a minor pathway. Several oxaprozin metabolites have been identified in human urine or feces.

Interaksi Makanan

1 Data
  • 1. Take with food. Take once daily after breakfast. Food decreases the rate but not the extent of absorption.

Interaksi Obat

1412 Data
Amlodipine Oxaprozin may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Oxaprozin.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Oxaprozin.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Oxaprozin.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Oxaprozin.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Oxaprozin.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Oxaprozin.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Oxaprozin.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Oxaprozin.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Oxaprozin.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Oxaprozin.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Oxaprozin.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Oxaprozin.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Oxaprozin.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Oxaprozin.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Oxaprozin.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Oxaprozin.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Oxaprozin.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Oxaprozin.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Oxaprozin.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Oxaprozin.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Oxaprozin.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Oxaprozin.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Oxaprozin.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Oxaprozin.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Oxaprozin.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Oxaprozin.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Oxaprozin.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Oxaprozin.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Oxaprozin.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Oxaprozin.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Oxaprozin.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Oxaprozin.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Oxaprozin.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Oxaprozin.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Oxaprozin.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Oxaprozin.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Oxaprozin.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Oxaprozin.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Oxaprozin.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Oxaprozin.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Oxaprozin.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Oxaprozin.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Oxaprozin.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Oxaprozin.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Oxaprozin.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Oxaprozin.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Oxaprozin.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Oxaprozin.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Oxaprozin.
Frovatriptan The risk or severity of hypertension can be increased when Oxaprozin is combined with Frovatriptan.
Methoxyflurane The risk or severity of hypertension can be increased when Oxaprozin is combined with Methoxyflurane.
Selegiline The risk or severity of hypertension can be increased when Oxaprozin is combined with Selegiline.
Ergoloid mesylate The risk or severity of hypertension can be increased when Oxaprozin is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Oxaprozin is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Oxaprozin is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Oxaprozin is combined with Dutasteride.
Halothane The risk or severity of hypertension can be increased when Oxaprozin is combined with Halothane.
Moclobemide The risk or severity of hypertension can be increased when Oxaprozin is combined with Moclobemide.
Pergolide The risk or severity of hypertension can be increased when Oxaprozin is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Oxaprozin is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Oxaprozin is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Oxaprozin is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Oxaprozin is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Oxaprozin is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Oxaprozin is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Oxaprozin is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Oxaprozin is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Oxaprozin is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Oxaprozin is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Oxaprozin is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Oxaprozin is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Oxaprozin is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Oxaprozin is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Oxaprozin is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Oxaprozin is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Oxaprozin is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Oxaprozin is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Oxaprozin is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Oxaprozin is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Oxaprozin is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Oxaprozin is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Oxaprozin is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Oxaprozin is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Oxaprozin is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Oxaprozin is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Oxaprozin is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Oxaprozin is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Oxaprozin is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Oxaprozin is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Oxaprozin is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Oxaprozin is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Oxaprozin is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Oxaprozin is combined with Iloperidone.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Synthesis reference: Zhou XP, Zhang MX, Sun W, Yang XH, Wang GS, Sui DY, Yu XF, Qu SC: Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug. Biol Pharm Bull. 2009 Dec;32(12):1986-90. Pubmed(http://www.ncbi.nlm.nih.gov/pubmed/19952416).
Artikel (PubMed)
  • PMID: 15324531
    Heller B, Tarricone R: Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004 Aug;20(8):1279-90.

Contoh Produk & Brand

Produk: 52 • International brands: 6
Produk
  • Apo-oxaprozin
    Tablet • 600 mg • Oral • Canada • Generic • Approved
  • Coxanto
    Capsule • 300 mg/1 • Oral • US • Approved
  • Daypro
    Tablet, film coated • 600 mg/1 • Oral • US • Approved
  • Daypro
    Tablet, film coated • 600 mg/1 • Oral • US • Approved
  • Daypro
    Tablet, film coated • 600 mg/1 • Oral • US • Approved
  • Daypro
    Tablet • 600 mg • Oral • Canada • Approved
  • Daypro Alta
    Tablet, film coated • 600 mg/1 • Oral • US • Approved
  • Oxaprozin
    Tablet • 600 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 52 produk.
International Brands
  • Alvo
  • Danoprox
  • Dayrun
  • Deflam
  • Duraprox
  • Walix

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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