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Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Diethylstilbestrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Diethylstilbestrol. |
| Chlorotrianisene | The therapeutic efficacy of Exemestane can be decreased when used in combination with Chlorotrianisene. |
| Conjugated estrogens | The therapeutic efficacy of Exemestane can be decreased when used in combination with Conjugated estrogens. |
| Estrone | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estrone. |
| Estradiol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estradiol. |
| Dienestrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Dienestrol. |
| Ethinylestradiol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Ethinylestradiol. |
| Mestranol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Mestranol. |
| Estriol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estriol. |
| Estrone sulfate | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estrone sulfate. |
| Quinestrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Quinestrol. |
| Hexestrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Hexestrol. |
| Tibolone | The therapeutic efficacy of Exemestane can be decreased when used in combination with Tibolone. |
| Synthetic Conjugated Estrogens, A | The therapeutic efficacy of Exemestane can be decreased when used in combination with Synthetic Conjugated Estrogens, A. |
| Synthetic Conjugated Estrogens, B | The therapeutic efficacy of Exemestane can be decreased when used in combination with Synthetic Conjugated Estrogens, B. |
| Polyestradiol phosphate | The therapeutic efficacy of Exemestane can be decreased when used in combination with Polyestradiol phosphate. |
| Esterified estrogens | The therapeutic efficacy of Exemestane can be decreased when used in combination with Esterified estrogens. |
| Zeranol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Zeranol. |
| Equol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Equol. |
| Promestriene | The therapeutic efficacy of Exemestane can be decreased when used in combination with Promestriene. |
| Methallenestril | The therapeutic efficacy of Exemestane can be decreased when used in combination with Methallenestril. |
| Epimestrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Epimestrol. |
| Moxestrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Moxestrol. |
| Estradiol acetate | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estradiol acetate. |
| Estradiol benzoate | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estradiol benzoate. |
| Estradiol cypionate | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estradiol cypionate. |
| Estradiol valerate | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estradiol valerate. |
| Biochanin A | The therapeutic efficacy of Exemestane can be decreased when used in combination with Biochanin A. |
| Formononetin | The therapeutic efficacy of Exemestane can be decreased when used in combination with Formononetin. |
| Estetrol | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estetrol. |
| Methadone | The serum concentration of Methadone can be increased when it is combined with Exemestane. |
| Pitolisant | The serum concentration of Exemestane can be decreased when it is combined with Pitolisant. |
| Metreleptin | The metabolism of Exemestane can be increased when combined with Metreleptin. |
| Cenobamate | The serum concentration of Exemestane can be decreased when it is combined with Cenobamate. |
| Ritonavir | The serum concentration of Exemestane can be increased when it is combined with Ritonavir. |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Exemestane. |
| Tucatinib | The metabolism of Tucatinib can be decreased when combined with Exemestane. |
| Abametapir | The serum concentration of Exemestane can be increased when it is combined with Abametapir. |
| Satralizumab | The serum concentration of Exemestane can be decreased when it is combined with Satralizumab. |
| Sotorasib | The serum concentration of Exemestane can be decreased when it is combined with Sotorasib. |
| Cyclosporine | The metabolism of Exemestane can be decreased when combined with Cyclosporine. |
| Fluvoxamine | The metabolism of Exemestane can be decreased when combined with Fluvoxamine. |
| Fluconazole | The metabolism of Exemestane can be decreased when combined with Fluconazole. |
| Erythromycin | The serum concentration of Exemestane can be increased when it is combined with Erythromycin. |
| Ziprasidone | The metabolism of Exemestane can be decreased when combined with Ziprasidone. |
| Isradipine | The metabolism of Exemestane can be decreased when combined with Isradipine. |
| Diltiazem | The metabolism of Exemestane can be decreased when combined with Diltiazem. |
| Clozapine | The metabolism of Exemestane can be decreased when combined with Clozapine. |
| Ciprofloxacin | The metabolism of Exemestane can be decreased when combined with Ciprofloxacin. |
| Nicardipine | The metabolism of Exemestane can be decreased when combined with Nicardipine. |
| Verapamil | The metabolism of Exemestane can be decreased when combined with Verapamil. |
| Aprepitant | The metabolism of Exemestane can be decreased when combined with Aprepitant. |
| Isoniazid | The metabolism of Exemestane can be decreased when combined with Isoniazid. |
| Primaquine | The metabolism of Exemestane can be decreased when combined with Primaquine. |
| Miconazole | The metabolism of Exemestane can be decreased when combined with Miconazole. |
| Fusidic acid | The metabolism of Exemestane can be decreased when combined with Fusidic acid. |
| Zimelidine | The metabolism of Exemestane can be decreased when combined with Zimelidine. |
| Dronedarone | The metabolism of Exemestane can be decreased when combined with Dronedarone. |
| Milnacipran | The metabolism of Exemestane can be decreased when combined with Milnacipran. |
| Simeprevir | The metabolism of Exemestane can be decreased when combined with Simeprevir. |
| Isavuconazonium | The metabolism of Exemestane can be decreased when combined with Isavuconazonium. |
| Desvenlafaxine | The metabolism of Exemestane can be decreased when combined with Desvenlafaxine. |
| Nilvadipine | The metabolism of Exemestane can be decreased when combined with Nilvadipine. |
| Seproxetine | The metabolism of Exemestane can be decreased when combined with Seproxetine. |
| Linagliptin | The metabolism of Exemestane can be decreased when combined with Linagliptin. |
| Indalpine | The metabolism of Exemestane can be decreased when combined with Indalpine. |
| Netupitant | The metabolism of Exemestane can be decreased when combined with Netupitant. |
| Barnidipine | The metabolism of Exemestane can be decreased when combined with Barnidipine. |
| Benidipine | The metabolism of Exemestane can be decreased when combined with Benidipine. |
| Venetoclax | The metabolism of Exemestane can be decreased when combined with Venetoclax. |
| Isavuconazole | The metabolism of Exemestane can be decreased when combined with Isavuconazole. |
| Fosnetupitant | The metabolism of Exemestane can be decreased when combined with Fosnetupitant. |
| Berotralstat | The metabolism of Exemestane can be decreased when combined with Berotralstat. |
| Voriconazole | The metabolism of Exemestane can be decreased when combined with Voriconazole. |
| Danazol | The metabolism of Exemestane can be decreased when combined with Danazol. |
| Nelfinavir | The metabolism of Exemestane can be decreased when combined with Nelfinavir. |
| Indinavir | The metabolism of Exemestane can be decreased when combined with Indinavir. |
| Terfenadine | The metabolism of Exemestane can be decreased when combined with Terfenadine. |
| Efavirenz | The metabolism of Exemestane can be decreased when combined with Efavirenz. |
| Ergotamine | The metabolism of Exemestane can be decreased when combined with Ergotamine. |
| Amprenavir | The metabolism of Exemestane can be decreased when combined with Amprenavir. |
| Delavirdine | The metabolism of Exemestane can be decreased when combined with Delavirdine. |
| Methimazole | The metabolism of Exemestane can be decreased when combined with Methimazole. |
| Conivaptan | The metabolism of Exemestane can be decreased when combined with Conivaptan. |
| Tipranavir | The metabolism of Exemestane can be decreased when combined with Tipranavir. |
| Telithromycin | The metabolism of Exemestane can be decreased when combined with Telithromycin. |
| Ketoconazole | The metabolism of Exemestane can be decreased when combined with Ketoconazole. |
| Atazanavir | The metabolism of Exemestane can be decreased when combined with Atazanavir. |
| Amiodarone | The metabolism of Exemestane can be decreased when combined with Amiodarone. |
| Nefazodone | The metabolism of Exemestane can be decreased when combined with Nefazodone. |
| Itraconazole | The metabolism of Exemestane can be decreased when combined with Itraconazole. |
| Clarithromycin | The metabolism of Exemestane can be decreased when combined with Clarithromycin. |
| Saquinavir | The metabolism of Exemestane can be decreased when combined with Saquinavir. |
| Posaconazole | The metabolism of Exemestane can be decreased when combined with Posaconazole. |
| Darunavir | The metabolism of Exemestane can be decreased when combined with Darunavir. |
| Lopinavir | The metabolism of Exemestane can be decreased when combined with Lopinavir. |
| Ditiocarb | The metabolism of Exemestane can be decreased when combined with Ditiocarb. |
| Nilotinib | The metabolism of Exemestane can be decreased when combined with Nilotinib. |
| Telaprevir | The metabolism of Exemestane can be decreased when combined with Telaprevir. |
| Lonafarnib | The metabolism of Exemestane can be decreased when combined with Lonafarnib. |