Peringatan Keamanan

LD50 oral mice = 1460 mg/kg, LD50 oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

Dopamine

DB00988

small molecule approved

Deskripsi

One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.

Struktur Molekul 2D

Berat 153.1784
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Dopamine is rapidly absorbed from the small intestine.

Metabolisme

Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA).

Rute Eliminasi

It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged.

Interaksi Obat

1296 Data
Hyaluronidase (ovine) The risk or severity of adverse effects can be increased when Hyaluronidase (ovine) is combined with Dopamine.
Hyaluronidase (human recombinant) The risk or severity of adverse effects can be increased when Hyaluronidase (human recombinant) is combined with Dopamine.
Hyaluronidase The risk or severity of adverse effects can be increased when Hyaluronidase is combined with Dopamine.
Valsartan Dopamine may decrease the antihypertensive activities of Valsartan.
Ramipril Dopamine may decrease the antihypertensive activities of Ramipril.
Esmolol Dopamine may decrease the antihypertensive activities of Esmolol.
Betaxolol Dopamine may decrease the antihypertensive activities of Betaxolol.
Remikiren Dopamine may decrease the antihypertensive activities of Remikiren.
Guanadrel Dopamine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Dopamine may decrease the antihypertensive activities of Olmesartan.
Atenolol Dopamine may decrease the antihypertensive activities of Atenolol.
Diltiazem Dopamine may decrease the antihypertensive activities of Diltiazem.
Minoxidil Dopamine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Dopamine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Dopamine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Dopamine may decrease the antihypertensive activities of Nimodipine.
Trandolapril Dopamine may decrease the antihypertensive activities of Trandolapril.
Lercanidipine Dopamine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Dopamine may decrease the antihypertensive activities of Benazepril.
Bosentan Dopamine may decrease the antihypertensive activities of Bosentan.
Enalapril Dopamine may decrease the antihypertensive activities of Enalapril.
Candoxatril Dopamine may decrease the antihypertensive activities of Candoxatril.
Nicardipine Dopamine may decrease the antihypertensive activities of Nicardipine.
Losartan Dopamine may decrease the antihypertensive activities of Losartan.
Moexipril Dopamine may decrease the antihypertensive activities of Moexipril.
Nitroglycerin Dopamine may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Dopamine may decrease the antihypertensive activities of Metyrosine.
Cryptenamine Dopamine may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Dopamine may decrease the antihypertensive activities of Candesartan cilexetil.
Alprenolol Dopamine may decrease the antihypertensive activities of Alprenolol.
Eprosartan Dopamine may decrease the antihypertensive activities of Eprosartan.
Quinapril Dopamine may decrease the antihypertensive activities of Quinapril.
Telmisartan Dopamine may decrease the antihypertensive activities of Telmisartan.
Felodipine Dopamine may decrease the antihypertensive activities of Felodipine.
Irbesartan Dopamine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Dopamine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Dopamine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Dopamine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Dopamine may decrease the antihypertensive activities of Trimethaphan.
Carvedilol Dopamine may decrease the antihypertensive activities of Carvedilol.
Bretylium Dopamine may decrease the antihypertensive activities of Bretylium.
Terazosin Dopamine may decrease the antihypertensive activities of Terazosin.
Captopril Dopamine may decrease the antihypertensive activities of Captopril.
Bepridil Dopamine may decrease the antihypertensive activities of Bepridil.
Bevantolol Dopamine may decrease the antihypertensive activities of Bevantolol.
Practolol Dopamine may decrease the antihypertensive activities of Practolol.
Cilazapril Dopamine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Dopamine may decrease the antihypertensive activities of Saprisartan.
Spirapril Dopamine may decrease the antihypertensive activities of Spirapril.
Mibefradil Dopamine may decrease the antihypertensive activities of Mibefradil.
Dexpropranolol Dopamine may decrease the antihypertensive activities of Dexpropranolol.
Debrisoquine Dopamine may decrease the antihypertensive activities of Debrisoquine.
Nebivolol Dopamine may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Dopamine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Dopamine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Dopamine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Dopamine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Dopamine may decrease the antihypertensive activities of Pinacidil.
Bupranolol Dopamine may decrease the antihypertensive activities of Bupranolol.
Temocapril Dopamine may decrease the antihypertensive activities of Temocapril.
Riociguat Dopamine may decrease the antihypertensive activities of Riociguat.
Indenolol Dopamine may decrease the antihypertensive activities of Indenolol.
Hexamethonium Dopamine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Dopamine may decrease the antihypertensive activities of Aliskiren.
Trimazosin Dopamine may decrease the antihypertensive activities of Trimazosin.
Lacidipine Dopamine may decrease the antihypertensive activities of Lacidipine.
Manidipine Dopamine may decrease the antihypertensive activities of Manidipine.
Niguldipine Dopamine may decrease the antihypertensive activities of Niguldipine.
Rauwolfia serpentina root Dopamine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Selexipag Dopamine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Dopamine may decrease the antihypertensive activities of Angiotensin 1-7.
Talinolol Dopamine may decrease the antihypertensive activities of Talinolol.
Imidapril Dopamine may decrease the antihypertensive activities of Imidapril.
BQ-123 Dopamine may decrease the antihypertensive activities of BQ-123.
Tetrahydropalmatine Dopamine may decrease the antihypertensive activities of Tetrahydropalmatine.
Landiolol Dopamine may decrease the antihypertensive activities of Landiolol.
Dihydralazine Dopamine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Dopamine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Dopamine may decrease the antihypertensive activities of Guanoxan.
Delapril Dopamine may decrease the antihypertensive activities of Delapril.
Vincamine Dopamine may decrease the antihypertensive activities of Vincamine.
Linsidomine Dopamine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Dopamine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Dopamine may decrease the antihypertensive activities of Tolonidine.
Endralazine Dopamine may decrease the antihypertensive activities of Endralazine.
Esatenolol Dopamine may decrease the antihypertensive activities of Esatenolol.
Cadralazine Dopamine may decrease the antihypertensive activities of Cadralazine.
Cloranolol Dopamine may decrease the antihypertensive activities of Cloranolol.
Bietaserpine Dopamine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Dopamine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Dopamine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Dopamine may decrease the antihypertensive activities of Guanoclor.
Candesartan Dopamine may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Dopamine may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Dopamine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Dopamine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Dopamine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Dopamine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Dopamine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Dopamine may decrease the antihypertensive activities of Quinaprilat.

Target Protein

D(2) dopamine receptor DRD2
D(1A) dopamine receptor DRD1
D(1B) dopamine receptor DRD5
D(3) dopamine receptor DRD3
D(4) dopamine receptor DRD4
Sodium-dependent dopamine transporter SLC6A3
Dopamine beta-hydroxylase DBH
5-hydroxytryptamine receptor 1A HTR1A
5-hydroxytryptamine receptor 7 HTR7
D(1) dopamine receptor DRD1
Sodium-dependent noradrenaline transporter SLC6A2
Sodium-dependent serotonin transporter SLC6A4
5-hydroxytryptamine receptor 3A HTR3A
5-hydroxytryptamine receptor 3B HTR3B
Superoxide dismutase [Cu-Zn] SOD1
Synaptic vesicular amine transporter SLC18A2

Referensi & Sumber

Synthesis reference: Klaus Schoellkopf, Rudolf Albrecht, Manfred Lehmann, Gertrud Schroeder, "Novel dopamine derivatives, processes for their preparation, and their use as medicinal agents." U.S. Patent US4958026, issued February, 1972.
Artikel (PubMed)
  • PMID: 17237217
    Barron AB, Maleszka R, Vander Meer RK, Robinson GE: Octopamine modulates honey bee dance behavior. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1703-7. Epub 2007 Jan 19.
  • PMID: 11805404
    Giuliano F, Allard J: Dopamine and male sexual function. Eur Urol. 2001 Dec;40(6):601-8.
  • PMID: 11477488
    Giuliano F, Allard J: Dopamine and sexual function. Int J Impot Res. 2001 Aug;13 Suppl 3:S18-28.
  • PMID: 9858756
    Berridge KC, Robinson TE: What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev. 1998 Dec;28(3):309-69.
  • PMID: 14561867
    Pecina S, Cagniard B, Berridge KC, Aldridge JW, Zhuang X: Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards. J Neurosci. 2003 Oct 15;23(28):9395-402.

Contoh Produk & Brand

Produk: 54 • International brands: 2
Produk
  • Dopamine
    Injection, solution • 80 mg/1mL • Intravenous • US • Generic • Approved
  • Dopamine Hci
    Injection, solution, concentrate • 40 mg/1mL • Intravenous • US • Approved
  • Dopamine Hci
    Injection, solution, concentrate • 40 mg/1mL • Intravenous • US • Approved
  • Dopamine Hci In 5% Dextrose
    Injection, solution • 1.6 mg/1mL • Intravenous • US • Approved
  • Dopamine HCl
    Injection, solution • 80 mg/1mL • Intravenous • US • Generic • Approved
  • Dopamine HCl
    Injection, solution • 160 mg/1mL • Intravenous • US • Generic • Approved
  • Dopamine HCl
    Injection, solution • 40 mg/1mL • Intravenous • US • Generic • Approved
  • Dopamine HCl
    Injection, solution • 80 mg/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 54 produk.
International Brands
  • Intropin
  • Revimine

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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