Patients experiencing an overdose may present with vomiting, facial flushing, cheilosis, abdominal pain, headache, dizziness, and ataxia.Label These symptoms may rapidly resolve.Label Generally no treatment is required for these overdoses.A179113
The oral lowest dose causing toxic effect (TDLO) for children is 30mg/kg/21W, oral TDLO for men is 24mg/kg/4W, oral TDLO for women is 56mg/kg/8W.L6592 The intraperitoneal LD50 for rats is 901mg/kg, oral LD50 for mice is 3389mg/kg, oral LD50 for rats is >4000mg/kg.L6592
Isotretinoin is associated with major congenital malformations, spontaneous abortion, and premature birth.Label It is unknown if isotretinoin is expressed in breast milk but due to the associated hazards a decision should be made to either stop nursing or stop taking isotretinoin.Label
In animal studies, isotretinoin was associated with an increased risk of pheochromocytoma and adrenal medullary hyperplasia at doses above the recommended clinical dose.Label Isotretinoin was negative for the Ames test of mutagenicity once and weakly positive a second time.Label It has not been shown to be clastogenic.Label A study in dogs noted testicular atrophy after doses of 10-30 times the recommended clinical dose for 30 weeks.Label In trials with men there were no effects seen on sperm count, motility, morphology, ejaculate volume, and seminal plasma fructose.Label
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.Label It was most widely marketed under the brand name Accutane, which has since been discontinued.L6574 Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.L6579 The first isotretinoin-containing product was FDA approved on 7 May 1982.L6574
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Mipomersen | Isotretinoin may increase the hepatotoxic activities of Mipomersen. |
| Diethylstilbestrol | The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Isotretinoin. |
| Ethinylestradiol | The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Isotretinoin. |
| Mestranol | The therapeutic efficacy of Mestranol can be decreased when used in combination with Isotretinoin. |
| Estradiol | The therapeutic efficacy of Estradiol can be decreased when used in combination with Isotretinoin. |
| Estradiol cypionate | The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Isotretinoin. |
| Estradiol valerate | The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Isotretinoin. |
| Estetrol | The therapeutic efficacy of Estetrol can be decreased when used in combination with Isotretinoin. |
| Desogestrel | The therapeutic efficacy of Desogestrel can be decreased when used in combination with Isotretinoin. |
| Levonorgestrel | The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Isotretinoin. |
| Norethisterone | The therapeutic efficacy of Norethisterone can be decreased when used in combination with Isotretinoin. |
| Ethynodiol diacetate | The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Isotretinoin. |
| Norgestimate | The therapeutic efficacy of Norgestimate can be decreased when used in combination with Isotretinoin. |
| Drospirenone | The therapeutic efficacy of Drospirenone can be decreased when used in combination with Isotretinoin. |
| Cyproterone acetate | The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Isotretinoin. |
| Gestodene | The therapeutic efficacy of Gestodene can be decreased when used in combination with Isotretinoin. |
| Hydroxyprogesterone caproate | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Isotretinoin. |
| Norethynodrel | The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Isotretinoin. |
| Norgestrel | The therapeutic efficacy of Norgestrel can be decreased when used in combination with Isotretinoin. |
| Gestrinone | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Isotretinoin. |
| Lynestrenol | The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Isotretinoin. |
| Chlormadinone | The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Isotretinoin. |
| Norgestrienone | The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Isotretinoin. |
| Quingestanol | The therapeutic efficacy of Quingestanol can be decreased when used in combination with Isotretinoin. |
| Demegestone | The therapeutic efficacy of Demegestone can be decreased when used in combination with Isotretinoin. |
| Nomegestrol acetate | The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Isotretinoin. |
| Megestrol acetate | The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Isotretinoin. |
| Medroxyprogesterone acetate | The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Isotretinoin. |
| Dienogest | The therapeutic efficacy of Dienogest can be decreased when used in combination with Isotretinoin. |
| Ethanol | The risk or severity of adverse effects can be increased when Ethanol is combined with Isotretinoin. |
| Vitamin A | The risk or severity of adverse effects can be increased when Vitamin A is combined with Isotretinoin. |
| Pitolisant | The serum concentration of Isotretinoin can be decreased when it is combined with Pitolisant. |
| Icosapent | Icosapent may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Framycetin | Framycetin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |