Peringatan Keamanan

Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.

Lomefloxacin

DB00978

small molecule approved investigational

Deskripsi

Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.

Struktur Molekul 2D

Berat 351.3479
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8 hours
Volume Distribusi -
Klirens (Clearance) * 271 mL/min/1.73 m2 [creatinine clearance of 110 mL/min/1.73 m2] * 31 mL/min/1.73 m2 [creatinine clearance of 0 mL/min/1.73 m2]

Absorpsi

Rapid and nearly complete with approximately 95% to 98% of a single oral dose being absorbed.

Metabolisme

Minimally metabolized although 5 metabolites have been identified in human urine. 65% appears as the parent drug in urine and 9% as the glucuronide metabolite.

Rute Eliminasi

The urinary excretion of lomefloxacin was virtually complete within 72 hours after cessation of dosing, with approximately 65% of the dose being recovered as parent drug and 9% as its glucuronide metabolite.

Interaksi Makanan

2 Data
  • 1. Avoid multivalent ions. Separate the administration polyvalent ions, including magnesium and aluminum-containing antacids, from lomefloxacin by at least 4 hours before and 2 hours after lomefloxacin dosing.
  • 2. Take with or without food. The rate and extent of absorption may be reduced when lomefloxacin is taken with food.

Interaksi Obat

1023 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Lomefloxacin.
Deferasirox The serum concentration of Lomefloxacin can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Lomefloxacin can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Lomefloxacin can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Lomefloxacin can be decreased when it is combined with Teriflunomide.
Didanosine Didanosine can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Probenecid Probenecid may decrease the excretion rate of Lomefloxacin which could result in a higher serum level.
Quinapril Quinapril can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate Calcium acetate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Calcium can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric carboxymaltose Ferric carboxymaltose can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium citrate Calcium citrate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium gluconate Calcium gluconate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium polycarbophil Calcium polycarbophil can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Lomefloxacin.
Nitrofurantoin The therapeutic efficacy of Lomefloxacin can be decreased when used in combination with Nitrofurantoin.
Abiraterone The serum concentration of Lomefloxacin can be increased when it is combined with Abiraterone.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Lomefloxacin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Lomefloxacin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lomefloxacin.
Insulin human The therapeutic efficacy of Insulin human can be increased when used in combination with Lomefloxacin.
Insulin lispro The therapeutic efficacy of Insulin lispro can be increased when used in combination with Lomefloxacin.
Insulin pork The therapeutic efficacy of Insulin pork can be increased when used in combination with Lomefloxacin.
Troglitazone The therapeutic efficacy of Troglitazone can be increased when used in combination with Lomefloxacin.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Lomefloxacin.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Lomefloxacin.
Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Lomefloxacin.
Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Lomefloxacin.
Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Lomefloxacin.
Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Lomefloxacin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Lomefloxacin.
Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Lomefloxacin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Lomefloxacin.
Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Lomefloxacin.
Pentamidine The therapeutic efficacy of Pentamidine can be increased when used in combination with Lomefloxacin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Lomefloxacin.
Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Lomefloxacin.
Phenformin The therapeutic efficacy of Phenformin can be increased when used in combination with Lomefloxacin.
Sulfamethoxazole The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Lomefloxacin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Lomefloxacin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Lomefloxacin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Lomefloxacin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Lomefloxacin.
Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Lomefloxacin.
Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Lomefloxacin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Lomefloxacin.
Mitiglinide The therapeutic efficacy of Mitiglinide can be increased when used in combination with Lomefloxacin.
Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Lomefloxacin.
Sunitinib The therapeutic efficacy of Sunitinib can be increased when used in combination with Lomefloxacin.
Exenatide The therapeutic efficacy of Exenatide can be increased when used in combination with Lomefloxacin.
Mecasermin The therapeutic efficacy of Mecasermin can be increased when used in combination with Lomefloxacin.
Pramlintide The therapeutic efficacy of Pramlintide can be increased when used in combination with Lomefloxacin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Lomefloxacin.
Insulin aspart The therapeutic efficacy of Insulin aspart can be increased when used in combination with Lomefloxacin.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Lomefloxacin.
Glymidine The therapeutic efficacy of Glymidine can be increased when used in combination with Lomefloxacin.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Lomefloxacin.
Buformin The therapeutic efficacy of Buformin can be increased when used in combination with Lomefloxacin.
Vildagliptin The therapeutic efficacy of Vildagliptin can be increased when used in combination with Lomefloxacin.
Voglibose The therapeutic efficacy of Voglibose can be increased when used in combination with Lomefloxacin.
NN344 The therapeutic efficacy of NN344 can be increased when used in combination with Lomefloxacin.
AMG-222 The therapeutic efficacy of AMG-222 can be increased when used in combination with Lomefloxacin.
Bisegliptin The therapeutic efficacy of Bisegliptin can be increased when used in combination with Lomefloxacin.
Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Lomefloxacin.
Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Lomefloxacin.
Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Lomefloxacin.
Liraglutide The therapeutic efficacy of Liraglutide can be increased when used in combination with Lomefloxacin.
Gosogliptin The therapeutic efficacy of Gosogliptin can be increased when used in combination with Lomefloxacin.
Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Lomefloxacin.
Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Lomefloxacin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Lomefloxacin.
Benfluorex The therapeutic efficacy of Benfluorex can be increased when used in combination with Lomefloxacin.
Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Lomefloxacin.
Albiglutide The therapeutic efficacy of Albiglutide can be increased when used in combination with Lomefloxacin.
Dulaglutide The therapeutic efficacy of Dulaglutide can be increased when used in combination with Lomefloxacin.
Lobeglitazone The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Lomefloxacin.
Netoglitazone The therapeutic efficacy of Netoglitazone can be increased when used in combination with Lomefloxacin.
Rivoglitazone The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Lomefloxacin.
Ciglitazone The therapeutic efficacy of Ciglitazone can be increased when used in combination with Lomefloxacin.
Lixisenatide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Lomefloxacin.
Insulin beef The therapeutic efficacy of Insulin beef can be increased when used in combination with Lomefloxacin.
Insulin degludec The therapeutic efficacy of Insulin degludec can be increased when used in combination with Lomefloxacin.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be increased when used in combination with Lomefloxacin.
Insulin tregopil The therapeutic efficacy of Insulin tregopil can be increased when used in combination with Lomefloxacin.
Ipragliflozin The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Lomefloxacin.
Dutogliptin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Lomefloxacin.
Allicin The therapeutic efficacy of Allicin can be increased when used in combination with Lomefloxacin.
Tofogliflozin The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Lomefloxacin.

Target Protein

DNA gyrase subunit A gyrA
DNA topoisomerase 2-beta TOP2B
DNA topoisomerase 4 subunit A parC
DNA topoisomerase 2-alpha TOP2A

Referensi & Sumber

Contoh Produk & Brand

Produk: 1 • International brands: 1
Produk
  • Maxaquin
    Tablet, film coated • 400 mg/1 • Oral • US • Approved
International Brands
  • Bareon

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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