Bromfenac

DB00963

small molecule approved withdrawn

Deskripsi

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.L43942,T239

Struktur Molekul 2D

Berat 334.165
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The plasma concentration of bromfenac following ocular administration in humans is unknown.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

155 Data
Aminosalicylic acid The therapeutic efficacy of Aminosalicylic acid can be decreased when used in combination with Bromfenac.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Bromfenac.
Sulfasalazine The therapeutic efficacy of Sulfasalazine can be decreased when used in combination with Bromfenac.
Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Bromfenac.
Acetylsalicylic acid The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Bromfenac.
Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Bromfenac.
Olsalazine The risk or severity of nephrotoxicity can be increased when Bromfenac is combined with Olsalazine.
Bismuth subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Bromfenac.
Dersalazine The therapeutic efficacy of Dersalazine can be decreased when used in combination with Bromfenac.
Phenyl aminosalicylate The therapeutic efficacy of Phenyl aminosalicylate can be decreased when used in combination with Bromfenac.
Methyl salicylate The therapeutic efficacy of Methyl salicylate can be decreased when used in combination with Bromfenac.
Trolamine salicylate The therapeutic efficacy of Trolamine salicylate can be decreased when used in combination with Bromfenac.
Nitroaspirin The therapeutic efficacy of Nitroaspirin can be decreased when used in combination with Bromfenac.
Aloxiprin The therapeutic efficacy of Aloxiprin can be decreased when used in combination with Bromfenac.
Guacetisal The therapeutic efficacy of Guacetisal can be decreased when used in combination with Bromfenac.
Carbaspirin calcium The therapeutic efficacy of Carbaspirin calcium can be decreased when used in combination with Bromfenac.
Choline salicylate The therapeutic efficacy of Choline salicylate can be decreased when used in combination with Bromfenac.
Thiosalicylic acid The therapeutic efficacy of Thiosalicylic acid can be decreased when used in combination with Bromfenac.
Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Bromfenac.
Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Bromfenac.
Nepafenac The risk or severity of adverse effects can be increased when Bromfenac is combined with Nepafenac.
Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Bromfenac.
Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Bromfenac.
Tenoxicam The risk or severity of adverse effects can be increased when Tenoxicam is combined with Bromfenac.
Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Bromfenac.
Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Bromfenac.
Rofecoxib The risk or severity of adverse effects can be increased when Rofecoxib is combined with Bromfenac.
Piroxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Bromfenac.
Fenoprofen The risk or severity of adverse effects can be increased when Fenoprofen is combined with Bromfenac.
Valdecoxib The risk or severity of adverse effects can be increased when Valdecoxib is combined with Bromfenac.
Sulindac The risk or severity of adverse effects can be increased when Sulindac is combined with Bromfenac.
Etodolac The risk or severity of adverse effects can be increased when Etodolac is combined with Bromfenac.
Mefenamic acid The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Bromfenac.
Naproxen The risk or severity of adverse effects can be increased when Naproxen is combined with Bromfenac.
Phenylbutazone The risk or severity of adverse effects can be increased when Phenylbutazone is combined with Bromfenac.
Meloxicam The risk or severity of adverse effects can be increased when Meloxicam is combined with Bromfenac.
Carprofen The risk or severity of adverse effects can be increased when Carprofen is combined with Bromfenac.
Suprofen The risk or severity of adverse effects can be increased when Suprofen is combined with Bromfenac.
Salicylic acid The risk or severity of adverse effects can be increased when Salicylic acid is combined with Bromfenac.
Meclofenamic acid The risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Bromfenac.
Oxaprozin The risk or severity of adverse effects can be increased when Bromfenac is combined with Oxaprozin.
Ketoprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Ketoprofen.
Ibuprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Ibuprofen.
Lumiracoxib The risk or severity of adverse effects can be increased when Bromfenac is combined with Lumiracoxib.
Magnesium salicylate The risk or severity of adverse effects can be increased when Bromfenac is combined with Magnesium salicylate.
Salsalate The risk or severity of adverse effects can be increased when Bromfenac is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of adverse effects can be increased when Bromfenac is combined with Choline magnesium trisalicylate.
Antipyrine The risk or severity of adverse effects can be increased when Bromfenac is combined with Antipyrine.
Tiaprofenic acid The risk or severity of adverse effects can be increased when Bromfenac is combined with Tiaprofenic acid.
Etoricoxib The risk or severity of adverse effects can be increased when Bromfenac is combined with Etoricoxib.
Oxyphenbutazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Oxyphenbutazone.
Niflumic acid The risk or severity of adverse effects can be increased when Bromfenac is combined with Niflumic acid.
Nimesulide The risk or severity of adverse effects can be increased when Bromfenac is combined with Nimesulide.
Benoxaprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Benoxaprofen.
Zomepirac The risk or severity of adverse effects can be increased when Bromfenac is combined with Zomepirac.
Lornoxicam The risk or severity of adverse effects can be increased when Bromfenac is combined with Lornoxicam.
Aceclofenac The risk or severity of adverse effects can be increased when Bromfenac is combined with Aceclofenac.
Zaltoprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Zaltoprofen.
Azapropazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Azapropazone.
Felbinac The risk or severity of adverse effects can be increased when Bromfenac is combined with Felbinac.
Parecoxib The risk or severity of adverse effects can be increased when Bromfenac is combined with Parecoxib.
Salicylamide The risk or severity of adverse effects can be increased when Bromfenac is combined with Salicylamide.
Kebuzone The risk or severity of adverse effects can be increased when Bromfenac is combined with Kebuzone.
Isoxicam The risk or severity of adverse effects can be increased when Bromfenac is combined with Isoxicam.
Indoprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Indoprofen.
Ibuproxam The risk or severity of adverse effects can be increased when Bromfenac is combined with Ibuproxam.
Floctafenine The risk or severity of adverse effects can be increased when Bromfenac is combined with Floctafenine.
Fenbufen The risk or severity of adverse effects can be increased when Bromfenac is combined with Fenbufen.
Etofenamate The risk or severity of adverse effects can be increased when Bromfenac is combined with Etofenamate.
Epirizole The risk or severity of adverse effects can be increased when Bromfenac is combined with Epirizole.
Loxoprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Loxoprofen.
Droxicam The risk or severity of adverse effects can be increased when Bromfenac is combined with Droxicam.
Tolfenamic acid The risk or severity of adverse effects can be increased when Bromfenac is combined with Tolfenamic acid.
Clonixin The risk or severity of adverse effects can be increased when Bromfenac is combined with Clonixin.
Propacetamol The risk or severity of adverse effects can be increased when Bromfenac is combined with Propacetamol.
Tepoxalin The risk or severity of adverse effects can be increased when Bromfenac is combined with Tepoxalin.
Flunixin The risk or severity of adverse effects can be increased when Bromfenac is combined with Flunixin.
Indobufen The risk or severity of adverse effects can be increased when Bromfenac is combined with Indobufen.
Tinoridine The risk or severity of adverse effects can be increased when Bromfenac is combined with Tinoridine.
Alclofenac The risk or severity of adverse effects can be increased when Bromfenac is combined with Alclofenac.
Fentiazac The risk or severity of adverse effects can be increased when Bromfenac is combined with Fentiazac.
Suxibuzone The risk or severity of adverse effects can be increased when Bromfenac is combined with Suxibuzone.
Bumadizone The risk or severity of adverse effects can be increased when Bromfenac is combined with Bumadizone.
Alminoprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Alminoprofen.
Bufexamac The risk or severity of adverse effects can be increased when Bromfenac is combined with Bufexamac.
Feprazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Feprazone.
Difenpiramide The risk or severity of adverse effects can be increased when Bromfenac is combined with Difenpiramide.
Nifenazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Nifenazone.
Lonazolac The risk or severity of adverse effects can be increased when Bromfenac is combined with Lonazolac.
Tenidap The risk or severity of adverse effects can be increased when Bromfenac is combined with Tenidap.
Bendazac The risk or severity of adverse effects can be increased when Bromfenac is combined with Bendazac.
Pranoprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Pranoprofen.
Propyphenazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Propyphenazone.
Proglumetacin The risk or severity of adverse effects can be increased when Bromfenac is combined with Proglumetacin.
Ethenzamide The risk or severity of adverse effects can be increased when Bromfenac is combined with Ethenzamide.
Mofebutazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Mofebutazone.
Proquazone The risk or severity of adverse effects can be increased when Bromfenac is combined with Proquazone.
Benorilate The risk or severity of adverse effects can be increased when Bromfenac is combined with Benorilate.
Pirprofen The risk or severity of adverse effects can be increased when Bromfenac is combined with Pirprofen.
Acemetacin The risk or severity of adverse effects can be increased when Bromfenac is combined with Acemetacin.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Synthesis reference: Shirou Sawa, "Aqueous solution preparation containing aminoglycoside antibiotic and bromfenac." U.S. Patent US20070082857, issued April 12, 2007.
Textbook
  • Wan Po, AL. (2007). Postmarketing Surveillance. In Comprehensive Medicinal Chemistry II (pp. 755-777). Elsevier.

Contoh Produk & Brand

Produk: 43 • International brands: 1
Produk
  • Apo-bromfenac
    Solution • 0.07 % w/v • Ophthalmic • Canada • Generic • Approved
  • Auro-bromfenac
    Solution • 0.07 % w/v • Ophthalmic • Canada • Generic • Approved
  • Bromday
    Solution / drops • 0.9 mg/1mL • Ophthalmic • US • Approved
  • Bromday
    Solution / drops • 0.9 mg/1mL • Ophthalmic • US • Approved
  • Bromday
    Solution / drops • 0.9 mg/1mL • Ophthalmic • US • Approved
  • Bromday
    Solution / drops • 0.9 mg/1mL • Ophthalmic • US • Approved
  • Bromfenac
    Solution / drops • 1.035 mg/1mL • Ophthalmic • US • Generic • Approved
  • Bromfenac
    Solution / drops • 0.9 mg/1mL • Ophthalmic • US • Generic • Approved
Menampilkan 8 dari 43 produk.
International Brands
  • Duract — Wyeth-Ayerst

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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