The mean seizure dosage of mepivacaine in rhesus monkeys was found to be 18.8 mg/kg with mean arterial plasma concentration of 24.4 µg/mL. The intravenous and subcutaneous LD 50 in mice is 23 mg/kg to 35 mg/kg and 280 mg/kg respectively.
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Hydrocodone | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Magnesium sulfate | The therapeutic efficacy of Mepivacaine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Mepivacaine may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Mirtazapine | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Orphenadrine | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Pramipexole | Mepivacaine may increase the sedative activities of Pramipexole. |
| Ropinirole | Mepivacaine may increase the sedative activities of Ropinirole. |
| Rotigotine | Mepivacaine may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Mepivacaine. |
| Sodium oxybate | The risk or severity of CNS depression can be increased when Mepivacaine is combined with Sodium oxybate. |
| Suvorexant | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Thalidomide | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Esmolol | The serum concentration of Mepivacaine can be increased when it is combined with Esmolol. |
| Betaxolol | The serum concentration of Mepivacaine can be increased when it is combined with Betaxolol. |
| Metoprolol | The serum concentration of Mepivacaine can be increased when it is combined with Metoprolol. |
| Atenolol | The serum concentration of Mepivacaine can be increased when it is combined with Atenolol. |
| Timolol | The serum concentration of Mepivacaine can be increased when it is combined with Timolol. |
| Sotalol | The serum concentration of Mepivacaine can be increased when it is combined with Sotalol. |
| Propranolol | The serum concentration of Mepivacaine can be increased when it is combined with Propranolol. |
| Labetalol | The serum concentration of Mepivacaine can be increased when it is combined with Labetalol. |
| Bisoprolol | The serum concentration of Mepivacaine can be increased when it is combined with Bisoprolol. |
| Alprenolol | The serum concentration of Mepivacaine can be increased when it is combined with Alprenolol. |
| Pindolol | The serum concentration of Mepivacaine can be increased when it is combined with Pindolol. |
| Carvedilol | The serum concentration of Mepivacaine can be increased when it is combined with Carvedilol. |
| Propafenone | The serum concentration of Mepivacaine can be increased when it is combined with Propafenone. |
| Acebutolol | The serum concentration of Mepivacaine can be increased when it is combined with Acebutolol. |
| Nadolol | The serum concentration of Mepivacaine can be increased when it is combined with Nadolol. |
| Bevantolol | The serum concentration of Mepivacaine can be increased when it is combined with Bevantolol. |
| Practolol | The serum concentration of Mepivacaine can be increased when it is combined with Practolol. |
| Penbutolol | The serum concentration of Mepivacaine can be increased when it is combined with Penbutolol. |
| Oxprenolol | The serum concentration of Mepivacaine can be increased when it is combined with Oxprenolol. |
| Dexpropranolol | The serum concentration of Mepivacaine can be increased when it is combined with Dexpropranolol. |
| Celiprolol | The serum concentration of Mepivacaine can be increased when it is combined with Celiprolol. |
| Nebivolol | The serum concentration of Mepivacaine can be increased when it is combined with Nebivolol. |
| Bufuralol | The serum concentration of Mepivacaine can be increased when it is combined with Bufuralol. |
| Bopindolol | The serum concentration of Mepivacaine can be increased when it is combined with Bopindolol. |
| Bupranolol | The serum concentration of Mepivacaine can be increased when it is combined with Bupranolol. |
| Indenolol | The serum concentration of Mepivacaine can be increased when it is combined with Indenolol. |
| Arotinolol | The serum concentration of Mepivacaine can be increased when it is combined with Arotinolol. |
| Levobetaxolol | The serum concentration of Mepivacaine can be increased when it is combined with Levobetaxolol. |
| Talinolol | The serum concentration of Mepivacaine can be increased when it is combined with Talinolol. |
| Anisodamine | The serum concentration of Mepivacaine can be increased when it is combined with Anisodamine. |
| Bucindolol | The serum concentration of Mepivacaine can be increased when it is combined with Bucindolol. |
| Esatenolol | The serum concentration of Mepivacaine can be increased when it is combined with Esatenolol. |
| Cloranolol | The serum concentration of Mepivacaine can be increased when it is combined with Cloranolol. |
| Mepindolol | The serum concentration of Mepivacaine can be increased when it is combined with Mepindolol. |
| Epanolol | The serum concentration of Mepivacaine can be increased when it is combined with Epanolol. |
| Tertatolol | The serum concentration of Mepivacaine can be increased when it is combined with Tertatolol. |
| Landiolol | The serum concentration of Mepivacaine can be increased when it is combined with Landiolol. |
| Prilocaine | The risk or severity of methemoglobinemia can be increased when Mepivacaine is combined with Prilocaine. |
| Hyaluronidase (ovine) | Hyaluronidase (ovine) can cause an increase in the absorption of Mepivacaine resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Hyaluronidase (human recombinant) | Hyaluronidase (human recombinant) can cause an increase in the absorption of Mepivacaine resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Hyaluronidase | Hyaluronidase can cause an increase in the absorption of Mepivacaine resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Mepivacaine. |
| Ethanol | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Fluvoxamine. |
| Duloxetine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Duloxetine. |
| Sibutramine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Nefazodone. |
| Milnacipran | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Desvenlafaxine. |
| Levomilnacipran | Mepivacaine may decrease the excretion rate of Levomilnacipran which could result in a higher serum level. |
| Citalopram | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Citalopram. |
| Trazodone | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Sertraline. |
| Escitalopram | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Dapoxetine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Mepivacaine is combined with Alaproclate. |
| Dapsone | The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Mepivacaine. |
| Technetium Tc-99m tilmanocept | Mepivacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent. |
| Benzatropine | Benzatropine may decrease the excretion rate of Mepivacaine which could result in a higher serum level. |
| Disopyramide | Disopyramide may decrease the excretion rate of Mepivacaine which could result in a higher serum level. |
| Clozapine | The risk or severity of CNS depression can be increased when Clozapine is combined with Mepivacaine. |
| Chlorpromazine | The risk or severity of CNS depression can be increased when Chlorpromazine is combined with Mepivacaine. |
| Lamotrigine | The risk or severity of methemoglobinemia can be increased when Lamotrigine is combined with Mepivacaine. |
| Propantheline | Propantheline may decrease the excretion rate of Mepivacaine which could result in a higher serum level. |
| Dicyclomine | Dicyclomine may decrease the excretion rate of Mepivacaine which could result in a higher serum level. |
| Maprotiline | The risk or severity of CNS depression can be increased when Maprotiline is combined with Mepivacaine. |
| Tolterodine | Mepivacaine may decrease the excretion rate of Tolterodine which could result in a higher serum level. |
| Promethazine | The risk or severity of CNS depression can be increased when Mepivacaine is combined with Promethazine. |
| Doxacurium | The risk or severity of CNS depression can be increased when Mepivacaine is combined with Doxacurium. |