Peringatan Keamanan

Netilmicin has nephrotoxic and ototoxic potential. Nephrotoxicity occurs via drug accumulation in renal proximal tubular cells resulting in cellular damage. Tubular cells may regenerate despite continued exposure and nephrotoxicity is usually mild and reversible. Netilmicin is less nephrotoxic than neomycin, gentamicin, tobramycin, and amikacin, likely due to a reduced number of cationic amino groups in its structure. Otoxicity occurs as a result of irreversible damage to hair cells of the cochlea and/or summit of the ampullar cristae in the vestibular complex caused drug accumulation in the endolymph and perilymph of the inner ear. Otoxicity appears to be correlated to total exposure and may be cumulative with further doses of aminoglycosides or other ototoxic drugs (e.g. cisplatin, furosemide). High frequency hearing loss is followed by low frequency hearing loss, which may be followed by retrograde degeneration of the auditory nerve. Vestibular toxicity may cause vertigo, nausea and vomiting, dizziness and loss of balance.

Netilmicin

DB00955

small molecule approved investigational

Deskripsi

Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect of netilmiicin is not fully understood.

Struktur Molekul 2D

Berat 475.587
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.5 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and completely absorbed after IM administration, peak serum levels were achieved within 30-60 minutes. Aminoglycosides are poorly absorbed orally. Topical absorption is also poor unless severe skin damage is present.

Metabolisme

No evidence of metabolic transformation, typically 80% is recoverable in the urine within 24 hours

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

867 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Netilmicin.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Netilmicin.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Netilmicin.
Cisatracurium Netilmicin may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Netilmicin.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Netilmicin.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Netilmicin.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Netilmicin.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Netilmicin.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Netilmicin.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Netilmicin.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Netilmicin.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Netilmicin.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Netilmicin.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Netilmicin.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Netilmicin.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Netilmicin.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Netilmicin.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Netilmicin.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Netilmicin.
Carboplatin The risk or severity of ototoxicity and nephrotoxicity can be increased when Netilmicin is combined with Carboplatin.
Foscarnet The risk or severity of nephrotoxicity can be increased when Netilmicin is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Netilmicin.
Tenofovir disoproxil Netilmicin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Netilmicin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Netilmicin may increase the nephrotoxic activities of Tenofovir.
Zoledronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Zoledronic acid.
Alendronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Alendronic acid.
Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Ibandronate.
Clodronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Clodronic acid.
Risedronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Risedronic acid.
Etidronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Etidronic acid.
Incadronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Netilmicin is combined with Incadronic acid.
Taxifolin The risk or severity of nephrotoxicity can be increased when Taxifolin is combined with Netilmicin.
Licofelone The risk or severity of nephrotoxicity can be increased when Licofelone is combined with Netilmicin.
Polmacoxib The risk or severity of nephrotoxicity can be increased when Polmacoxib is combined with Netilmicin.
Ebselen The risk or severity of nephrotoxicity can be increased when Ebselen is combined with Netilmicin.
Flurbiprofen axetil The risk or severity of nephrotoxicity can be increased when Flurbiprofen axetil is combined with Netilmicin.
Acetyldigitoxin The risk or severity of adverse effects can be increased when Netilmicin is combined with Acetyldigitoxin.
Deslanoside The risk or severity of adverse effects can be increased when Netilmicin is combined with Deslanoside.
Ouabain The risk or severity of adverse effects can be increased when Netilmicin is combined with Ouabain.
Digitoxin The risk or severity of adverse effects can be increased when Netilmicin is combined with Digitoxin.
Oleandrin The risk or severity of adverse effects can be increased when Netilmicin is combined with Oleandrin.
Cymarin The risk or severity of adverse effects can be increased when Netilmicin is combined with Cymarin.
Proscillaridin The risk or severity of adverse effects can be increased when Netilmicin is combined with Proscillaridin.
Metildigoxin The risk or severity of adverse effects can be increased when Netilmicin is combined with Metildigoxin.
Lanatoside C The risk or severity of adverse effects can be increased when Netilmicin is combined with Lanatoside C.
Gitoformate The risk or severity of adverse effects can be increased when Netilmicin is combined with Gitoformate.
Acetyldigoxin The risk or severity of adverse effects can be increased when Netilmicin is combined with Acetyldigoxin.
Peruvoside The risk or severity of adverse effects can be increased when Netilmicin is combined with Peruvoside.
Torasemide The serum concentration of Netilmicin can be increased when it is combined with Torasemide.
Bumetanide The serum concentration of Netilmicin can be increased when it is combined with Bumetanide.
Etacrynic acid The serum concentration of Netilmicin can be increased when it is combined with Etacrynic acid.
Piretanide The serum concentration of Netilmicin can be increased when it is combined with Piretanide.
Azosemide The serum concentration of Netilmicin can be increased when it is combined with Azosemide.
Tripamide The serum concentration of Netilmicin can be increased when it is combined with Tripamide.
Flucloxacillin The serum concentration of Netilmicin can be decreased when it is combined with Flucloxacillin.
Phenoxymethylpenicillin The serum concentration of Netilmicin can be decreased when it is combined with Phenoxymethylpenicillin.
Dicloxacillin The serum concentration of Netilmicin can be decreased when it is combined with Dicloxacillin.
Carbenicillin The serum concentration of Netilmicin can be decreased when it is combined with Carbenicillin.
Nafcillin The serum concentration of Netilmicin can be decreased when it is combined with Nafcillin.
Hetacillin The serum concentration of Netilmicin can be decreased when it is combined with Hetacillin.
Benzylpenicilloyl polylysine The serum concentration of Netilmicin can be decreased when it is combined with Benzylpenicilloyl polylysine.
Mezlocillin The serum concentration of Netilmicin can be decreased when it is combined with Mezlocillin.
Cyclacillin The serum concentration of Netilmicin can be decreased when it is combined with Cyclacillin.
Benzylpenicillin The serum concentration of Netilmicin can be decreased when it is combined with Benzylpenicillin.
Azlocillin The serum concentration of Netilmicin can be decreased when it is combined with Azlocillin.
Cloxacillin The serum concentration of Netilmicin can be decreased when it is combined with Cloxacillin.
Amdinocillin The serum concentration of Netilmicin can be decreased when it is combined with Amdinocillin.
Bacampicillin The serum concentration of Netilmicin can be decreased when it is combined with Bacampicillin.
Meticillin The serum concentration of Netilmicin can be decreased when it is combined with Meticillin.
Pivampicillin The serum concentration of Netilmicin can be decreased when it is combined with Pivampicillin.
Pivmecillinam The serum concentration of Netilmicin can be decreased when it is combined with Pivmecillinam.
Ticarcillin The serum concentration of Netilmicin can be decreased when it is combined with Ticarcillin.
Azidocillin The serum concentration of Netilmicin can be decreased when it is combined with Azidocillin.
Carindacillin The serum concentration of Netilmicin can be decreased when it is combined with Carindacillin.
Sultamicillin The serum concentration of Netilmicin can be decreased when it is combined with Sultamicillin.
Temocillin The serum concentration of Netilmicin can be decreased when it is combined with Temocillin.
Epicillin The serum concentration of Netilmicin can be decreased when it is combined with Epicillin.
Pheneticillin The serum concentration of Netilmicin can be decreased when it is combined with Pheneticillin.
Carfecillin The serum concentration of Netilmicin can be decreased when it is combined with Carfecillin.
Propicillin The serum concentration of Netilmicin can be decreased when it is combined with Propicillin.
Clometocillin The serum concentration of Netilmicin can be decreased when it is combined with Clometocillin.
Sulbenicillin The serum concentration of Netilmicin can be decreased when it is combined with Sulbenicillin.
Penamecillin The serum concentration of Netilmicin can be decreased when it is combined with Penamecillin.
Talampicillin The serum concentration of Netilmicin can be decreased when it is combined with Talampicillin.
Aspoxicillin The serum concentration of Netilmicin can be decreased when it is combined with Aspoxicillin.
Metampicillin The serum concentration of Netilmicin can be decreased when it is combined with Metampicillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Netilmicin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Netilmicin.
Lymecycline The risk or severity of neuromuscular blockade can be increased when Lymecycline is combined with Netilmicin.
Clomocycline The risk or severity of neuromuscular blockade can be increased when Clomocycline is combined with Netilmicin.
Quinine The risk or severity of neuromuscular blockade can be increased when Quinine is combined with Netilmicin.
Tigecycline The risk or severity of neuromuscular blockade can be increased when Tigecycline is combined with Netilmicin.
Oxytetracycline The risk or severity of neuromuscular blockade can be increased when Oxytetracycline is combined with Netilmicin.
Demeclocycline The risk or severity of neuromuscular blockade can be increased when Demeclocycline is combined with Netilmicin.
Magnesium sulfate The risk or severity of neuromuscular blockade can be increased when Magnesium sulfate is combined with Netilmicin.
Metacycline The risk or severity of neuromuscular blockade can be increased when Metacycline is combined with Netilmicin.
Minocycline The risk or severity of neuromuscular blockade can be increased when Netilmicin is combined with Minocycline.
Clindamycin The risk or severity of neuromuscular blockade can be increased when Netilmicin is combined with Clindamycin.

Target Protein

30S ribosomal protein S12 rpsL
16S ribosomal RNA

Referensi & Sumber

Synthesis reference: Chou-Hong Tann, Tiruvettipuram K. Thiruvengadam, John S. Chiu, Cesar Colon, "Process for preparing netilmicin." U.S. Patent US4831123, issued June, 1966.
Artikel (PubMed)
  • PMID: 16028643
    Hemsworth S, Nunn AJ, Selwood K, Osborne C, Jones A, Pizer B: Once-daily netilmicin for neutropenic pyrexia in paediatric oncology. Acta Paediatr. 2005 Mar;94(3):268-74.
  • PMID: 15307571
    Klingenberg C, Smabrekke L, Lier T, Flaegstad T: Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis. 2004;36(6-7):474-9.
  • PMID: 15237240
    Brooks JR, Marlow N, Reeves BC, Millar MR: Use of once-daily netilmicin to treat infants with suspected sepsis in a neonatal intensive care unit. Biol Neonate. 2004;86(3):170-5. Epub 2004 Jun 29.

Contoh Produk & Brand

Produk: 4 • International brands: 1
Produk
  • Netildex
    Solution • - • Ophthalmic • Canada • Approved
  • Netildex
    Solution • - • Ophthalmic • Canada • Approved
  • Netromycin Inj 100mg/ml
    Solution • 100 mg / mL • Intramuscular; Intravenous • Canada • Approved
  • Netromycin Inj 50mg/ml
    Solution • 50 mg / mL • Intramuscular; Intravenous • Canada • Approved
International Brands
  • Netromycin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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