Peringatan Keamanan

The toxic symptoms following an overdose of a macrolide antibiotic may include nausea, vomiting, epigastric distress, and diarrhea.

Dirithromycin

DB00954

small molecule experimental

Deskripsi

Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Struktur Molekul 2D

Berat 835.086
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean plasma half-life of erythromycylamine was estimated to be about 8 h (2 to 36 h), with a mean urinary terminal elimination half-life of about 44 h (16 to 65 h) in patients with normal renal function.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Oral dirithromycin is rapidly absorbed, with an absolute bioavailability of approximately 10%. Dietary fat has little or no effect on the bioavailability of dirithromycin.

Metabolisme

Dirithromycin is converted by nonenzymatic hydrolysis during absorption to the active compound, erythromycylamine. Sixty to 90% of a dose is hydrolyzed to erythromycylamine within 35 minutes after dosing, and conversion is nearly complete after 1.5 hours. Erythromycylamine undergoes little or no hepatic biotransformation. No other metabolites of dirithromycin have been detected in the serum.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

315 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Dirithromycin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Dirithromycin.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Dirithromycin.
Buspirone The metabolism of Buspirone can be decreased when combined with Dirithromycin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Dirithromycin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Dirithromycin.
Disopyramide Dirithromycin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Dirithromycin.
Quinine The serum concentration of Quinine can be increased when it is combined with Dirithromycin.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Dirithromycin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Dirithromycin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Dirithromycin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Dirithromycin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Dirithromycin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Dirithromycin.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Dirithromycin.
Colchicine The metabolism of Colchicine can be decreased when combined with Dirithromycin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Dirithromycin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Dirithromycin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Dirithromycin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Dirithromycin.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Dirithromycin.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Dirithromycin.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Dirithromycin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Dirithromycin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Dirithromycin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Dirithromycin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Dirithromycin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Dirithromycin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Dirithromycin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Dirithromycin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Dirithromycin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Dirithromycin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Dirithromycin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Dirithromycin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dirithromycin.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Dirithromycin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Dirithromycin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Dirithromycin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Dirithromycin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Dirithromycin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Dirithromycin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Dirithromycin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Dirithromycin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Dirithromycin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Dirithromycin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Dirithromycin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Dirithromycin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Dirithromycin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Dirithromycin.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Dirithromycin.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Dirithromycin.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Dirithromycin.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Dirithromycin.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Dirithromycin.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Dirithromycin.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Dirithromycin.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Dirithromycin.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Dirithromycin.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Dirithromycin.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Dirithromycin.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Dirithromycin.
Acefylline The metabolism of Acefylline can be decreased when combined with Dirithromycin.
Bufylline The metabolism of Bufylline can be decreased when combined with Dirithromycin.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Dirithromycin.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Dirithromycin.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Dirithromycin.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Dirithromycin.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Dirithromycin.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Dirithromycin.
Xanthine The metabolism of Xanthine can be decreased when combined with Dirithromycin.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Dirithromycin.
Guanine The metabolism of Guanine can be decreased when combined with Dirithromycin.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Dirithromycin.
Peldesine The metabolism of Peldesine can be decreased when combined with Dirithromycin.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Dirithromycin.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Dirithromycin.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Dirithromycin.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Dirithromycin.
Uric acid The metabolism of Uric acid can be decreased when combined with Dirithromycin.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Dirithromycin.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Dirithromycin.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Dirithromycin.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Dirithromycin.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Dirithromycin.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Dirithromycin.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Dirithromycin.
Furafylline The metabolism of Furafylline can be decreased when combined with Dirithromycin.
Theobromine The metabolism of Theobromine can be decreased when combined with Dirithromycin.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Dirithromycin.
Caffeine The metabolism of Caffeine can be decreased when combined with Dirithromycin.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Dirithromycin.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Dirithromycin.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Dirithromycin.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Dirithromycin.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Dirithromycin.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Dirithromycin.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Dirithromycin.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Dirithromycin.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Dirithromycin.

Target Protein

23S ribosomal RNA

Referensi & Sumber

Synthesis reference: Counter FT, Ensminger PW, Preston DA, Wu CY, Greene JM, Felty-Duckworth AM, Paschal JW, Kirst HA: Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin. Antimicrob Agents Chemother. 1991 Jun;35(6):1116-26. Pubmed(http://www.ncbi.nlm.nih.gov/pubmed/1929252).
Artikel (PubMed)
  • PMID: 7528132
    Brogden RN, Peters DH: Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1994 Oct;48(4):599-616.
  • PMID: 8893122
    Wintermeyer SM, Abdel-Rahman SM, Nahata MC: Dirithromycin: a new macrolide. Ann Pharmacother. 1996 Oct;30(10):1141-9.
  • PMID: 8478313
    Sides GD, Cerimele BJ, Black HR, Busch U, DeSante KA: Pharmacokinetics of dirithromycin. J Antimicrob Chemother. 1993 Mar;31 Suppl C:65-75.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Dynabac

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul