Peringatan Keamanan

Symptoms of overdose include light-headedness, loss of coordination, tension in the neck, and tiredness.

Naratriptan

DB00952

small molecule approved investigational

Deskripsi

Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.

Struktur Molekul 2D

Berat 335.464
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 5-8 hours
Volume Distribusi * 170 L
Klirens (Clearance) * 6.6 mL/min/kg

Absorpsi

Well absorbed (74% oral biovaility), absorption is rapid with peak plasma concentrations after 2-5 hours. The rate of absorption is slower during a migraine attack.

Metabolisme

Primarily hepatic. In vitro, naratriptan is metabolized by a wide range of cytochrome P450 isoenzymes into a number of inactive metabolites.

Rute Eliminasi

Data eliminasi belum tersedia.

Farmakogenomik

1 Varian
GNB3 (rs5443)

Patients with this genotype have an increased likelihood of responding to naratriptan when treating (condition: cluster headache).

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1085 Data
Valsartan Naratriptan may decrease the antihypertensive activities of Valsartan.
Ramipril Naratriptan may decrease the antihypertensive activities of Ramipril.
Esmolol Naratriptan may decrease the antihypertensive activities of Esmolol.
Betaxolol Naratriptan may decrease the antihypertensive activities of Betaxolol.
Remikiren Naratriptan may decrease the antihypertensive activities of Remikiren.
Torasemide Naratriptan may decrease the antihypertensive activities of Torasemide.
Guanadrel Naratriptan may decrease the antihypertensive activities of Guanadrel.
Metoprolol Naratriptan may decrease the antihypertensive activities of Metoprolol.
Isradipine Naratriptan may decrease the antihypertensive activities of Isradipine.
Olmesartan Naratriptan may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Naratriptan may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Naratriptan may decrease the antihypertensive activities of Nitroprusside.
Atenolol Naratriptan may decrease the antihypertensive activities of Atenolol.
Diltiazem Naratriptan may decrease the antihypertensive activities of Diltiazem.
Minoxidil Naratriptan may decrease the antihypertensive activities of Minoxidil.
Timolol Naratriptan may decrease the antihypertensive activities of Timolol.
Treprostinil Naratriptan may decrease the antihypertensive activities of Treprostinil.
Amlodipine Naratriptan may decrease the antihypertensive activities of Amlodipine.
Nimodipine Naratriptan may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Naratriptan may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Naratriptan may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Naratriptan may decrease the antihypertensive activities of Prazosin.
Fosinopril Naratriptan may decrease the antihypertensive activities of Fosinopril.
Trandolapril Naratriptan may decrease the antihypertensive activities of Trandolapril.
Metolazone Naratriptan may decrease the antihypertensive activities of Metolazone.
Lercanidipine Naratriptan may decrease the antihypertensive activities of Lercanidipine.
Benazepril Naratriptan may decrease the antihypertensive activities of Benazepril.
Bosentan Naratriptan may decrease the antihypertensive activities of Bosentan.
Enalapril Naratriptan may decrease the antihypertensive activities of Enalapril.
Doxazosin Naratriptan may decrease the antihypertensive activities of Doxazosin.
Labetalol Naratriptan may decrease the antihypertensive activities of Labetalol.
Cyclothiazide Naratriptan may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol Naratriptan may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Naratriptan may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Naratriptan may decrease the antihypertensive activities of Mecamylamine.
Losartan Naratriptan may decrease the antihypertensive activities of Losartan.
Moexipril Naratriptan may decrease the antihypertensive activities of Moexipril.
Eplerenone Naratriptan may decrease the antihypertensive activities of Eplerenone.
Lisinopril Naratriptan may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Naratriptan may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Naratriptan may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Naratriptan may decrease the antihypertensive activities of Cryptenamine.
Perindopril Naratriptan may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Naratriptan may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Naratriptan may decrease the antihypertensive activities of Fenoldopam.
Indapamide Naratriptan may decrease the antihypertensive activities of Indapamide.
Tadalafil Naratriptan may decrease the antihypertensive activities of Tadalafil.
Eprosartan Naratriptan may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Naratriptan may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Naratriptan may decrease the antihypertensive activities of Quinapril.
Telmisartan Naratriptan may decrease the antihypertensive activities of Telmisartan.
Methyldopa Naratriptan may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Naratriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Naratriptan may decrease the antihypertensive activities of Trichlormethiazide.
Felodipine Naratriptan may decrease the antihypertensive activities of Felodipine.
Irbesartan Naratriptan may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Naratriptan may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Naratriptan may decrease the antihypertensive activities of Deserpidine.
Pentolinium Naratriptan may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Naratriptan may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Naratriptan may decrease the antihypertensive activities of Diazoxide.
Carvedilol Naratriptan may decrease the antihypertensive activities of Carvedilol.
Bretylium Naratriptan may decrease the antihypertensive activities of Bretylium.
Terazosin Naratriptan may decrease the antihypertensive activities of Terazosin.
Guanethidine Naratriptan may decrease the antihypertensive activities of Guanethidine.
Acebutolol Naratriptan may decrease the antihypertensive activities of Acebutolol.
Captopril Naratriptan may decrease the antihypertensive activities of Captopril.
Nadolol Naratriptan may decrease the antihypertensive activities of Nadolol.
Epoprostenol Naratriptan may decrease the antihypertensive activities of Epoprostenol.
Bepridil Naratriptan may decrease the antihypertensive activities of Bepridil.
Hydralazine Naratriptan may decrease the antihypertensive activities of Hydralazine.
Bevantolol Naratriptan may decrease the antihypertensive activities of Bevantolol.
Practolol Naratriptan may decrease the antihypertensive activities of Practolol.
Polythiazide Naratriptan may decrease the antihypertensive activities of Polythiazide.
Cilazapril Naratriptan may decrease the antihypertensive activities of Cilazapril.
Saprisartan Naratriptan may decrease the antihypertensive activities of Saprisartan.
Spirapril Naratriptan may decrease the antihypertensive activities of Spirapril.
Mibefradil Naratriptan may decrease the antihypertensive activities of Mibefradil.
Dexpropranolol Naratriptan may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Naratriptan may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Naratriptan may decrease the antihypertensive activities of Debrisoquine.
Celiprolol Naratriptan may decrease the antihypertensive activities of Celiprolol.
Nebivolol Naratriptan may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Naratriptan may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Naratriptan may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Naratriptan may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Naratriptan may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Naratriptan may decrease the antihypertensive activities of Pinacidil.
Bupranolol Naratriptan may decrease the antihypertensive activities of Bupranolol.
Temocapril Naratriptan may decrease the antihypertensive activities of Temocapril.
Riociguat Naratriptan may decrease the antihypertensive activities of Riociguat.
Macitentan Naratriptan may decrease the antihypertensive activities of Macitentan.
Indenolol Naratriptan may decrease the antihypertensive activities of Indenolol.
Aliskiren Naratriptan may decrease the antihypertensive activities of Aliskiren.
Trimazosin Naratriptan may decrease the antihypertensive activities of Trimazosin.
Nicorandil Naratriptan may decrease the antihypertensive activities of Nicorandil.
Efonidipine Naratriptan may decrease the antihypertensive activities of Efonidipine.
Lacidipine Naratriptan may decrease the antihypertensive activities of Lacidipine.
Manidipine Naratriptan may decrease the antihypertensive activities of Manidipine.
Niguldipine Naratriptan may decrease the antihypertensive activities of Niguldipine.

Target Protein

5-hydroxytryptamine receptor 1A HTR1A
5-hydroxytryptamine receptor 1D HTR1D
5-hydroxytryptamine receptor 1B HTR1B
5-hydroxytryptamine receptor 1F HTR1F

Referensi & Sumber

Synthesis reference: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Sandip Vasant Chikhalikar, Maruti Ghagare, "Process for the synthesis of naratriptan." U.S. Patent US20120220778, issued August 30, 2012.
Artikel (PubMed)
  • PMID: 12463278
    Massiou H: Naratriptan. Curr Med Res Opin. 2001;17 Suppl 1:s51-3.
  • PMID: 16389295
    Lambert GA: Preclinical neuropharmacology of naratriptan. CNS Drug Rev. 2005 Autumn;11(3):289-316.
  • PMID: 15320857
    Villalon CM, Centurion D, Valdivia LF, de Vries P, Saxena PR: Migraine: pathophysiology, pharmacology, treatment and future trends. Curr Vasc Pharmacol. 2003 Mar;1(1):71-84.

Contoh Produk & Brand

Produk: 29 • International brands: 1
Produk
  • Amerge
    Tablet, film coated • 1 mg/1 • Oral • US • Approved
  • Amerge
    Tablet, film coated • 2.5 mg/1 • Oral • US • Approved
  • Amerge
    Tablet • 1 mg • Oral • Canada • Approved
  • Amerge
    Tablet • 2.5 mg • Oral • Canada • Approved
  • Apo-naratriptan
    Tablet • 1 mg • Oral • Canada • Generic • Approved
  • Apo-naratriptan
    Tablet • 2.5 mg • Oral • Canada • Generic • Approved
  • Naratriptan
    Tablet, film coated • 1 mg/1 • Oral • US • Generic • Approved
  • Naratriptan
    Tablet, film coated • 2.5 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 29 produk.
International Brands
  • Naramig

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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