Peringatan Keamanan

Symptoms of overdose include rash, fever, chills, and peeling skin.

Mezlocillin

DB00948

small molecule approved investigational

Deskripsi

Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.

Struktur Molekul 2D

Berat 539.582
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.3 to 4.4 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Unlike many other penicillins, mezlocillin is either extensively metabolized or is subject to biliary excretion, as only about 50% of the dose was accounted for in normal urine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

190 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Mezlocillin.
Probenecid The excretion of Mezlocillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Mezlocillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Mezlocillin.
Dicoumarol Mezlocillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Mezlocillin may increase the anticoagulant activities of Phenindione.
Warfarin Mezlocillin may increase the anticoagulant activities of Warfarin.
Phenprocoumon Mezlocillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Mezlocillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Mezlocillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Mezlocillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Mezlocillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Mezlocillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Mezlocillin may increase the anticoagulant activities of Fluindione.
Clorindione Mezlocillin may increase the anticoagulant activities of Clorindione.
Diphenadione Mezlocillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Mezlocillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Mezlocillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Mezlocillin.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Mezlocillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Mezlocillin.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Mezlocillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Mezlocillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Mezlocillin.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Mezlocillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Mezlocillin.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Mezlocillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Mezlocillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Mezlocillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Mezlocillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Mezlocillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Mezlocillin.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Mezlocillin.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Mezlocillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Mezlocillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Mezlocillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Mezlocillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Mezlocillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Mezlocillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Mezlocillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Mezlocillin.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Mezlocillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Mezlocillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Mezlocillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Mezlocillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Mezlocillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Mezlocillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Mezlocillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Mezlocillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Mezlocillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Mezlocillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Mezlocillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Mezlocillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Mezlocillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Mezlocillin.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Mezlocillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Mezlocillin.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Mezlocillin.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Mezlocillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Mezlocillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Mezlocillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Mezlocillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Mezlocillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Mezlocillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Mezlocillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Mezlocillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Mezlocillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Mezlocillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Mezlocillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Mezlocillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Mezlocillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Mezlocillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Mezlocillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Mezlocillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Mezlocillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Mezlocillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Mezlocillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Mezlocillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Mezlocillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Mezlocillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Mezlocillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Mezlocillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Mezlocillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Mezlocillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Mezlocillin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Mezlocillin.

Target Protein

Penicillin-binding protein 1A pbpA
Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 2 mrdA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9527154
    Kristof RA, Clusmann H, Koehler W, Fink KB, Schramm J: Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange. J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):379-81.
  • PMID: 9096584
    McCormick PA, Greenslade L, Kibbler CC, Chin JK, Burroughs AK, McIntyre N: A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. Hepatology. 1997 Apr;25(4):833-6.
  • PMID: 9403281
    Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B: Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure. Eur J Clin Pharmacol. 1997;53(2):111-5.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Mezlin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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