Peringatan Keamanan

After a massive overdose, CNS stimulation may be manifested by irrational behavior, marked agitation and generalized seizures. Following this phase, renal toxicity (falling urine output, rising creatinine, abnormal urinary cellular elements) may be noted with possible oliguria or anuria and azotemia. A 24 year-old male was anuric for approximately one week after ingesting an overdose of 6 to 7 grams of meclofenamate sodium. Spontaneous diuresis and recovery subsequently occurred.

Meclofenamic acid

DB00939

small molecule approved vet_approved

Deskripsi

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Struktur Molekul 2D

Berat 296.149
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) In a study in 10 healthy subjects following a single oral dose the apparent elimination half-life ranged from 0.8 to 5.3 hours. Metabolite I (3-hydroxymethyl metabolite of meclofenamic acid) has a mean half-life of approximately 15 hours.
Volume Distribusi * 9.1 to 43.2 L
Klirens (Clearance) * Oral cl=206 mL/min

Absorpsi

Rapidly absorbed in man following single and multiple oral doses with peak plasma concentrations occurring in 0.5 to 2 hours. The concomitant administration of antacids (aluminum and magnesium hydroxides) does not interfere with absorption of meclofenamic acid. Unlike most NSAIDs, which when administered with food have a decrease in rate but not in extent of absorption, meclofenamic acid is decreased in both. It has been reported that following the administration of meclofenamic acid capsules one-half hour after a meal, the average extent of bioavailability decreased by 26%, the average peak concentration (Cmax) decreased fourfold and the time to Cmax was delayed by 3 hours.

Metabolisme

Hepatic. Meclofenamic acid is extensively metabolized to an active metabolite (Metabolite I; 3-hydroxymethyl metabolite of meclofenamic acid) and at least six other less well characterized minor metabolites. Only Metabolite I has been shown in vitro to inhibit cyclooxygenase activity with approximately one fifth the activity of meclofenamic acid.

Rute Eliminasi

Other metabolites, whose excretion rates are unknown, account for the remaining 35% to 62% of the dose excreted in the urine. The remainder of the administered dose (approximately 30%) is eliminated in the feces (apparently through biliary excretion). Trace amounts of meclofenamate sodium are excreted in human breast milk.

Interaksi Makanan

2 Data
  • 1. Avoid excessive or chronic alcohol consumption. Ingesting alcohol may increase the risk of developing a gastrointestinal bleed.
  • 2. Take with or without food. Taking meclofenamic acid with food reduces the rate and extent of its absorption; however it also reduces gastrointestinal upset caused by meclofenamic acid.

Interaksi Obat

1460 Data
Amlodipine Meclofenamic acid may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Meclofenamic acid.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Meclofenamic acid.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Meclofenamic acid.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Meclofenamic acid.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Meclofenamic acid.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Meclofenamic acid.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Meclofenamic acid.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Meclofenamic acid.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Meclofenamic acid.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Meclofenamic acid.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Meclofenamic acid.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Meclofenamic acid.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Meclofenamic acid.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Meclofenamic acid.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Meclofenamic acid.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Meclofenamic acid.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Meclofenamic acid.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Meclofenamic acid.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Meclofenamic acid.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Meclofenamic acid.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Meclofenamic acid.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Meclofenamic acid.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Meclofenamic acid.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Meclofenamic acid.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Meclofenamic acid.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Meclofenamic acid.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Meclofenamic acid.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Meclofenamic acid.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Meclofenamic acid.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Meclofenamic acid.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Meclofenamic acid.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Meclofenamic acid.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Meclofenamic acid.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Meclofenamic acid.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Meclofenamic acid.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Meclofenamic acid.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Meclofenamic acid.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Meclofenamic acid.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Meclofenamic acid.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Meclofenamic acid.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Meclofenamic acid.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Meclofenamic acid.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Meclofenamic acid.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Meclofenamic acid.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Meclofenamic acid.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Meclofenamic acid.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Meclofenamic acid.
Naratriptan The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Naratriptan.
Formoterol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Formoterol.
Frovatriptan The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Frovatriptan.
Methoxyflurane The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Methoxyflurane.
Selegiline The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Selegiline.
Ergoloid mesylate The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Dutasteride.
Halothane The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Halothane.
Moclobemide The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Moclobemide.
Pergolide The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Meclofenamic acid is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Meclofenamic acid is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Meclofenamic acid is combined with Iloperidone.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2
Polyunsaturated fatty acid 5-lipoxygenase ALOX5
Potassium voltage-gated channel subfamily KQT member 2 KCNQ2
Potassium voltage-gated channel subfamily KQT member 3 KCNQ3

Referensi & Sumber

Synthesis reference: U.S. Patent 3,313,848.

Contoh Produk & Brand

Produk: 3 • International brands: 3
Produk
  • Meclofenamate Sodium
    Capsule • 50 mg/1 • Oral • US • Generic • Approved
  • Meclofenamate Sodium
    Capsule • 50 mg/1 • Oral • US • Generic • Approved
  • Meclofenamate Sodium
    Capsule • 100 mg/1 • Oral • US • Generic • Approved
International Brands
  • Ethos — Yung Shin
  • Eucome — U-Liang
  • Meclomen — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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