Peringatan Keamanan

The reported oral LD50 for mice is 600 mg/kg, for rats is 250 mg/kg and for dogs is 225 mg/kg. Manifestation of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states.

Diethylpropion

DB00937

small molecule approved illicit

Deskripsi

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Struktur Molekul 2D

Berat 205.2961
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Using a phosphorescence assay that is specific for basic compounds containing benzoyl group, the plasma half-life of the aminoketone metabolites is estimated to be between 4 to 6 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Diethylpropion is rapidly absorbed from the GI tract after oral administration.

Metabolisme

Extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction. Many of these metabolites are biologically active and may participate in the therapeutic action of diethylpropion.

Rute Eliminasi

Diethylpropion is rapidly absorbed from the GI tract after oral administration and is extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction. Diethylpropion and/or its active metabolites are believed to cross the blood-brain barrier and the placenta. Diethylpropion and its metabolites are excreted mainly by the kidney.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1304 Data
Valsartan Diethylpropion may decrease the antihypertensive activities of Valsartan.
Ramipril Diethylpropion may decrease the antihypertensive activities of Ramipril.
Remikiren Diethylpropion may decrease the antihypertensive activities of Remikiren.
Torasemide Diethylpropion may decrease the antihypertensive activities of Torasemide.
Isradipine Diethylpropion may decrease the antihypertensive activities of Isradipine.
Olmesartan Diethylpropion may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Diethylpropion may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Diethylpropion may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Diethylpropion may decrease the antihypertensive activities of Diltiazem.
Minoxidil Diethylpropion may decrease the antihypertensive activities of Minoxidil.
Treprostinil Diethylpropion may decrease the antihypertensive activities of Treprostinil.
Amlodipine Diethylpropion may decrease the antihypertensive activities of Amlodipine.
Nimodipine Diethylpropion may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Diethylpropion may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Diethylpropion may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Diethylpropion may decrease the antihypertensive activities of Fosinopril.
Trandolapril Diethylpropion may decrease the antihypertensive activities of Trandolapril.
Metolazone Diethylpropion may decrease the antihypertensive activities of Metolazone.
Lercanidipine Diethylpropion may decrease the antihypertensive activities of Lercanidipine.
Benazepril Diethylpropion may decrease the antihypertensive activities of Benazepril.
Bosentan Diethylpropion may decrease the antihypertensive activities of Bosentan.
Enalapril Diethylpropion may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Diethylpropion may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Diethylpropion may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Diethylpropion may decrease the antihypertensive activities of Mecamylamine.
Losartan Diethylpropion may decrease the antihypertensive activities of Losartan.
Moexipril Diethylpropion may decrease the antihypertensive activities of Moexipril.
Eplerenone Diethylpropion may decrease the antihypertensive activities of Eplerenone.
Lisinopril Diethylpropion may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Diethylpropion may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Diethylpropion may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Diethylpropion may decrease the antihypertensive activities of Cryptenamine.
Perindopril Diethylpropion may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Diethylpropion may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Diethylpropion may decrease the antihypertensive activities of Fenoldopam.
Indapamide Diethylpropion may decrease the antihypertensive activities of Indapamide.
Tadalafil Diethylpropion may decrease the antihypertensive activities of Tadalafil.
Eprosartan Diethylpropion may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Diethylpropion may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Diethylpropion may decrease the antihypertensive activities of Quinapril.
Telmisartan Diethylpropion may decrease the antihypertensive activities of Telmisartan.
Methyldopa Diethylpropion may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Diethylpropion may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Diethylpropion may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Diethylpropion may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Diethylpropion may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Diethylpropion may decrease the antihypertensive activities of Deserpidine.
Pentolinium Diethylpropion may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Diethylpropion may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Diethylpropion may decrease the antihypertensive activities of Diazoxide.
Captopril Diethylpropion may decrease the antihypertensive activities of Captopril.
Epoprostenol Diethylpropion may decrease the antihypertensive activities of Epoprostenol.
Bepridil Diethylpropion may decrease the antihypertensive activities of Bepridil.
Hydralazine Diethylpropion may decrease the antihypertensive activities of Hydralazine.
Polythiazide Diethylpropion may decrease the antihypertensive activities of Polythiazide.
Cilazapril Diethylpropion may decrease the antihypertensive activities of Cilazapril.
Saprisartan Diethylpropion may decrease the antihypertensive activities of Saprisartan.
Spirapril Diethylpropion may decrease the antihypertensive activities of Spirapril.
Mibefradil Diethylpropion may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Diethylpropion may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Diethylpropion may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Diethylpropion may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Diethylpropion may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Diethylpropion may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Diethylpropion may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Diethylpropion may decrease the antihypertensive activities of Pinacidil.
Temocapril Diethylpropion may decrease the antihypertensive activities of Temocapril.
Riociguat Diethylpropion may decrease the antihypertensive activities of Riociguat.
Macitentan Diethylpropion may decrease the antihypertensive activities of Macitentan.
Aliskiren Diethylpropion may decrease the antihypertensive activities of Aliskiren.
Nicorandil Diethylpropion may decrease the antihypertensive activities of Nicorandil.
Efonidipine Diethylpropion may decrease the antihypertensive activities of Efonidipine.
Lacidipine Diethylpropion may decrease the antihypertensive activities of Lacidipine.
Manidipine Diethylpropion may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Diethylpropion may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Diethylpropion may decrease the antihypertensive activities of Enalaprilat.
Selexipag Diethylpropion may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Diethylpropion may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Diethylpropion may decrease the antihypertensive activities of Imidapril.
BQ-123 Diethylpropion may decrease the antihypertensive activities of BQ-123.
Cicletanine Diethylpropion may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Diethylpropion may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Diethylpropion may decrease the antihypertensive activities of Zofenopril.
Guanoxan Diethylpropion may decrease the antihypertensive activities of Guanoxan.
Delapril Diethylpropion may decrease the antihypertensive activities of Delapril.
Vincamine Diethylpropion may decrease the antihypertensive activities of Vincamine.
Linsidomine Diethylpropion may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Diethylpropion may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Diethylpropion may decrease the antihypertensive activities of Tolonidine.
Endralazine Diethylpropion may decrease the antihypertensive activities of Endralazine.
Cadralazine Diethylpropion may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Diethylpropion may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Diethylpropion may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Diethylpropion may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Diethylpropion may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Diethylpropion may decrease the antihypertensive activities of Guanoclor.
Muzolimine Diethylpropion may decrease the antihypertensive activities of Muzolimine.
Xipamide Diethylpropion may decrease the antihypertensive activities of Xipamide.
Candesartan Diethylpropion may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Diethylpropion may decrease the antihypertensive activities of Dexniguldipine.

Target Protein

Sodium-dependent noradrenaline transporter SLC6A2
Sodium-dependent serotonin transporter SLC6A4
Sodium-dependent dopamine transporter SLC6A3

Referensi & Sumber

Synthesis reference: Schutte, J.; U.S. Patent 3,001,910; September 26, 1961; assigned to Firma Ternmler-Werke (W. Germany).
Artikel (PubMed)
  • PMID: 18353447
    Adan RA, Vanderschuren LJ, la Fleur SE: Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci. 2008 Apr;29(4):208-17. doi: 10.1016/j.tips.2008.01.008. Epub 2008 Mar 18.
  • PMID: 19897080
    Arias HR, Santamaria A, Ali SF: Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion. Int Rev Neurobiol. 2009;88:223-55. doi: 10.1016/S0074-7742(09)88009-4.

Contoh Produk & Brand

Produk: 57 • International brands: 10
Produk
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Generic • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Generic • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Approved
  • Diethylpropion HCl Controlled-Release
    Tablet • 75 mg/1 • Oral • US • Approved
Menampilkan 8 dari 57 produk.
International Brands
  • Anorex
  • Dobesin
  • Frekentine
  • Linea
  • Moderatan
  • Neobes — Medix
  • Nobesine
  • Prefamone
  • Regenon — Temmler
  • Tylinal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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